A Study of Memory, Thinking, and Brain Imaging in Adults with Histiocytosis


Full Title

A Clinical, Structural, and Functional Neuroimaging Study of Cognition in Adults with Erdheim-Chester Disease, Langerhans Cell Histiocytosis, Rosai-Dorfman Disease, and other Histiocytoses


Histiocytosis is a general name for a group of diseases that involve an abnormal increase in the number of immune cells called histiocytes. Examples include Erdheim-Chester disease, Langerhans cell histiocytosis, Rosai-Dorfman disease, and histiocytic sarcoma. In some patients, histiocytosis causes tumors to grow in or near the brain, causing trouble with movement, mood, and/or thinking. Some patients experience these symptoms without tumors in or near the brain, for reasons that are not understood.

In this study, researchers will perform MRI testing and assessments of thinking and memory in people with histiocytosis who do not have tumors in or near the brain or other disorders that may impair these functions. The findings will be compared with those from healthy people without histiocytosis. The goal is to gain a better understanding of mood, memory, and thinking problems in people with histiocytosis.


This study is for English-speaking adults (age 18 and older) with histiocytosis who do not have tumors in or near the brain nor other potential causes of brain dysfunction (such as stroke or certain medications).

For more information about this study, please contact Dr. Eli Diamond at 212-610-0243.



Disease Status

Newly Diagnosed & Relapsed/Refractory