Full TitleA Phase 2 Study of Abemaciclib in Patients with Recurrent Primary Brain Tumors
The purpose of this study is to assess the safety and effectiveness of the drug abemaciclib in patients with brain tumors that have come back despite prior radiation therapy and/or chemotherapy. The study will include patients with glioma, meningioma, ependymoma, primary central nervous system lymphoma, and other brain tumor types.
Abemaciclib is designed to inhibit cancer growth by blocking cyclin-dependent kinases (CDK), enzymes which cancer cells need to grow and divide. It is approved for treating metastatic breast cancer; its use in this study is investigational. It is taken orally (by mouth).
To be eligible for this study, patients must meet several criteria, including but not limited to the following:
- Patients must have a brain tumor that has come back or continued to grow despite prior treatment.
- Patients must recover from the serious side effects of prior therapies before entering the study.
- This study is for patients age 18 and older.