A Study Assessing a Shortened Radiation Therapy Schedule in People Who Had a Mastectomy for Early Breast Cancer


Full Title

Fractionation Accelerated beyond Standard Therapy for Post-Mastectomy Radiotherapy in Patients with Reconstructions (FAST-R trial): A Prospective Non-inferiority Trial of Ultra-compressed Treatment


Radiation therapy is commonly given after mastectomy for early-stage breast cancer to reduce the chance of the cancer coming back. The standard schedule for radiation therapy is 16 to 25 days. A shortened schedule could be more convenient for patients. Studies have shown that a compressed radiation therapy schedule can be safe and effective in patients who had a lumpectomy; however, there is limited information about how well this schedule works after mastectomy.

Researchers in this study are assessing the safety and effectiveness of a compressed 5-day radiation therapy schedule to see how it compares with the standard 16-25 day schedule in patients with early-stage breast cancer who had a mastectomy. Everyone in this study will have radiation therapy for just five days.


To be eligible for this study, patients must meet several criteria, including but not limited to the following:

  • Patients must have had mastectomy for stage II-III breast cancer and have a chest wall reconstruction in progress or completed.
  • Patients may not have metastatic breast cancer.
  • Prior radiation therapy to the chest is not permitted.
  • Patients must be physically well enough that they are fully ambulatory, capable of all self-care, and capable of all but physically strenuous activities. As an example, patients must be well enough that they would be able to carry out office work or light housework.
  • This study is for patients age 30 and older.

For more information about this study and to inquire about eligibility, please contact the office of Dr. Atif Khan at 848-225-6334.