A Phase I Study of Selinexor to Treat Persistent and Recurrent Brain Tumors and Other Solid Tumors in Children, Teens, and Young Adults

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Full Title

A Phase 1 Study of Selinexor (KPT-330, IND #125052), A Selective XPO1 Inhibitor, in Recurrent and Refractory Pediatric Solid Tumors, Including CNS Tumors (ADVL1414) (CIRB)

Purpose

Selinexor is a drug used to treat multiple myeloma and a type of lymphoma in adults. Researchers want to know if selinexor is safe to use in children, teens, and young adults with cancer. In this study, they want to find the best dose of selinexor to use safely in young patients with brain and spinal cord tumors and other solid tumors that continue to grow or have come back despite prior treatment. Selinexor is taken orally (by mouth).

Eligibility

To be eligible for this study, patients must meet several criteria, including but not limited to the following:

  • This study is for patients ages 1-21 years.
  • Patients must have a brain tumor (such as high-grade glioma), spinal cord tumor, or other solid tumor that has continued to grow or came back after previous treatment.
  • Patients must recover from the serious side effects of prior therapies before receiving selinexor.
  • Patients must be able to walk and do routine activities for more than half of their normal waking hours.

For more information about this study and to inquire about eligibility, please contact 1-833-MSK-KIDS.

Protocol

20-108

Phase

I

Disease Status

Relapsed or Refractory

Investigator

Co-Investigators