Full TitleA Phase Ib Study Of The Combination Of CD47 Blockade With SIRP-Alpha FC Fusion Proteins (TTI-622) And Daratumumab Hyaluronidase-fihj For Patients With Relapsed or Refractory Multiple Myeloma
The purpose of this study is to find the highest doses of the investigational drugs TTI-621 and TTI-622 that can be given in combination with daratumumab hyaluronidase-fihj in people with multiple myeloma that has come back or continued to grow despite treatment. TTI-621 and TTI-622 each work by helping the immune system find and kill cancer cells.
Patients in this study will receive either TTI-621 or TTI-622 (but not both) in combination with daratumumab hyaluronidase-fihj. TTI-621 and TTI-622 are given intravenously (by vein). Daratumumab hyaluronidase-fihj is given as an injection subcutaneously (under the skin).
To be eligible for this study, patients must meet several requirements, including:
- Participants must have multiple myeloma that persists despite at least three prior regimens of therapy.
- Patients should recover from the serious side effects of previous treatments before receiving the study treatment.
- Patients must be able to walk and do routine activities for more than half of their normal waking hours.
- This study is for people age 18 and older.
For more information and to ask about eligibility for this study, please contact the office of Dr. Alexander Lesokhin at 646-608-3717.