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A Study of EBV Cytotoxic T Lymphocytes to Treat EBV Lymphoma and Lymphoproliferative Disorders

Full Title

Multicenter Expanded Access Protocol of ATA129 for Subjects with Epstein-Barr Virus-Associated Viremia or Malignancies for Whom There are No Appropriate Alternative Therapies (Atara EBV-CTL-201)


This study is evaluating a treatment for lymphomas and lymphoproliferative disorders caused by the Epstein-Barr Virus (EBV) in patients with defined defects in their immune systems who have no other treatment options. The treatment consists of white blood cells called cytotoxic T lymphocytes (CTLs) that are donated by a healthy person, grown in a laboratory to educate them to recognize and destroy EBV-infected cells, and then given by intravenous infusion (through a vein) to a patient whose EBV disorder or lymphoma matches or partially matches the EBV-CTLs.


To be eligible for this study, patients must meet several criteria, including but not limited to the following:

  • Patients must have an EBV lymphoma or lymphoproliferative disorder, a defect in their immune system, and no other treatment options.
  • Patients must have matched or partially matched EBV-CTLs available as treatment.
  • This study is open to children and adults.

For more information about this study and to inquire about eligibility, please contact Dr. Susan Prockop at 212-639-6715.





Disease Status

Newly Diagnosed & Relapsed/Refractory