A Phase II Study of Radiation Therapy Guided by Special Imaging Techniques in People with Basal Cell Skin Cancer


Full Title

A Phase II Trial of Reflectance ConfocaL Microscopy And Optical Coherence Tomography Guided RadIation TherapY: CLARITY


The most effective treatment for basal cell carcinoma of the skin is surgery, but it is not a treatment choice for all patients. The most effective non-surgical treatment is radiation therapy, but it can be hard to see all of the cancer cells that need to be treated and to determine which cells are cancerous and which are healthy.

Reflectance confocal microscopy (RCM) and optimal coherence tomography (OCT) are two imaging tools routinely used to see if skin cancer is present. RCM uses a laser to see which cells are cancerous and identify the outer edges of a tumor. OCT uses near-infrared light (invisible and deeply penetrating light) to see how deep cancer cells go.

Researchers think that combining these two imaging tools into one device (the RCM/OCT device) to guide radiation therapy could help basal cell cancer treatment. They are doing this study to find out if radiation therapy guided by the RCM/OCT device is an effective treatment for this cancer.

Who Can Join

To be eligible for this study, patients must meet several requirements, including:

  • Participants must have stage I or II basal cell carcinoma and be candidates for radiation therapy.
  • This study is for people age 18 and older.

For more information and to ask about eligibility for this study, please contact the office of Dr. Christopher Barker at 212-639-8168.




Phase II (phase 2)


ClinicalTrials.gov ID