Melissa L. Pilewskie, MD, FACS

About Me

I am a surgical breast oncologist whose practice is dedicated to the treatment of breast diseases. I strive to always give my patients compassionate care, both in the clinic and in the operating room, where I perform all aspects of breast cancer surgery, including breast conservation (lumpectomy), mastectomy, nipple-sparing mastectomy, and axillary lymph node procedures. I see patients at the Evelyn H. Lauder Breast Center in Manhattan and at MSK Bergen, in New Jersey. 

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In addition to my clinical practice, I am actively involved in research that aims to continuously improve the care of our breast cancer patients. Some of my previous research has included work on the utilization of breast MRI for women with both invasive and in situ carcinoma and the appropriate surgical treatment for triple-negative breast cancers. 

Currently, I am engaged in research to help personalize screening recommendations for women at high of developing breast cancer, working closely with MSK’s RISE program (Risk assessment, Imaging, Surveillance, and Education). My hope is that my research will enable us to deliver more individualized patient care and screening recommendations in the future. While many women in the RISE program do not require surgery, I counsel and treat women with high-risk breast lesions that do require excision, such as atypical ductal hyperplasia. I also work with many young women who have a genetic predisposition to breast cancer and are interested in undergoing bilateral prophylactic mastectomies for risk reduction. 

Furthermore, I continue to study the appropriate management of ductal carcinoma in situ (DCIS), otherwise known as stage 0 breast cancer. DCIS is currently a controversial topic in medicine. I have worked with my colleagues to assess the risk of finding invasive cancer when surgery is performed for DCIS and to help predict the risk of a recurrence following our standard therapies. Our goal is to better define women with low-risk DCIS who may not require all aspects of breast cancer care. In addition, I am studying novel therapies such as topical medicine and exercise that may provide nontoxic treatment options for patients with DCIS or elevated breast cancer risk.

I work closely with nurse practitioner Margot LeStrange. We combine our expertise to provide comprehensive care to our patients at every step of their cancer journey.

  • Clinical Expertise: Breast Disease
  • Languages Spoken: English
  • Education: MD, Ohio State University
  • Residencies: General Surgery - Northwestern University
  • Fellowships: Breast Surgery - Memorial Sloan Kettering Cancer Center
  • Board Certifications: General Surgery

See My Colleagues


Visit PubMed for a full listing of Melissa L. Pilewskie’s journal articles

Pubmed is an online index of biomedical articles maintained by the U.S. National Library of Medicine and the National Institutes of Health.

Clinical Trials

Research is integral to our mission at Memorial Sloan Kettering, and clinical trials help us discover better forms of patient care and treatment. For you, this could mean access to a new therapy or therapy combination. Click to see a list of the trials I’m currently leading.

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Most major health insurers offer plans that include MSK as one of their in-network providers. If MSK is in-network, it means all our doctors are too. Medicaid and New York State Medicare also provide benefits for care at MSK.

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