I am a geneticist with expertise in clinical molecular genetics and clinical cytogenetics. My primary specialty is the use of molecular cytogenetics and molecular pathology to diagnose cancer.
Molecular cytogenetics is a continually expanding field due to the rapid progress in cancer genetics research. I closely monitor the new diagnostic and prognostic markers emerging from translational research in order to promptly develop the needed assays for clinical testing of patients.
My investigative research in cancer genetics involves the detection and cloning of new recurrent genomic rearrangements in human cancers. The goal of my work is to identify novel pathogenic molecules that can be used for genetic diagnosis of cancer and lead to improvement in the care of cancer patients.
- Clinical Expertise: Clinical Molecular Genetics and Cancer Cytogenetics
- Languages Spoken: English
- Education: MD, Shandong University School of Medicine (China); PhD, Shanghai Institute of Hematology, Shanghai Second Medical University (China)
- Fellowships: Weill Cornell Medical College; Memorial Sloan Kettering Cancer Center
- Board Certifications: Clinical Molecular Genetics
Wang L, Motoi T, Khanin R, Olshen A, Mertens F, Bridge J, Dal Cin P, Antonescu C, Singer S, Hameed M, Bovee J, Hogendoorn P.C.W., Socci N, Ladanyi M. Identification of a Novel, Recurrent HEY1-NCOA2 Fusion in Mesenchymal Chondrosarcoma based on a Genome-wide Screen of Exon-level Expression Data. Genes Chromosomes & Cancer. 2012 Feb;51(2):127-39.
Chmielecki J, Foo J, Oxnard GR, Hutchinson K, Ohashi K, Somwar R, Wang L, Amato KR, Arcila M, Sos ML, Socci ND, Viale A, de Stanchina E, Ginsberg MS, Thomas RK, Kris MG, Inoue A, Ladanyi M, Miller VA, Michor F, Pao W. Optimization of Dosing for EGFR-Mutant Non-Small Cell Lung Cancer with Evolutionary Cancer Modeling. Sci Transl Med. 2011 Jul 6;3(90):90ra59.
Bott M, Brevet M, Taylor BS, Shimizu S, Ito T, Wang L, Creaney J, Lake RA, Zakowski MF, Reva B, Sander C, Delsite R, Powell S, Zhou Q, Shen R, Olshen A, Rusch V, Ladanyi M. The nuclear deubiquitinase BAP1 is commonly inactivated by somatic mutations and 3p21.1 losses in malignant pleural mesothelioma. Nat Genet. 2011 Jun 5;43(7):668-72.
Yaming Qiao, Lu Wang, Li-Qun Cai, Chen Tan, Julianne Imperato-McGinley, Yuan-Shan Zhu. . Inhibition of Aberrant Androgen Receptor Induction of Prostate Specific Antigen Gene Expression, Cell Proliferation and Tumor Growth by 17a-Estradiol in Prostate Cancer Cases.. Journal of Andrology January 1, 2011; 185(1) :305-14
Ozawa T, Brennan CW, Wang L, Squatrito M, Sasayama T, Nakada M, Huse JT, Pedraza A, Utsuki S, Yasui Y, Tandon A, Fomchenko EI, Oka H, Levine RL, Fujii K, Ladanyi M, Holland EC. PDGFRA gene rearrangements are frequent genetic events in PDGFRA-amplified glioblastomas. Genes & Development. 2010 Oct 1;24(19):2205-18.
Chitale D, Gong Y, Taylor BS, Broderick S, Brennan C, Somwar R, Golas B, Wang L, Motoi N, Szoke J, Reinersman JM, Major J, Sander C, Seshan EV, Zakowski MF, Rusch V, Pao W, Gerald W, Ladanyi M. An integrated genomic analysis of lung cancer reveals loss of DUSP4 in EGFR-mutant tumors. Oncogene. 2009 Aug 6;28(31):2773-83.
Bean J, Brennan C, Shih JY, Riely G, Viale A, Wang L, Chitale D, Motoi N, Szoke J, Broderick S, Balak M, Chang WC, Yu CJ, Gazdar A, Pass H, Rusch V, Gerald W, Huang SF, Yang PC, Miller V, Ladanyi M, Yang CH, Pao W. MET amplification occurs with or without T790M mutations in EGFR mutant lung tumors with acquired resistance to gefitinib or erlotinib. Proc Natl Acad Sci U S A. 2007 Dec 26;104(52):20932-7.
Wang L, Bhargava R, Zheng T, Wexler L, Collins MH, Roulston D, Ladanyi M. Undifferentiated small round cell sarcomas with rare EWS gene fusions: identification of a novel EWS-SP3 fusion and of additional cases with the EWS-ETV1 and EWS-FEV fusions. J Mol Diagn. 2007 Sep;9(4):498-509.
Wang L, Wang YY, Cao Q, Chen B, Chen Z, Chen SJ. Hornerin gene was involved in a case of acute myeloid leukemia transformed from myelodysplastic syndrome with t(1;2)(q21;q37). Leukemia. 2006 Dec; 20(12):2184-7.
Yin X, Han J, Luo T, Wang L, Chen S, Zhao Y, Li X, Jian W, Zheng S, Gu Y, Li G, and Luo M. Cathepsin K in Adipocyte Differentiation and Its Potential Role of the Pathogenesis of Obesity. J Clin Endocrinol Metab. 2006 Nov; 91(11):4520-7.
Zhu YS, Cai LQ, Huang Y, Fish J, Wang L, Zhang ZK, Imperato-McGinley JL . Receptor isoform and ligand-specific modulation of dihydrotestosterone-induced prostate specific antigen gene expression and prostate tumor cell growth by estrogens. Journal of Andrology. 2005 Jul-Aug;26(4):500-8.
Zhao M, Chen B, Wang L, Xu L, Cao Q, Su X, Chen S. Establishment and application of multiplex FISH in detection of the complex chromosome abnormalities in leukemia. Chinese Journal of Medical Genetics. 2002 Oct;19(5):375-8
Li Z, Wang L, Zhang X, Zhang L, Zhang B, Yu Y, Zeng Z, Zhou M, Huang W, Chen Z, Chen S, Li G.. Chromosome aberration analyzed by comparative genomic hybridization in nasopharyngeal carcinoma. Chinese Journal of Medical Genetics. 2001 Oct;18(5):338-42.
Wang G, Zhao Y, Liu X, Wang L, Wu C, Zhang W, Liu W, Zhang P, Cong W, Zhu Y, Zhang L, Chen S, Wan D, Zhao X, Huang W, Gu JR. Allelic loss and gain, but not genomic instability, as the major somatic mutation in primary hepatocellular carcinoma. Genes Chromosomes & Cancer. 2001 Jul;31(3):221-7.
As home to one of the world’s top cancer research centers, Memorial Sloan Kettering is typically involved in more than 900 clinical trials at a given time. Currently, clinical trials focused on the conditions I treat are enrolling new patients. If you’re interested in joining a clinical trial, click to learn about the trial’s purpose, eligibility criteria, and how to get more information.Learn more