I am a board-certified surgeon with clinical expertise diagnosing and treating breast cancer. In addition to my clinical practice, I am active in translational research and am the principal investigator of the William F. Keck Laboratory for Breast Cancer Research at Memorial Sloan Kettering.
The overriding goal of my laboratory research has been to develop a better understanding of the molecular genetics of breast cancer with a focus on the progression of high risk lesions such as lobular carcinoma in situ (LCIS). Previous data suggests that LCIS is a risk marker and does not become invasive cancer; however recent studies have reopened this debate. We hypothesize that molecular changes present in LCIS can be used to predict a woman’s risk of developing invasive breast cancer. We are testing this hypothesis using a variety of gene expression assays with the support of Memorial Sloan Kettering’s genomics core facility. This project is supported by the Geoffrey Beene Cancer Research Center and Susan G. Komen for the Cure.
In collaboration with Dr. Neal Rosen, members of my laboratory and I are also investigating the signaling pathways involved when ductal carcinoma in situ (DCIS) progresses to become invasive ductal cancer. We are focusing on the role of specific targets (including Her2-neu) in the Her2/PI3K pathway.
My clinical research focuses on the role of surgery in Stage IV breast cancer. I am the principal investigator of a multi-institutional study sponsored by the Translational Breast Cancer Research Consortium (TBCRC) designed to collect information regarding the use of surgery for the primary breast tumor in patients with metastatic disease.
- Clinical Expertise: Breast Cancer
- Languages Spoken: English
- Education: MD, University of Colorado Health Sciences Center
- Residencies: Ochsner Medical Institutions (New Orleans)
- Fellowships: Memorial Sloan Kettering Cancer Center
- Board Certifications: General Surgery
Atlas of Procedures in Breast Cancer Surgery. King TA, Borgen PI. London: Martin Dunitz; 2005.
“Surgery for the primary in patients with distant metastases.” King TA. In: Diseases of the Breast. 5th ed. Harris JR, Lippman ME, Morrow M, Osborne K, eds. Philadelphia: Lippincott, Williams, and Wilkins; 2013.
“Lobular carcinoma in situ: biology and management.” King TA, Reis-Filho JS. In: Diseases of the Breast. 5th ed. Harris JR, Lippman ME, Morrow M, Osborne K, eds. Philadelphia: Lippincott, Williams, and Wilkins; 2013.
“Breast disease.” King TA, Morrow M. In: Greenfield’s Surgery: Scientific Principles and Practice.5th ed. Mulholland MW, Lillemoe KD, Doherty GM, Maier RV, Upchurch GR, eds. Philadelphia: Lippincott, Williams and Wilkins; 2010.
“Cellular, biochemical and molecular targets in breast cancer.” King TA, Morrow M. In: Current Surgical Therapy. 10th ed. Cameron JL, Cameron AM, eds. New York: Mosby; 2010.
“Management of high risk breast lesions.” Andrade VP, King TA. In: Advanced Therapy of Breast Disease. 3rd ed. Esteva FJ, Skoracki RJ, Babiera GV, eds. Shelton, CT: People’s Medical Publishing House; 2010.
“Operative management.” King TA, Lucci AI. section eds. In: Textbook of Breast Surgical Oncology. Kuerer H, ed. New York: McGraw Hill; 2010.
“Principles of breast surgery.” McLaughlin SA, King TA. In: Principles and Practice of Cancer Rehabilitation. Stubblefield MD, O’Dell MW, Custodio CM, Fitzpatrick TW, eds. New York: Demos Medical; 2009.
“Surgery for the primary in patients with distant metastases.” King TA. In: Diseases of the Breast. 4th ed. Harris JR, Lippman ME, Morrow M, Osborne CK, eds. Philadelphia: Lippincott, Williams and Wilkins; 2009.
“Breast conservation: the role of lumpectomy in the surgical treatment of early invasive breast cancer.” King TA, Borgen PI. In: The Conservative Treatment of the Early Breast Cancer. Peltecu GC. Bucharest, Romania: BIC; 2003.
Research is integral to our mission at Memorial Sloan Kettering, and clinical trials help us discover better forms of patient care and treatment. For you, this could mean access to a new therapy or therapy combination. Click to see a list of the trials I’m currently leading.
Clinical Trials Led by Tari A. King
- A Phase III Study Evaluating of the Role of Axillary (Armpit) Lymph Node Removal in Patients with Breast Cancer with Positive Sentinel Lymph Nodes after Preoperative Chemotherapy
- A Study Assessing the Influence of Breast MRI Before Lumpectomy on Outcomes, Quality of Life, and Costs in Women with Breast Cancer