Samuel F. Bakhoum, MD, PhD

About Me

  • Clinical Expertise: Breast Cancer
  • Awards and Honors: Josie Robertson Investigator (2018-2023); Blavatnik Regional Awards for Young Scientists, Finalist (2018); Tri-Institutional Breakout Prize (2018); Burroughs Wellcome Fund Career Award for Medical Scientists (2018); NextGen Stars, American Association for Cancer Research (2018); Breast Cancer Breakthrough Award, Department of Defense (2016); ASCI/AAP Outstanding Young Investigator Award (2011); Norton B. Gilula Award, the American Society for Cell Biology (2008)
  • Languages Spoken: English
  • Education: MD, Dartmouth Medical School; PhD, Dartmouth College
  • Residencies: Radiation Oncology - Memorial Sloan Kettering Cancer Center

My Research

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See Samuel F. Bakhoum’s laboratory
research at Memorial Sloan Kettering.


Bakhoum SF (corresponding author), Cantley LC (2018) The multifaceted role of chromosomal instability in cancer and its microenvironment. Cell: 174: 1347-1360

Bakhoum SF*, Ngo B*, Laughney AM, Cavallo JA, Murphy CJ, Ly P, Shah P, Sriram RK, Watkins TBK, Taunk NK, Duran M, Pauli C, Shaw C, Chadalavada K, Rajasekhar VK, Genovese G, Venkatesan S, BirkBak NJ, McGranahan N, Lundquist M, Laplant Q, Healy JH, Elemento O, Chung CH, Lee NY, Imielenski M, Nanjangud G, Pe’er D, Cleveland D, Powell SN, Lammerding J, Swanton C, Cantley LC (2018) Chromosomal Instability drives metastasis through a cytosolic DNA response. Nature: 553, 467-472. PMID: 29342134

Laughney AM, Elizalde S, Genovese G, Bakhoum SF (corresponding author) (2015) Dynamics of tumor heterogeneity derived from clonal karyotypic evolution. Cell Reports: 12, 809-820. PMID: 26212324

Bakhoum SF (corresponding author), Kabeche L, Wood MD, Laucius CD, Qu D, Laughney AM, Louie RJ, Phillips J, Chan DA, Petritsch C, Zaki BI, Murnane JP, Compton DA (2015) Numerical chromosomal instability mediates susceptibility to radiation treatment. Nature Communications: 6, 5990. PMID: 25606712

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Visit PubMed for a full listing of Samuel F. Bakhoum’s journal articles

Pubmed is an online index of biomedical articles maintained by the U.S. National Library of Medicine and the National Institutes of Health.

Clinical Trials

As home to one of the world’s top cancer research centers, Memorial Sloan Kettering is typically involved in more than 900 clinical trials at a given time. Currently, clinical trials focused on the conditions I treat are enrolling new patients. If you’re interested in joining a clinical trial, click to learn about the trial’s purpose, eligibility criteria, and how to get more information.

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Most major health insurers offer plans that include MSK as one of their in-network providers. If MSK is in-network, it means all our doctors are too. Medicaid and New York State Medicare also provide benefits for care at MSK.

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