
Paul B. Chapman, MD
Melanoma Oncologist
Titles
Attending Physician
Clinical Expertise
Melanoma; Immunotherapy; Cancer Vaccines; Novel Targeted Therapy for Melanoma; Chemotherapy
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New Patient Appointments
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Dr. Chapman accepts the following list of insurance providers. Select your insurance provider to see more details.
Payor Type: Commercial
In Network Coverage Type(s): HMO, EPO PPO, POS, Transplant
Payor Type: Medicare/Medicare Advantage
In Network Coverage Type(s): PPO
Payor Type: Commercial
In Network Coverage Type(s): HMO, PPO
Payor Type: Commercial
In Network Coverage Type(s): PPO, POS, EPO, HMO
Payor Type: Commercial
In Network Coverage Type(s): HMO, EPO PPO, POS
Payor Type: Medicaid/Managed Medicaid
In Network Coverage Type(s): HMO
Payor Type: Commercial
In Network Coverage Type(s): Supplemental
Payor Type: Commercial
In Network Coverage Type(s): PPO, POS, HMO
Payor Type: Commercial
In Network Coverage Type(s): POS, EPO, HMO
Payor Type: Commercial
In Network Coverage Type(s): PPO, POS, EPO, HMO
Payor Type: Medicaid/Managed Medicaid
In Network Coverage Type(s): HMO
Payor Type: Medicare/Medicare Advantage
In Network Coverage Type(s): PPO, HMO
Payor Type: Medicare/Medicare Advantage
In Network Coverage Type(s): PPO, HMO, DSN
Payor Type: Medicaid/Managed Medicaid
In Network Coverage Type(s): HMO
Payor Type: Commercial
In Network Coverage Type(s): PPO
Payor Type: Commercial
In Network Coverage Type(s): HMO, EPO
Payor Type: Medicaid/Managed Medicaid
In Network Coverage Type(s): HMO
Payor Type: Medicare/Medicare Advantage
In Network Coverage Type(s): HMO
Payor Type: Medicare/Medicare Advantage
In Network Coverage Type(s): PPO
Payor Type: Commercial
In Network Coverage Type(s): EPO, HMO, PPO, POS
Payor Type: Medicaid/Managed Medicaid
In Network Coverage Type(s): HMO
Payor Type: Medicare/Medicare Advantage
In Network Coverage Type(s): HMO, PPO
Payor Type: Commercial
In Network Coverage Type(s): PPO EPO
Payor Type: Commercial
In Network Coverage Type(s): HMO
Payor Type: Commercial
In Network Coverage Type(s): PPO
Payor Type: Commercial
In Network Coverage Type(s): EPO
Payor Type: Commercial
In Network Coverage Type(s): EPO
Payor Type: Medicare/Medicare Advantage
In Network Coverage Type(s): PPO, HMO
Payor Type: Medicaid/Managed Medicaid
In Network Coverage Type(s): State Government
Payor Type: Commercial
In Network Coverage Type(s): PPO, POS, EPO
Payor Type: Medicaid/Managed Medicaid
In Network Coverage Type(s): State Government
Payor Type: Medicaid/Managed Medicaid
In Network Coverage Type(s): State Government
Payor Type: Medicare/Medicare Advantage
In Network Coverage Type(s): Federal Government
Payor Type: Commercial
In Network Coverage Type(s): Supplemental
Payor Type: Commercial
In Network Coverage Type(s): PPO/OAP
Payor Type: Other
In Network Coverage Type(s): PPO, POS, EPO, HMO
Payor Type: Medicare/Medicare Advantage
In Network Coverage Type(s): TBD
Payor Type: Commercial
In Network Coverage Type(s): HMO/EPO
Payor Type: Commercial
In Network Coverage Type(s): PPO, EPO
Payor Type: Commercial
In Network Coverage Type(s): State Government
Payor Type: Commercial
In Network Coverage Type(s): PPO, POS, HMO
Payor Type: Commercial
In Network Coverage Type(s): PPO, HMO
Payor Type: Commercial
In Network Coverage Type(s): PPO, POS
Payor Type: Commercial
In Network Coverage Type(s): PPO, POS, HMO
Contact and Location
- 646-888-4162 Office Phone
- Speaks English

Memorial Sloan Kettering has locations throughout New York City, Long Island, New Jersey, and Westchester. These locations offer many services, including screening, chemotherapy, and medical testing.
See all locationsAbout Me
Education
MD, Cornell University Medical College
Residencies
Internal Medicine - University of Chicago Hospitals and Clinics
Fellowships
Medical Oncology - Memorial Sloan Kettering Cancer Center
Board Certifications
Internal Medicine; Medical Oncology
As a physician-scientist and specialist in melanoma that has metastasized (spread) to other parts of the body, I care for patients with this cancer in the clinic and search for new therapies to control and cure the disease.
Read more
Since joining Memorial Sloan Kettering in 1988, I have diagnosed and treated thousands of patients with metastatic melanoma. This aggressive type of cancer begins in specialized pigment cells and spreads from its original site to lymph nodes, and eventually to other parts of the body.
In the past decade, we have gained significant insights into two areas of melanoma that have led to drug development. The first finding relates to genetic errors contained inside a melanoma cell, and has enabled the development of drugs that target these errors. The second is an expanded understanding of how the body’s immune system can recognize cancers like melanoma. From this we have learned how to activate a vigorous immune response against the disease.
In an advance that helped to launch a new era of personalized medicine in melanoma treatment, I led a clinical trial that partially paved the way for the 2011 approval of vemurafenib (Zelboraf®), by the US Food and Drug Administration. This drug targets a mutation in a gene called BRAF, which is present in about half of patients who have metastatic melanoma. We also learned that a small proportion of melanomas have mutations in other genes, some of which we can target with different drugs.
In addition, I was one of five Memorial Sloan Kettering scientists recently appointed to a melanoma “Dream Team” sponsored by the nonprofit organization Stand Up To Cancer and the Melanoma Research Alliance. This team’s project focuses on identifying potential therapies for metastatic melanoma patients who do not have the mutated form of the BRAF gene.
My collaboration with Memorial Sloan Kettering colleagues led to the 2011 FDA approval of the monoclonal antibody ipilimumab (Yervoy™), which prompts the body’s immune system to recognize cancers like melanoma as foreign. I also am working to develop vaccines against melanoma that we hope can be used to direct the patient’s immune system against melanoma cells that may remain following successful treatment.
In addition to my work at Memorial Sloan Kettering, I am a professor of medicine at the Weill Cornell Medical College and am active in a number of scientific organizations such as the American Association for Cancer Research, the Society for Melanoma Research, and the American Society of Clinical Oncology. I also serve as the chair of the Melanoma Research Alliance Medical Advisory Panel.
I am proud to have received a number of honors and awards for my clinical research, such as the Wings of Hope Award in 2007 from the Melanoma Research Foundation.
Awards and Honors
- Castle Connolly: America's Top Doctors (2023)
- Castle Connolly: New York Magazine Top Doctors (2002-2008, 2011-2020)
Colleagues
Doctors at Memorial Sloan Kettering work as teams, with specialists from all different areas. This allows us to consider all your needs together, and to give you the best possible care.
Clinical Trials
- Clinical Trials Investigated by Dr. Chapman
- A Phase IB Study of Belvarafenib Alone and in Combination with Cobimetinib in People with Advanced Melanoma Who Had Immunotherapy
- Clinical Trials Co-Investigated by Dr. Chapman
- A Phase I Study of FHD-286 in People with Uveal Melanoma
- A Phase I/II Study of DYP688 for People with Advanced Uveal Melanoma and Other Melanomas with GNAQ/11 Gene Mutations
- A Pilot Study of Stool Transplant to Control Immunotherapy-Related Diarrhea

Memorial Sloan Kettering's doctors and scientists are constantly developing new treatments for cancer. MSK is typically running hundreds of clinical trials at a given time.
You may be able to participate in a clinical trial even if you are new to MSK. Search our online directory to find trial information and see more about who can participate.
Search clinical trialsResearch and Publications
Visit PubMed for a full listing of Dr. Chapman’s journal articles. Pubmed is an online index of research papers and other articles from the US National Library of Medicine and the National Institutes of Health.
See all on PubMedPatient Reviews
At MSK, we’re committed to delivering the best care to every patient. We use feedback from our patients to continue to improve our care. We also post patient reviews online to help you make healthcare choices. Learn more about our patient experience reviews.
Disclosures
Doctors and faculty members often work with pharmaceutical, device, biotechnology, and life sciences companies, and other organizations outside of MSK, to find safe and effective cancer treatments, to improve patient care, and to educate the health care community.
MSK requires doctors and faculty members to report (“disclose”) the relationships and financial interests they have with external entities. As a commitment to transparency with our community, we make that information available to the public.
Paul B. Chapman discloses the following relationships and financial interests:
-
Merck & Co Inc.
Provision of Services
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MolecularMD Corp.
Ownership / Equity Interests
If you’re a patient at MSK and would like more information about your doctor’s external relationships, please talk with your doctor.
The information published here is for a specific annual disclosure period. There may be differences between information on this and other public sites as a result of different reporting periods and/or the various ways relationships and financial interests are categorized by organizations that publish such data.
This page and data include information for a specific MSK annual disclosure period (January 1, 2021 through disclosure submission in spring 2022). This data reflects interests that may or may not still exist. This data is updated annually.
Learn more about MSK’s COI policies here. For questions regarding MSK’s COI-related policies and procedures, email MSK’s Compliance Office at [email protected].