Hugo R. Castro-Malaspina, MD

Hugo R. Castro-Malaspina, MD

Hematologic Oncologist

Clinical Expertise

Myelodysplastic Syndromes; Leukemias; Myelofibrosis; Bone Marrow Failure; Bone Marrow Transplantation; Aplastic Anemia

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About Me


MD, Universidad Peruana Cayetano Heredia


Internal Medicine - Hospital Saint Louis


Hematology/Oncology - Hospital Saint Louis

Board Certifications

Internal Medicine (France); Hematology/Oncology (France); Pediatric Hematology (France)

I am a board-certified hematologist and oncologist, and I am a member of a multidisciplinary team that cares for patients who are undergoing bone marrow transplantation. My particular expertise is using transplantation to treat patients with myelodysplastic syndromes and with acute myelogenous leukemia (AML) that has evolved from myelodysplastic syndromes. I am also interested in bone marrow failure syndromes including aplastic anemia and paroxysmal nocturnal hemoglobinuria. In an effort to improve the outcomes of patients undergoing transplantation, I design and monitor clinical trials of newer transplantation approaches.

Physicians in Memorial Sloan Kettering’s allogeneic transplant program use stem cells or bone marrow derived from a donor other than the patient for the transplant. We often use T cell depletion — a technique to separate out specific immune cells called T lymphocytes from the stem cell product — to reduce one of the major complications of allogeneic transplants, graft-vs-host disease (GvHD). My clinical research has proven the effectiveness of T cell depleted allogeneic transplants in treating myelodysplastic syndrome; and has established which patients derive the most leukemia-fighting benefit from allogeneic transplants. I am leading a follow-up clinical trial for this disease, using lower doses of chemotherapy before transplantation and new drugs to reduce the risk of infection afterward.

I am also interested in developing new therapies to treat patients with indolent or low-grade lymphomas. These forms of lymphoma are less sensitive than higher-grade forms of the disease to chemotherapy and/or radiation therapy, but are sensitive to the anti-lymphoma effects of an allogeneic bone marrow transplant. In collaboration with the Lymphoma Service, I am exploring potentially curative approaches for patients with low-grade lymphomas, including nonmyeloablative conditioning followed by an unmodified transplant with drug therapy to prevent GvHD.

I am Chairman of Memorial Sloan Kettering’s Bone Marrow Transplant Quality Assurance Committee, which oversees transplant services for adult and pediatric patients, and those with hematologic malignancies and germ cell tumors and ensures that these patients receive quality clinical care. I am also a member of the Center’s Institutional Review Board and Privacy Board. Membership on the IRB has provided me with a broad perspective over clinical research across the entire Center.

I am committed to teaching young physicians by example, thereby enhancing their interest and potential choice to train in this field.

I am also a reviewer for several journals including Blood, BMT, BBMT, American Journal of Hematology, Hematology, Leukemia, and JAMA.


Doctors at Memorial Sloan Kettering work as teams, with specialists from all different areas. This allows us to consider all your needs together, and to give you the best possible care.

Clinical Trials

Smiling doctors in the lab

Find a Clinical Trial for You

Memorial Sloan Kettering's doctors and scientists are constantly developing new treatments for cancer. MSK is typically running hundreds of clinical trials at a given time.

You may be able to participate in a clinical trial even if you are new to MSK. Search our online directory to find trial information and see more about who can participate.

Research and Publications

Publications on PubMed

Visit PubMed for a full listing of Dr. Castro-Malaspina’s journal articles. Pubmed is an online index of research papers and other articles from the US National Library of Medicine and the National Institutes of Health.