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Haelan

For Patients & Caregivers

How It Works Minus iconIcon indicating subtraction, or that the element can be closed. Plus IconIcon indicating addition, or that the element can be opened. Arrow (down) icon.An arrow icon, usually indicating that the containing element can be opened and closed.

Haelan has not been shown to treat or prevent cancer.

Haelan is a dietary supplement obtained by fermentation of soybeans. It contains compounds known as isoflavones that act like estrogen in the body and also have antioxidant activity. Laboratory studies have shown that these compounds slow down the growth of tumor cells. But recent studies indicate that isoflavones may also promote certain breast cancers.

Patients with estrogen receptor-positive breast cancers should avoid Haelan.

Purported Uses Minus iconIcon indicating subtraction, or that the element can be closed. Plus IconIcon indicating addition, or that the element can be opened. Arrow (down) icon.An arrow icon, usually indicating that the containing element can be opened and closed.
  • Cancer Treatment
    There are no data to support this use.
  • Allergy
    Data are lacking to support the role of Haelan in treating allergies.
  • Inflammation
    There is no scientific evidence to support this use.
  • AIDS
    This use is not backed by scientific evidence.
Do Not Take If Minus iconIcon indicating subtraction, or that the element can be closed. Plus IconIcon indicating addition, or that the element can be opened. Arrow (down) icon.An arrow icon, usually indicating that the containing element can be opened and closed.
  • You have hypersensitivity to soy products
  • You are taking tamoxifen for estrogen receptor-positive breast cancer (the isoflavones in Haelan may reduce the effects of tamoxifen)
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For Healthcare Professionals

Brand Name Minus iconIcon indicating subtraction, or that the element can be closed. Plus IconIcon indicating addition, or that the element can be opened. Arrow (down) icon.An arrow icon, usually indicating that the containing element can be opened and closed.
Haelan 951
Clinical Summary Minus iconIcon indicating subtraction, or that the element can be closed. Plus IconIcon indicating addition, or that the element can be opened. Arrow (down) icon.An arrow icon, usually indicating that the containing element can be opened and closed.

Haelan is a nutritional supplement derived by fermentation of soybeans. It is thought to have immunostimulatory effects and is being promoted to treat cancer, inflammation, AIDS, chronic fatigue syndrome, arthritis, and multiple sclerosis. Supporters claim that fermentation increases the bioavailability of isoflavones thereby potentiating their effects (1).

Several studies have shown that the isoflavones, genistein and daidzein, have antioxidant activity (2). They also exhibit antitumor effects in breast cancer, prostate cancer, sarcoma, and retinoblastoma cell lines (3) (4). However, some studies suggest that genistein has an antagonistic effect on tamoxifen and may actually promote the growth of tumor cells (5) (6). No data are available on Haelan’s antitumor effects in humans.

Purported Uses Minus iconIcon indicating subtraction, or that the element can be closed. Plus IconIcon indicating addition, or that the element can be opened. Arrow (down) icon.An arrow icon, usually indicating that the containing element can be opened and closed.
  • AIDS
  • Allergies
  • Cancer treatment
  • Inflammation
Mechanism of Action Minus iconIcon indicating subtraction, or that the element can be closed. Plus IconIcon indicating addition, or that the element can be opened. Arrow (down) icon.An arrow icon, usually indicating that the containing element can be opened and closed.

The exact mechanism of Haelan’s effects is unclear. Some studies have shown that isoflavones genistein and daidzein have antioxidant activity (2). They also exhibit antiproliferative effects in multiple cell lines including breast cancer, prostate cancer, neuroblastoma, sarcoma and retinoblastoma (3) (4). However, genistein also has an antagonistic effect on tamoxifen used to treat breast cancer (5) (6).

Contraindications Minus iconIcon indicating subtraction, or that the element can be closed. Plus IconIcon indicating addition, or that the element can be opened. Arrow (down) icon.An arrow icon, usually indicating that the containing element can be opened and closed.
  • Hypersensitivity to soy products
  • Patients with estrogen receptor-positive breast cancer
Herb-Drug Interactions Minus iconIcon indicating subtraction, or that the element can be closed. Plus IconIcon indicating addition, or that the element can be opened. Arrow (down) icon.An arrow icon, usually indicating that the containing element can be opened and closed.

Genistein, an isoflavone in Haelan may antagonize the effects of tamoxifen used for estrogen-dependent breast cancer (5) (6).

References Minus iconIcon indicating subtraction, or that the element can be closed. Plus IconIcon indicating addition, or that the element can be opened. Arrow (down) icon.An arrow icon, usually indicating that the containing element can be opened and closed.

  1. Product website. http://www.haelanproducts.com. Accessed October 24, 2012.

  2. Hasler CM, Finn SC. Soy: just a hill of beans? J Womens Health 1998;7:519-23.

  3. Sage D. Healing breast cancer with Haelan. Well Being Journal 1999;8(6).

  4. Nair V. and Hernandez V. Fermented soy: An aid to cancer prevention and therapy. Well being journal 2002:11(6).

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