I am a board-certified hematologist and oncologist and Chief of the Leukemia Service at Memorial Sloan Kettering Cancer Center.
Memorial Sloan Kettering has a very distinguished history in the development of cutting-edge effective therapies for a wide variety of leukemias. Physicians at Memorial Sloan Kettering were among the first to develop effective therapies for patients with acute lymphoblastic leukemia, acute myeloid leukemia, and acute promyelocytic leukemia.
My clinical expertise is in treating patients with acute myeloid leukemia and acute lymphoblastic leukemia, but I also see patients with the chronic leukemias and myelodysplastic syndromes. My patient-care philosophy is to always imagine every patient as a member of my own family. With this in mind, I know I am going to make the best decisions I can for each patient.
Not all acute and chronic leukemias are alike. As we learn more about these diseases, we are discovering that leukemia cells from different patients have many different genetic abnormalities. My research has been focused on developing novel treatments using drugs that target specific molecular genetic abnormalities in leukemia cells. I am particularly sensitive to the importance of developing new treatments for older adults with leukemia, treatments that are more specific to the leukemia cell and therefore will be less toxic to normal cells so that patients have fewer side effects.
The Leukemia Service at Memorial Sloan Kettering Cancer Center is in an excellent position to take advantage of new findings about the genetic underpinnings of leukemias and to develop new and better treatments. We have many physicians focused on leukemia who have the clinical and laboratory expertise to carry out clinical trials evaluating the effectiveness of new so-called targeted therapies, and we have developed a large number of clinical trials to evaluate these agents.
Before joining Memorial Sloan Kettering, I was on the faculty of Northwestern University Feinberg School of Medicine and the Robert H. Lurie Comprehensive Cancer Center for more than 20 years. There I directed the Leukemia Program, was Co-Director of the Hematologic Malignancy Program at the Robert H. Lurie Comprehensive Cancer Center, and was Associate Chief of the Division of Hematology-Oncology. I completed fellowship training at the Fred Hutchinson Cancer Center and University of Washington at Seattle.
I am an Associate Editor for the journal Blood, the major periodical publishing new information regarding leukemias and other blood disorders. I am currently Chair of the Leukemia Committee of the Eastern Cooperative Oncology Group (ECOG), one of only three large cooperative oncology groups in the US responsible for coordinating large clinical trials of new therapies for patients with all of the acute and chronic leukemias, myelodysplastic syndromes, and myeloproliferative neoplasms. The ECOG, in collaboration with other cooperative oncology groups in the US and around the world, has carried out many important clinical trials which have set the standard of care for the most effective treatment of many of the leukemias and related disorders.
- Clinical Expertise: Acute and Chronic Leukemias; Myelodysplastic Syndromes; Myeloproliferative Neoplasms; Stem Cell Transplantation; Hairy cell Leukemia; Development of New Therapies
- Languages Spoken: English; French
- Education: MD, Chicago Medical School
- Residencies: Evanston Hospital/Northwestern University
- Fellowships: Fred Hutchinson Cancer Research Center/University of Washington
- Board Certifications: Internal Medicine; Medical Oncology; Hematology
Research is integral to our mission at Memorial Sloan Kettering, and clinical trials help us discover better forms of patient care and treatment. For you, this could mean access to a new therapy or therapy combination. Click to see a list of the trials I’m currently leading.
Clinical Trials Led by Martin S. Tallman
- A Phase I Study of EPZ-5676 in Patients with Relapsed/Refractory Leukemia and Other Advanced Hematologic Cancers
- A Phase II Study of Crenolanib plus Chemotherapy in Patients with Newly Diagnosed Acute Myeloid Leukemia with FLT3-Activating Mutations
- A Phase IIA Study of BL-8040 in Patients with Recurrent or Persistent Acute Myeloid Leukemia
Clinical Trials Co-Investigated by Martin S. Tallman
- A Phase I Study of AG-221 in Patients with Advanced Acute Myeloid Leukemia or Myelodysplastic Syndromes with an IDH2 Mutation
- A Phase I Study of BMS-906024 in Adult and Pediatric Patients with Relapsed/Refractory T-Cell Acute Lymphoblastic Leukemia or T-Cell Lymphoblastic Lymphoma
- A Phase I Study of CPI-0610 in Patients with Acute Leukemia, Myelodysplastic Syndromes, or Myelodysplastic/Myeloproliferative Neoplasms
- A Phase I Study of Oral AG-120 to Treat Advanced Acute Myeloid Leukemia or Myelodysplastic Syndromes with an IDH1 Mutation
- A Phase I Study of Ruxolitinib and Decitabine in Patients with Myeloproliferative Neoplasms in Accelerated or Blast Phase
- A Phase I Study of SGN-CD33A in Patients with CD33-Positive Acute Myeloid Leukemia
- A Phase I/II Study of GSK525762 in Patients with Persistent Hematologic Cancers
- A Phase Ib Study of MEK162 plus BYL719 in Patients with Persistent Acute Myeloid Leukemia or Myelodysplastic Syndromes
- A Phase IB Study of MK-3475 in Patients with Myelodysplastic Syndromes and Lymphoma
- A Phase II Study of a Pediatric-Inspired Combination Chemotherapy Regimen in Adults with Acute Lymphoblastic Leukemia
- A Phase II Study of Vemurafenib in Patients with Relapsed or Refractory Hairy Cell Leukemia