A Phase III Study Comparing Observation Versus Radiation Therapy for Newly Diagnosed Grade II Meningiomas Completely Removed through Surgery


Full Title

Phase III Trial of Observation Versus Irradiation for A gross Totally Resected Grade II Meningioma (NRG BN003)(CIRB)


People who have had a grade II meningioma (a type of brain tumor) completely removed with surgery may be observed without treatment; treated with radiation after surgery; or treated with radiation therapy only if the tumor comes back. The purpose of this study is to compare observation with radiation therapy to determine the extent of clinical benefit achieved with radiation following surgery.


To be eligible for this study, patients must meet several criteria, including but not limited to the following:

  • Patients must have had a grade II meningioma that was completely removed through surgery within 6 months of entering the study.
  • Patients may not have received prior radiation therapy to the head.
  • Patients must be physically well enough that they are fully ambulatory, capable of all self care, and are capable of all but physically strenuous activities. As an example, patients must be well enough that they would be able to carry out office work or light housework.
  • This study is for patients age 18 and older.

For more information about this study and to inquire about eligibility, please contact Dr. T. Jonathan Yang at 212-639-8157.