Samuel F. Bakhoum, MD, PhD

Radiation Oncologist

Conditions Treated

Memorial Sloan Kettering radiation oncologist Samuel Bakhoum
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About Me

I am a radiation oncologist who specializes in caring for people with breast cancer. My practice is located at Memorial Hospital in Manhattan. I am also a researcher who is working to understand more about how cancer grows and spreads. Ultimately, my goal is for this knowledge to help develop more effective treatments for our patients.

Being a cancer doctor at MSK means I have the opportunity to be a member of a team that draws on a wide range of expertise from a variety of disciplines. I also have the privilege of connecting with my patients and their families on many levels. This includes caring for their emotional well-being while using the most cutting-edge scientific knowledge to guide their treatment. Each person I care for is unique and deserves a personalized treatment plan for their specific needs.

In addition, I conduct research into how cancer can change its genetic makeup to evade treatments and spread to distant organs. One genetic error that has been linked to cancer aggressiveness and resistance to treatment is called chromosomal instability (CIN). My lab is dedicated to learning about CIN and using this information for therapies that tackle aggressive cancers and their ability to spread.

When I meet with my patients, I hope they leave with a sense of control and confidence in the treatment we have carefully planned for them. By having a full understanding of all the options available, patients can overcome the emotional challenges of a cancer diagnosis and feel positive and hopeful about their treatment outcome.

  • Clinical Expertise: Breast Cancer
  • Awards and Honors: Josie Robertson Investigator (2018-2023); Blavatnik Regional Awards for Young Scientists, Finalist (2018); Tri-Institutional Breakout Prize (2018); Burroughs Wellcome Fund Career Award for Medical Scientists (2018); NextGen Stars, American Association for Cancer Research (2018); Breast Cancer Breakthrough Award, Department of Defense (2016); ASCI/AAP Outstanding Young Investigator Award (2011); Norton B. Gilula Award, the American Society for Cell Biology (2008)
  • Languages Spoken: English
  • Education: MD, Dartmouth Medical School; PhD, Dartmouth College
  • Residencies: Radiation Oncology - Memorial Sloan Kettering Cancer Center

My Research

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See Samuel F. Bakhoum’s laboratory
research at Memorial Sloan Kettering.


Bakhoum SF (corresponding author), Cantley LC (2018) The multifaceted role of chromosomal instability in cancer and its microenvironment. Cell: 174: 1347-1360

Bakhoum SF*, Ngo B*, Laughney AM, Cavallo JA, Murphy CJ, Ly P, Shah P, Sriram RK, Watkins TBK, Taunk NK, Duran M, Pauli C, Shaw C, Chadalavada K, Rajasekhar VK, Genovese G, Venkatesan S, BirkBak NJ, McGranahan N, Lundquist M, Laplant Q, Healy JH, Elemento O, Chung CH, Lee NY, Imielenski M, Nanjangud G, Pe’er D, Cleveland D, Powell SN, Lammerding J, Swanton C, Cantley LC (2018) Chromosomal Instability drives metastasis through a cytosolic DNA response. Nature: 553, 467-472. PMID: 29342134

Laughney AM, Elizalde S, Genovese G, Bakhoum SF (corresponding author) (2015) Dynamics of tumor heterogeneity derived from clonal karyotypic evolution. Cell Reports: 12, 809-820. PMID: 26212324

Bakhoum SF (corresponding author), Kabeche L, Wood MD, Laucius CD, Qu D, Laughney AM, Louie RJ, Phillips J, Chan DA, Petritsch C, Zaki BI, Murnane JP, Compton DA (2015) Numerical chromosomal instability mediates susceptibility to radiation treatment. Nature Communications: 6, 5990. PMID: 25606712

Visit PubMed for a full listing of Samuel F. Bakhoum’s journal articles

Pubmed is an online index of biomedical articles maintained by the U.S. National Library of Medicine and the National Institutes of Health.

Clinical Trials

As home to one of the world’s top cancer research centers, Memorial Sloan Kettering is typically involved in more than 900 clinical trials at a given time. Currently, clinical trials focused on the conditions I treat are enrolling new patients. If you’re interested in joining a clinical trial, click to learn about the trial’s purpose, eligibility criteria, and how to get more information.

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Most major health insurers offer plans that include MSK as one of their in-network providers. If MSK is in-network, it means all our doctors are too. Medicare and New York State Medicaid also provide benefits for care at MSK.

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