A Phase II Study Assessing the Effects of Aerobic Exercise During and After Breast Cancer Chemotherapy


Full Title

Optimal Timing Trial: Randomized Trial of Supervised Aerobic Training During or After Chemotherapy for Operable Breast Cancer


Chemotherapy for breast cancer can cause fatigue and other side effects. There is some evidence that exercise may help women receiving chemotherapy to feel less tired and more energetic. The goal of this study is to see how supervised aerobic exercise during and after chemotherapy for operable breast cancer affects a woman’s exercise capacity and other measures of heart and lung function.

Patients will be randomly assigned to one of four groups: exercise during chemotherapy, exercise after chemotherapy, exercise during and after chemotherapy, and a control group who will not undergo supervised exercise during or after chemotherapy. The exercise will include supervised aerobic exercise on a treadmill at one of Memorial Sloan Kettering’s Manhattan locations. Women will undergo assessment of their exercise capacity, heart and lung function, and other measures before, during, and after the study, and the findings from these different points will be compared.


To be eligible for this study, patients must meet several criteria, including but not limited to the following:

  • Patients must be women who had surgery for HER2-negative breast cancer and who will be receiving chemotherapy with doxorubicin, cyclophosphamide, and paclitaxel.
  • This study is for sedentary women.
  • Participants must be able to come to Manhattan for their exercise sessions.
  • This study is for women age 21 and older.

For more information about this study and to inquire about eligibility, contact Dr. Lee Jones at 646-888-8102.






Scott, Jessica, PhD