As a physician-scientist and specialist in melanoma that has metastasized (spread) to other parts of the body, I care for patients with this cancer in the clinic and search for new therapies to control and cure the disease.
Since joining Memorial Sloan Kettering in 1988, I have diagnosed and treated thousands of patients with metastatic melanoma. This aggressive type of cancer begins in specialized pigment cells and spreads from its original site to lymph nodes, and eventually to other parts of the body.
In the past decade, we have gained significant insights into two areas of melanoma that have led to drug development. The first finding relates to genetic errors contained inside a melanoma cell, and has enabled the development of drugs that target these errors. The second is an expanded understanding of how the body’s immune system can recognize cancers like melanoma. From this we have learned how to activate a vigorous immune response against the disease.
In an advance that helped to launch a new era of personalized medicine in melanoma treatment, I led a clinical trial that partially paved the way for the 2011 approval of vemurafenib (Zelboraf®), by the US Food and Drug Administration. This drug targets a mutation in a gene called BRAF, which is present in about half of patients who have metastatic melanoma. We also learned that a small proportion of melanomas have mutations in other genes, some of which we can target with different drugs.
In addition, I was one of five Memorial Sloan Kettering scientists recently appointed to a melanoma “Dream Team” sponsored by the nonprofit organization Stand Up To Cancer and the Melanoma Research Alliance. This team’s project focuses on identifying potential therapies for metastatic melanoma patients who do not have the mutated form of the BRAF gene.
My collaboration with Memorial Sloan Kettering colleagues led to the 2011 FDA approval of the monoclonal antibody ipilimumab (Yervoy™), which prompts the body’s immune system to recognize cancers like melanoma as foreign. I also am working to develop vaccines against melanoma that we hope can be used to direct the patient’s immune system against melanoma cells that may remain following successful treatment.
In addition to my work at Memorial Sloan Kettering, I am a professor of medicine at the Weill Cornell Medical College and am active in a number of scientific organizations such as the American Association for Cancer Research, the Society for Melanoma Research, and the American Society of Clinical Oncology. I also serve as the chair of the Melanoma Research Alliance Medical Advisory Panel.
I am proud to have received a number of honors and awards for my clinical research, such as the Wings of Hope Award in 2007 from the Melanoma Research Foundation.
- Clinical Expertise: Melanoma; Immunotherapy; Cancer Vaccines; Novel Targeted Therapy for Melanoma; Chemotherapy
- Languages Spoken: English
- Education: MD, Cornell University Medical College
- Residencies: University of Chicago Hospitals and Clinics
- Fellowships: Memorial Sloan Kettering Cancer Center
- Board Certifications: Internal Medicine; Medical Oncology
Research is integral to our mission at Memorial Sloan Kettering, and clinical trials help us discover better forms of patient care and treatment. For you, this could mean access to a new therapy or therapy combination. Click to see a list of the trials I’m currently leading.
Clinical Trials Led by Paul B. Chapman
- A Phase I Study of AEB071 and BYL719 in Patients with Metastatic Uveal Melanoma
- A Phase II Study of Crizotinib in Patients with High-Risk Uveal Melanoma
- A Phase II Study of Dabrafenib After Surgery in Patients with BRAF V600 Mutation-Positive Stage IIIC Melanoma
- A Phase II Study of Trametinib with and without GSK2141795 in Patients with Advanced Uveal Melanoma
- An Expanded Access Program with Nivolumab and Ipilimumab for Patients with Inoperable or Metastatic Melanoma
Clinical Trials Co-Investigated by Paul B. Chapman
- A Phase II Study of LEE011 plus MEK162 in Patients with NRAS-Mutant Melanoma
- A Phase II Study of LGX818 plus MEK162, Followed by Another Targeted Drug If Needed, in Patients with Locally Advanced or Metastatic Melanoma with a BRAF Mutation
- A Phase II Study of RAD001 (Everolimus) and Pasireotide (SOM230)) in Patients with Advanced Uveal Melanoma
- A Phase II Study of Vorinostat for Metastatic Uveal Melanoma