I have devoted my career to caring for patients with head and neck tumors. My clinical interests include precancerous lesions, cancer of the mouth, throat, neck, and larynx, melanoma and other skin cancers, salivary tumors, thyroid cancer, and cancers of the sinuses and skull base. My goal is to provide patients with advanced surgical care for head and neck cancer with an emphasis on quality-of-life issues, such as retaining a patient’s ability to speak and swallow and maintaining normal appearance. Many surgical procedures for head and neck cancer that have been developed at Memorial Sloan Kettering help to preserve organ function and facial appearance to a far greater degree than was once possible. I also work closely with plastic surgeons, radiation therapists, chemotherapists, nurses, and speech therapists to create individualized treatment plans that keep the cure of cancer as the main goal.
My research has lead to an improved understanding of the genetic steps involved in cancer formation. My collaborators and I are studying the process by which tobacco use leads to cancer, in an effort to find ways to stop or reverse this process. We have also identified new targets for the prevention and treatment of cancer. I am currently leading a clinical trial at Memorial Sloan Kettering that evaluates a COX-2 inhibitor for the treatment of precancerous leukoplakia in the mouth and throat. COX-2 is an enzyme that has been linked to inflammation and tumor formation and growth.
I have written many scientific papers on the causes of head and neck cancer and prevention of this disease. I have also published clinical papers and book chapters, and I speak nationally and internationally on head and neck cancer topics.
I see patients at Memorial Sloan Kettering facilities in both New York City and Basking Ridge, New Jersey. Head and neck surgery patients who reside in New Jersey or Pennsylvania may choose to have their evaluations and follow-up care in Basking Ridge. (Currently, all surgeries are performed at the main hospital in Manhattan.) For some patients, the ability to receive follow-up care in a facility closer to home is very convenient.
- Clinical Expertise: Head and Neck Surgery/Oncology; Oral and Throat Cancer; Thyroid Cancer; Salivary Cancer; Melanoma and Skin Cancer
- Languages Spoken: English
- Education: MD, University of Arizona College of Medicine
- Residencies: The Johns Hopkins Hospital
- Fellowships: Memorial Sloan Kettering Cancer Center; University of Arizona, Arizona Cancer Center
- Board Certifications: Otolaryngology
“Inhibition of cyclooxygenase-2 expression: An approach to preventing head and neck cancer.” Mestre JR, Chan G, Zhang F, Yang EK, Sacks PG, Boyle JO, Shah JP, Edelstein D, Subbaramaiah K, Dannenberge AJ. In: Cancer Prevention: Novel Nutrient and Pharmaceutical Developments (Annals of the New York Academy of Sciences, vol. 889). Bradlow HL, Fishman J, Osborne MP, eds. New York: New York Academy of Sciences; 1999: 62-71.
“Inhibition of cyclooxygenase-2: An approach to preventing cancer of the upper aerodigestive tract.” Dannenberg AJ, Altorki NK, Boyle JO, Lin DT, Subbaramaiah K. In: Cancer Prevention: Molecular Mechanisms to Clinical Applications (Annals of the New York Academy of Sciences, vol. 889). Osborne MP, ed. New York: New York Academy of Sciences; 2001: 109-115.
“Complications of surgery of the oral cavity.” Boyle JO, Reid V. In: Complications in Head and Neck Surgery. Eisele DW, Smith RV, eds. Philadelphia: WB Saunders; 2009: 257-266.
As home to one of the world’s top cancer research centers, Memorial Sloan Kettering is typically involved in more than 900 clinical trials at a given time. Currently, clinical trials focused on the conditions I treat are enrolling new patients. If you’re interested in joining a clinical trial, click to learn about the trial’s purpose, eligibility criteria, and how to get more information.Learn more