Samuel F. Bakhoum, MD, PhD
Radiation Oncologist
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About Me
- Assistant Attending Radiation Oncologist
I am a radiation oncologist who specializes in caring for people with breast cancer. My practice is located at Memorial Hospital in Manhattan.
I am also a researcher who is working to understand more about how cancer grows and spreads. Ultimately, my goal is for this knowledge to help develop more effective treatments for our patients.
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Being a cancer doctor at MSK means I have the opportunity to be a member of a team that draws on a wide range of expertise from a variety of disciplines. I also have the privilege of connecting with my patients and their families on many levels. This includes caring for their emotional well-being while using the most cutting-edge scientific knowledge to guide their treatment. Each person I care for is unique and deserves a personalized treatment plan for their specific needs.
In addition, I conduct research into how cancer can change its genetic makeup to evade treatments and spread to distant organs. One genetic error that has been linked to cancer aggressiveness and resistance to treatment is called chromosomal instability (CIN). My lab is dedicated to learning about CIN and using this information for therapies that tackle aggressive cancers and their ability to spread.
When I meet with my patients, I hope they leave with a sense of control and confidence in the treatment we have carefully planned for them. By having a full understanding of all the options available, patients can overcome the emotional challenges of a cancer diagnosis and feel positive and hopeful about their treatment outcome.
My Specialties
- Breast Cancer
Education
- MD, Dartmouth Medical School
- PhD, Dartmouth College
Residencies
- Radiation Oncology - Memorial Sloan Kettering Cancer Center
Awards and Honors
- Finalist, BioInnovation Institute & Science Magazine Prize (2023)
- Emerging Leader Award, Mark Foundation for Cancer Research (2023)
- Josie Robertson Investigator (2018-2023)
- National Institutes of Health Director’s Early Independence Award (2018-2023)
- 20 Under 40: Next Generation of Biotech Leaders, Endpoint News (2022)
- Blavatnik Regional Awards for Young Scientists, Finalist (2018)
- Tri-Institutional Breakout Prize (2018)
- Burroughs Wellcome Fund Career Award for Medical Scientists (2018)
- NextGen Stars, American Association for Cancer Research (2018)
- Breast Cancer Breakthrough Award, Department of Defense (2016)
- ASCI/AAP Outstanding Young Investigator Award (2011)
- Norton B. Gilula Award, the American Society for Cell Biology (2008)
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Contact and Location
Dr. Bakhoum sees patients at one location.
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Colleagues
Doctors at Memorial Sloan Kettering work as teams, with specialists from all different areas. This allows us to consider all your needs together, and to give you the best possible care.
See all External Beam Radiotherapy Service, Manhattan doctors
Clinical Trials
- Clinical Trials Co-Investigated by Dr. Bakhoum
- A Phase II Study of Radiation Therapy with Pembrolizumab Immunotherapy and Olaparib in Women with Triple-Negative Breast Cancer
Memorial Sloan Kettering's doctors and scientists are constantly developing new treatments for cancer. MSK is typically running hundreds of clinical trials at a given time.
You may be able to participate in a clinical trial even if you are new to MSK. Search our online directory to find trial information and see more about who can participate.
Search clinical trialsResearch and Publications
View a list of Dr. Bakhoum’s publications.
Agustinus AS, Al-Rawi D, Dameracharla B, Raviram R, Jones BS, Stransky S, Scipioni L, Luebeck J, Di Bona M, Norkunaite D, Myers RM, Duran M, Choi S, Weigelt B, Yomtoubian S, McPherson A, Toufektchan E, Keuper K, Mischel PS, Mittal V, Shah SP, Maciejowski J, Storchova Z, Gratton E, Ly P, Landau DA, Bakhoum MF, Koche RP, Sidoli S, Bafna V, David Y*, Bakhoum SF* (2023) Epigenetic dysregulation from chromosomal transit in micronuclei. Nature. Accepted in press.
Li J, Duran MA, Dhanota N, Chatila WK, Bettigole SE, Kwon J, Sriram RK, Humphries MP, Salto-Tellez M, James JA, Hanna MG, Melms JC, Vallabhaneni S, Litchfield K, Usaite I, Biswas D, Bareja R, Li HW, Martin ML, Dorsaint P, Cavallo JA, Li P, Pauli C, Gottesdiener L, DiPardo BJ, Hollmann TJ, Merghoub T, Wen HY, Reis-Filho JS, Riaz N, Su SM, Kalbasi A, Vasan N, Powell SN, Wolchok JD, Elemento O, Swanton C, Shoushtari AN, Parkes EE, Izar B, Bakhoum SF. Metastasis and Immune Evasion from Extracellular cGAMP Hydrolysis. Cancer Discov. 2021 May;11(5):1212-1227. doi: 10.1158/2159-8290.CD-20-0387. Epub 2020 Dec 28. PMID: 33372007; PMCID: PMC8102348.
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Bakhoum SF, Cantley LC. The Multifaceted Role of Chromosomal Instability in Cancer and Its Microenvironment. Cell. 2018 Sep 6;174(6):1347-1360. doi: 10.1016/j.cell.2018.08.027. PMID: 30193109; PMCID: PMC6136429.
Bakhoum SF, Ngo B, Laughney AM, Cavallo JA, Murphy CJ, Ly P, Shah P, Sriram RK, Watkins TBK, Taunk NK, Duran M, Pauli C, Shaw C, Chadalavada K, Rajasekhar VK, Genovese G, Venkatesan S, Birkbak NJ, McGranahan N, Lundquist M, LaPlant Q, Healey JH, Elemento O, Chung CH, Lee NY, Imielenski M, Nanjangud G, Pe’er D, Cleveland DW, Powell SN, Lammerding J, Swanton C, Cantley LC. Chromosomal instability drives metastasis through a cytosolic DNA response. Nature. 2018 Jan 25;553(7689):467-472. doi: 10.1038/nature25432. Epub 2018 Jan 17. PMID: 29342134; PMCID: PMC5785464.
Laughney AM, Elizalde S, Genovese G, Bakhoum SF. Dynamics of Tumor Heterogeneity Derived from Clonal Karyotypic Evolution. Cell Rep. 2015 Aug 4;12(5):809-20. doi: 10.1016/j.celrep.2015.06.065. Epub 2015 Jul 23. PMID: 26212324.
Bakhoum SF, Kabeche L, Wood MD, Laucius CD, Qu D, Laughney AM, Reynolds GE, Louie RJ, Phillips J, Chan DA, Zaki BI, Murnane JP, Petritsch C, Compton DA. Numerical chromosomal instability mediates susceptibility to radiation treatment. Nat Commun. 2015 Jan 21;6:5990. doi: 10.1038/ncomms6990. PMID: 25606712; PMCID: PMC4516720.
Visit PubMed for a full listing of Dr. Bakhoum’s journal articles. Pubmed is an online index of research papers and other articles from the US National Library of Medicine and the National Institutes of Health.
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Disclosures
Doctors and faculty members often work with pharmaceutical, device, biotechnology, and life sciences companies, and other organizations outside of MSK, to find safe and effective cancer treatments, to improve patient care, and to educate the health care community.
MSK requires doctors and faculty members to report (“disclose”) the relationships and financial interests they have with external entities. As a commitment to transparency with our community, we make that information available to the public.
Samuel F. Bakhoum discloses the following relationships and financial interests:
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Meliora Therapeutics
Equity; Professional Services and Activities
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Volastra Therapeutics Inc.
Equity; Fiduciary Role / Position; Intellectual Property Rights; Professional Services and Activities
If you’re a patient at MSK and would like more information about your doctor’s external relationships, please talk with your doctor.
The information published here is for a specific annual disclosure period. There may be differences between information on this and other public sites as a result of different reporting periods and/or the various ways relationships and financial interests are categorized by organizations that publish such data.
This page and data include information for a specific MSK annual disclosure period (January 1, 2022 through disclosure submission in spring 2023). This data reflects interests that may or may not still exist. This data is updated annually.
Learn more about MSK’s COI policies here. For questions regarding MSK’s COI-related policies and procedures, email MSK’s Compliance Office at [email protected].
