Memorial Sloan Kettering surgeon Jose Guillem

José G. Guillem, MD, MPH, FACS, FASCRS



Director, Hereditary Colorectal Cancer Family Registry

Clinical Expertise

Colorectal and Anal Cancer; Intestinal Carcinoid Tumors; Abdominal Desmoid Tumors; Crohn's Disease; Colitis; Benign Anorectal Diseases; Pseudomyxoma Peritonei; Transanal Endoscopic Microsurgery (TEM); Robotic Surgery

New Patient Appointments

Scheduling a visit is easy. Click below or call us to get started.

Accepted Insurance Providers

Dr. Guillem accepts the following list of insurance providers. Select your insurance provider to see more details.

Contact and Location

Locations map

Find a Convenient Location

Memorial Sloan Kettering has locations throughout New York City, Long Island, New Jersey, and Westchester. These locations offers many services, including screening, chemotherapy, and medical testing.

About Me


MD, Yale University School of Medicine


Surgery - Columbia Presbyterian Medical Center


Colorectal Surgery - Lahey Clinic Medical Center

Board Certifications

Surgery; Colon and Rectal Surgery

I am a colorectal surgeon and I have been part of the Memorial Sloan Kettering team since 1991. I specialize in caring for people with primary and recurrent colon and rectal cancer, early-onset colorectal cancer, and hereditary colorectal cancer. I am also the Director of MSK’s Hereditary Colorectal Cancer Family Registry. My surgical expertise includes the use of minimally invasive techniques, such as transanal endoscopic microsurgery, endoscopy, laparoscopy, and robotic procedures. These techniques allow me to provide my patients with optimal surgical outcomes and shortened recovery times. They can also preserve important aspects of their quality of life, such as anal, bladder, and sexual function.

Since the 1990s, MSK’s Hereditary Colorectal Cancer Family Registry has grown into an important tool for patients, families, and doctors around the world. It provides data that deepen our understanding of early-onset and hereditary colorectal cancer. The result is newer and better treatments, screening recommendations, and surveillance programs. We are then able to identify people who are at a high risk for developing colorectal cancer, and we can monitor them closely. When we can catch any cancer that may develop sooner, the chance of an improved outcome increases.

My research has been funded in part by the National Cancer Institute, the American Cancer Society, the American Society of Colon and Rectal Surgeons Research Foundation (ASCRSRF), and generous patient contributions. I have investigated the causes of colorectal cancer growth and metastases, early-onset and inherited forms of the disease, as well as rectal cancer response to preoperative chemotherapy and radiation therapy.

During the course of my career, I have co-authored more than 300 journal articles and book chapters, and have lectured extensively, both nationally and internationally. I have served on the editorial boards of ten leading medical journals, including the Journal of Clinical Oncology and the Annals of Surgery. I have held several leadership positions related to my commitment to optimal patient care, including past president of the ASCRSRF, co-founder and past president of the Collaborative Group of the Americas on Inherited Colorectal Cancer, and past Chair of MSK’s Surgical Quality Assurance Committee. 

At MSK, caring is at the core of everything we do. We understand that patients and families are going through a very difficult time in their lives. Many of us have been there. Along with an entire team of care providers, I am committed to providing optimal care before, during, and after surgery. I accomplish this by listening to my patients, understanding their individual circumstances, and developing a care plan that best fits their specific diagnosis and needs.

Along with an entire team of care providers, I am committed to providing optimal care before, during, and after surgery.

Dr. Guillem

Awards and Honors

  • Castle Connolly: New York Magazine Top Doctors (2005-2018)


Doctors at Memorial Sloan Kettering work as teams, with specialists from all different areas. This allows us to consider all your needs together, and to give you the best possible care.

Clinical Trials

Smiling doctors in the lab

Find a Clinical Trial for You

Memorial Sloan Kettering's doctors and scientists are constantly developing new treatments for cancer. MSK is typically running hundreds of clinical trials at a given time.

You may be able to participate in a clinical trial even if you are new to MSK. Search our online directory to find trial information and see more about who can participate.

Research and Publications

Guillem JG (2017). The Management of Rectal Cancer in Cameron JL, Cameron AM (12th Edition). Current Surgical Therapy. New York: Elsevier.

Guillem JG. (2015). The Role of Surgery in Cancer Prevention in Devita VT, Lawrence TS, Rosenberg SA (10th Edition). Cancer. Philadelphia: Wolters Klumer.

Guillem JG, Wood WC, Moley JF, Berchuck A, Karlan BY, Mutch DG, Gagel RF, Weitzel J, Morrow M, Weber BL, Giardiello F, Rodriguez-Bigas MA, Church J, Gruber S, Offit K; ASCO; SSO ASCO/SSO review of current role of risk-reducing surgery in common hereditary cancer syndromes. J Clin Oncol. 2006 Oct 1;24(28):4642-60. Review.

Guillem JG, Glogowski E, Moore HG, Nafa K, Markowitz AJ, Shia J, Offit K, Ellis NA. Single-amplicon MSH2 A636P mutation testing in Ashkenazi Jewish patients with colorectal cancer: role in presurgical management. Ann Surg. 2007 Apr;245(4):560-5.

Guillem JG, Lee-Kong SA. Autonomic nerve preservation during rectal cancer resection. J Gastrointest Surg. 2010 Feb;14(2):416-22. doi: 10.1007/s11605-009-0941-4. Epub 2009 Jun 23.

Guillem JG, Puig-La Calle J Jr, Cellini C, Murray M, Ng J, Fazzari M, Paty PB, Quan SH, Wong WD, Cohen AM. Varying features of early age-of-onset “sporadic” and hereditary nonpolyposis colorectal cancer patients. Dis Colon Rectum. 1999 Jan;42(1):36-42. PMID: 10211518.

Publications on PubMed

Visit PubMed for a full listing of Dr. Guillem’s journal articles. Pubmed is an online index of research papers and other articles from the US National Library of Medicine and the National Institutes of Health.