Sam S. Yoon, MD

Sam S. Yoon, MD

Surgical Oncologist

Clinical Expertise

Sarcomas and Other Soft Tissue Tumors; Gastric (Stomach) Cancer; Small Bowel Tumors; Neuroendocrine Tumors; Lymphoma and Spleen Tumors; Adrenal Tumors; Melanoma

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Dr. Yoon accepts the following list of insurance providers. Select your insurance provider to see more details.

Contact and Location

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Memorial Sloan Kettering has locations throughout New York City, Long Island, New Jersey, and Westchester. These locations offers many services, including screening, chemotherapy, and medical testing.

About Me


MD, University of California San Diego


General Surgery - Massachusetts General Hospital


Surgical Oncology - Memorial Sloan Kettering Cancer Center

Board Certifications


I am a surgical oncologist who specializes in caring for people with stomach (gastric) cancer and gastroesophageal junction (GEJ) tumors, sarcomas, and soft-tissue tumors. I also have expertise in treating  patients with tumors of the duodenum, small intestine, adrenal gland, neuroendocrine system, spleen, and lymph nodes. I work primarily at Memorial Sloan Kettering’s Manhattan location but also see patients at Memorial Sloan Kettering Basking Ridge and MSK Monmouth in New Jersey.

My main goal is to provide each patient with the absolute best care for his or her particular disease. I work closely with medical oncologists, radiation oncologists, pathologists, and other medical professionals who specialize in the diagnosis and treatment of patients with gastric/gastroesophageal junction cancer and sarcomas. I feel it’s important, even for experienced surgeons, to constantly improve and expand one’s surgical skills. For me, this has involved early adoption of new laparoscopic and minimally invasive techniques, such as robot-assisted resection of gastric, adrenal, and other intra-abdominal tumors. I’ve performed over 100 minimally invasive robot-assisted procedures using the da Vinci Surgical System, which allows for smaller incisions, more precise operations, and faster recovery. 

I have performed clinical and laboratory research throughout my career and am the author of more than 150 peer-reviewed articles, reviews, and book chapters. Many of these publications describe the treatment and outcome of patients with various sarcomas (e.g. retroperitoneal and pelvic sarcomas, extremity and trunk sarcomas, and angiosarcomas) and gastrointestinal cancers (e.g. gastric adenocarcinoma, hereditary diffuse gastric cancer syndrome, gastrointestinal stromal tumors, and colorectal cancer liver metastases). I am on the editorial board of medical journals, such as the Annals of Surgical Oncology and the Journal of Gastrointestinal Surgery and serve on several national committees, including the American Joint Commission on Cancer Soft Tissue Sarcoma Expert Panel.

I am the principal investigator for a research laboratory that examines the role of tumor blood vessels and cancer stem cells in controlling the growth, spread, and treatment response of gastric cancers and sarcomas. My laboratory is currently funded by an R01 grant from the National Cancer Institute as well as other foundation and society grants. We previously completed a clinical trial examining the role of bevacizumab (Avastin®), a drug that inhibits vascular endothelial growth factor A (VEGF-A), and radiation in the pre-operative treatment of resectable sarcomas. Bevacizumab markedly improved the tumor-killing effects of radiation, and this trial served as the basis for an ongoing multi-institutional trial of VEGF-A inhibition and radiation run by the Children’s Oncology Group and the Radiation Therapy Oncology Group. More recently, we have found that inhibiting cancer stem cells improves the effectiveness of standard chemotherapies, and we are currently developing clinical trials in this area.


Doctors at Memorial Sloan Kettering work as teams, with specialists from all different areas. This allows us to consider all your needs together, and to give you the best possible care.

Clinical Trials

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Find a Clinical Trial for You

Memorial Sloan Kettering's doctors and scientists are constantly developing new treatments for cancer. MSK is typically running hundreds of clinical trials at a given time.

You may be able to participate in a clinical trial even if you are new to MSK. Search our online directory to find trial information and see more about who can participate.

Research and Publications

View Dr. Yoon's Lab

Selected Book Chapters
“Surgical management of metastatic colon and rectal cancer.” Yoon SS, Tanabe KK. In: American Cancer Society Atlas of Clinical Oncology: Cancer of the Lower Gastrointestinal Tract. Steele GD, Phillips TL, Chabner BA, eds. Willet C, series ed.  Hamilton, Ontario, CA: BC Decker Inc., 2001; 170-195.

“Surgical and regional therapy for liver metastases.” Tanabe KK, Yoon SS. In: Oncology: An Evidence Based Approach. Chang AE, Ganz PA, Hayes DF, Kinsella TJ, Pass HI, Schiller JH, Stone RM, Strecher VJ, eds. New York: Springer-Verlag, 2006; 1636-1654.

“Benign liver tumors.” Yoon SS, Tanabe KK. In: Advanced Therapy in Surgical Oncology. Pollock RE, Curley SA, Ross MI, Perrior ND, eds. Hamilton, British Columbia: Decker, 2007; 131-142.

“Soft tissue sarcomas.” DeLaney TF, Hornicek FJ, Kirsch DG, Yoon SS, Rosenberg AE, Harmon DC, Mankin HJ, Rosenthal D, Suit HD.  In: Treatment of Cancer. Price P, Sikora K, Illidge T, eds. Oxford, UK: Oxford University Press, 2008.

“Soft tissue and bone sarcomas.” Yoon SS, Hornicek FJ, Harmon DC, DeLaney TF.  In: Harrison’s Handbook of Medical Oncology. Chabner BA, Lynch TJ, Longo DL, eds.  New York: McGraw Hill, 2008; 549-566.

“Hereditary diffuse gastric cancer.” Pandalai PK, Yoon SS. In: Principles of Clinical Cancer Genetics. Chung DC, Haber DA, eds. New York: Springer, 2010; 97-107.

“The management of soft tissue sarcoma.” Yoon SS, Hornicek FJ.  In: Current Surgical Therapy. 10th ed. Cameron JL, Cameron AM, eds. Philadelphia: Elsevier, 2011; 631-636.

“Radiation therapy for desmoid tumors.” El Halabi HO, Chen YL, Mullen JT, Yoon SS, Hornicek FJ, DeLaney TF. In: Desmoid Tumors. Litchman CD, ed. New York: Springer, 2012; 105-126.

“Soft tissue and bone sarcomas.” Yoon SS, Hornicek FJ, Choy E, DeLaney TF. In: Harrison’s Handbook of Medical Oncology. 2nd ed. Chabner BA, Lynch TJ, Longo DL, eds. New York: McGraw Hill (in press).

“The management of gastric adenocarcinoma.” Yoon SS. In: Current Surgical Therapy, 11th ed. Cameron JL, Cameron AM. Philadelphia: Elsevier (in press).


Publications on PubMed

Visit PubMed for a full listing of Dr. Yoon’s journal articles. Pubmed is an online index of research papers and other articles from the US National Library of Medicine and the National Institutes of Health.