Steven D. Leach, MD


Director, David M. Rubenstein Center for Pancreatic Cancer Research

Conditions Treated:

Pictured: Steven Leach

About Me

I am an Attending Physician at Memorial Sloan Kettering, Professor of Surgery at Weill-Cornell Medical College, and Director of Memorial Sloan Kettering’s new David M. Rubenstein Center for Pancreatic Cancer Research. Prior to this I was Professor of Surgery, Oncology and Cell Biology, and the Paul K. Neumann Professor in Pancreatic Cancer at Johns Hopkins.

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My lab has a long track record of research productivity in the field of pancreatic cancer biology, and is known for establishing important links between pancreatic development and pancreatic cancer. These include the discovery of abnormal Notch pathway activation as an important driver of pancreatic tumorigenesis, development of the first zebrafish model of pancreatic cancer, identification of adult acinar cells as effective cells of origin for the initiation of pancreatic “ductal” neoplasia, and the recent discovery of a new stem cell associated with the earliest pre-invasive stages of the disease. Together with our extensive additional studies of pancreatic development and pancreatic epithelial plasticity, work from my group has generated important new insights regarding early events in human pancreatic cancer, including the likelihood that pancreatic ductal adenocarcinoma will arise from non-ductal cells of origin.

I also have extensive administrative experience, including the management of large multi-investigator and multi-institutional research initiatives. I previously served as both Chief of the Division of Surgical Oncology and Vice Chair for Academic Affairs in the Department of Surgery at Johns Hopkins, and I also serve on the Princeton University Board of Trustees.

  • Clinical Expertise: Multidisciplinary management of pancreatic cancer
  • Languages Spoken: English
  • Education: MD, Emory University School of Medicine
  • Residencies: Yale New Haven Hospital
  • Fellowships: Yale University School of Medicine; MD Anderson Cancer Center
  • Board Certifications: General Surgery

My Research

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See Steven D. Leach’s laboratory
research at Memorial Sloan Kettering.

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Visit PubMed for a full listing of Steven D. Leach’s journal articles

Pubmed is an online index of biomedical articles maintained by the U.S. National Library of Medicine and the National Institutes of Health.

Clinical Trials

As home to one of the world’s top cancer research centers, Memorial Sloan Kettering is typically involved in more than 900 clinical trials at a given time. Currently, clinical trials focused on the conditions I treat are enrolling new patients. If you’re interested in joining a clinical trial, click to learn about the trial’s purpose, eligibility criteria, and how to get more information.

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