A Phase IA/IB Study of TTI-622 Immunotherapy in Patients with Advanced Persistent or Recurrent Blood Cancers


Full Title

A Phase 1a/1b Dose-Escalation and Expansion Trial of TTI-622 in Patients with Advanced Hematologic Malignancies, Including Lymphoma, Leukemia, and Multiple Myeloma


This study has two parts. The purpose of the phase IA part of the study is to find the highest dose of the investigational drug TTI-622 that can be given safely in patients with non-Hodgkin lymphoma or Hodgkin lymphoma that continues to grow or came back after prior treatment.

In the phase IB part, researchers will assess the safety of combining TTI-622 with standard treatments. Patients with non-Hodgkin lymphoma will receive TTI-622 with rituximab; those with Hodgkin lymphoma will receive TTI-622 with nivolumab; patients with acute myeloid leukemia will receive TTI-622 either with azacitidine or with azacitidine/venetoclax; and patients with multiple myeloma will receive TTI-622 with carfilzomib.

TTI-622 is a fusion of two proteins. One binds with other proteins found on the surface of certain immune cells. The other protein interacts with a protein on cancer cells called CD47, which cancer cells use to hide from the immune system. Blocking CD47 with TTI-622 may help the immune system find and destroy cancer cells. TTI-622 is given intravenously (by vein).

Who Can Join

To be eligible for this study, patients must meet several criteria, including but not limited to the following:

  • Patients must have non-Hodgkin lymphoma, Hodgkin lymphoma, acute myeloid leukemia, or multiple myeloma that continues to grow or came back after prior treatment.
  • Patients should recover from the serious side effects of previous therapies before entering the study.
  • Patients must be able to walk and do routine activities for more than half of their normal waking hours.
  • This study is for patients age 18 and older.



For more information and to ask about eligibility for this study, please contact the office of Dr. Alexander Lesokhin at 646-608-3717.




Phase I (phase 1)

Disease Status

Relapsed or Refractory


ClinicalTrials.gov ID