A Study Assessing a Shortened Radiation Therapy Schedule in People Who Had a Mastectomy for Early Breast Cancer

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Full Title

Fractionation Accelerated beyond Standard Therapy for Post-Mastectomy Radiotherapy in Patients with Reconstructions (FAST-R trial): A Prospective Non-inferiority Trial of Ultra-compressed Treatment

Purpose

Radiation therapy is commonly given after mastectomy for early-stage breast cancer to reduce the chance of the cancer coming back. The standard schedule for radiation therapy is 16 to 25 days. A shortened schedule could be more convenient for patients. Studies have shown that a compressed radiation therapy schedule can be safe and effective in patients who had a lumpectomy; however, there is limited information about how well this schedule works after mastectomy.

Researchers in this study are assessing the safety and effectiveness of a compressed 5-day radiation therapy schedule to see how it compares with the standard 16-25 day schedule in patients with early-stage breast cancer who had a mastectomy. Everyone in this study will have radiation therapy for just five days.

Eligibility

To be eligible for this study, patients must meet several criteria, including but not limited to the following:

  • Patients must have had mastectomy for stage II-III breast cancer and have a chest wall reconstruction in progress or completed.
  • Patients may not have metastatic breast cancer.
  • Prior radiation therapy to the chest is not permitted.
  • Patients must be physically well enough that they are fully ambulatory, capable of all self-care, and capable of all but physically strenuous activities. As an example, patients must be well enough that they would be able to carry out office work or light housework.
  • This study is for patients age 30 and older.

For more information about this study and to inquire about eligibility, please contact the office of Dr. Atif Khan at 848-225-6334.

Protocol

20-513

Phase

0

Investigator