Bevacizumab

Pediatric Medication

Brand Names: US

Avastin

Brand Names: Canada

Avastin

Warning

  • Very bad and sometimes deadly holes in the GI (gastrointestinal) tract or fistulas have happened with this drug. Talk with the doctor.
  • Very bad and sometimes deadly bleeding problems have happened with this drug. Talk with the doctor.
  • Do not give this drug if your child has very bad bleeding or if your child has recently coughed up blood.
  • This drug may affect how wounds heal. If your child needs to have surgery, you may need to stop giving this drug before surgery. Start giving it again after surgery as you have been told by the doctor. Talk with the doctor.

What is this drug used for?

  • It is used to treat cancer.
  • It may be given to your child for other reasons. Talk with the doctor.
  • This drug is not approved for use in children. However, the doctor may decide the benefits of taking this drug outweigh the risks. If your child has been given this drug, ask the doctor for information about the benefits and risks. Talk with the doctor if you have questions about giving this drug to your child.

What do I need to tell the doctor BEFORE my child takes this drug?

  • If your child has an allergy to this drug or any part of this drug.
  • If your child is allergic to any drugs like this one or any other drugs, foods, or other substances. Tell the doctor about the allergy and what signs your child had, like rash; hives; itching; shortness of breath; wheezing; cough; swelling of face, lips, tongue, or throat; or any other signs.
  • If this drug is being used to treat ovarian cancer and the cancer is also in certain parts of your child’s bowels or your child has bowel blockage.

If your child is breast-feeding a baby:

  • Be sure your child does not breast-feed a baby while taking this drug.
This is not a list of all drugs or health problems that interact with this drug.
Tell the doctor and pharmacist about all of your child’s drugs (prescription or OTC, natural products, vitamins) and health problems. You must check to make sure that it is safe for your child to take this drug with all of his/her drugs and health problems. Do not start, stop, or change the dose of any drug your child takes without checking with the doctor.

What are some things I need to know or do while my child takes this drug?

  • Tell all of your child’s health care providers that your child is taking this drug. This includes your child’s doctors, nurses, pharmacists, and dentists.
  • Your child may have more chance of getting an infection. Some infections have been deadly. Have your child wash hands often. Have your child stay away from people with infections, colds, or flu.
  • Your child may bleed more easily. Make sure your child is careful and avoids injury. Be sure your child has a soft toothbrush.
  • A very bad and sometimes deadly brain problem called posterior reversible encephalopathy syndrome (PRES) has happened with this drug. Talk with the doctor.
  • Blood clots have happened with this drug. Sometimes, blood clots like heart attack and stroke have been deadly. Talk with the doctor.
  • Call the doctor right away if your child has signs of a blood clot like chest pain or pressure; coughing up blood; shortness of breath; swelling, warmth, numbness, change of color, or pain in a leg or arm; or trouble speaking or swallowing.
  • If your child has an upset stomach or loose stools (diarrhea), is throwing up, or is not hungry, talk with the doctor. There may be ways to lower these side effects.
  • High blood pressure has happened with this drug. Have your child’s blood pressure checked as you have been told by the doctor.
  • Have your child’s blood work checked often. Talk with your child’s doctor.
  • Have your child’s urine checked as you have been told by the doctor.
  • Some patients have very bad side effects during the infusion. Tell your child’s doctor if your child has any bad effects during the infusion.
  • Talk with the doctor before your child gets any vaccines. Use with this drug may either raise the chance of very bad infection or make the vaccine not work as well.
  • This drug may cause your child to not be able to get pregnant later in life. Talk with the doctor.

If your child is or may be sexually active:

  • Have your child use birth control to prevent pregnancy while taking this drug and for 6 months after stopping this drug.

If your child is pregnant:

  • This drug may cause harm to the unborn baby if your child takes it during pregnancy.
  • If your child gets pregnant while taking this drug or within 6 months after her last dose, call the doctor right away.

What are some side effects that I need to call my child’s doctor about right away?

WARNING/CAUTION: Even though it may be rare, some people may have very bad and sometimes deadly side effects when taking a drug. Tell your child’s doctor or get medical help right away if your child has any of the following signs or symptoms that may be related to a very bad side effect:
  • Signs of an allergic reaction, like rash; hives; itching; red, swollen, blistered, or peeling skin with or without fever; wheezing; tightness in the chest or throat; trouble breathing or talking; unusual hoarseness; or swelling of the mouth, face, lips, tongue, or throat.
  • Signs of bleeding like throwing up blood or throw up that looks like coffee grounds; coughing up blood; blood in the urine; black, red, or tarry stools; bleeding from the gums; vaginal bleeding that is not normal; bruises without a reason or that get bigger; or any bleeding that is very bad or that you cannot stop.
  • Signs of infection like fever, chills, very bad sore throat, ear or sinus pain, cough, more sputum or change in color of sputum, pain with passing urine, mouth sores, or wound that will not heal.
  • Signs of high blood pressure like very bad headache or dizziness, passing out, or change in eyesight.
  • Weakness on 1 side of the body, trouble speaking or thinking, change in balance, drooping on one side of the face, or blurred eyesight.
  • Signs of high blood sugar like confusion, feeling sleepy, more thirst, more hungry, passing urine more often, flushing, fast breathing, or breath that smells like fruit.
  • Signs of electrolyte problems like mood changes, confusion, muscle pain or weakness, a heartbeat that does not feel normal, seizures, not hungry, or very bad upset stomach or throwing up.
  • A fast heartbeat.
  • Shortness of breath, a big weight gain, or swelling in the arms or legs.
  • Seizures.
  • Feeling confused.
  • Feeling less alert.
  • Loss of eyesight.
  • Very upset stomach or throwing up.
  • Very hard stools (constipation).
  • Very bad belly pain.
  • Skin wound that will not heal.
  • Mouth irritation or mouth sores.
  • Change in eyesight.
  • Sweating a lot.
  • Redness or irritation of the palms of hands or soles of feet.
  • Very bad and sometimes deadly kidney problems have happened with this drug. Call the doctor right away if your child is unable to pass urine, has blood in the urine, or has a change in the amount of urine passed.
  • A very bad skin problem (necrotizing fasciitis) has happened in people taking this drug. Sometimes, this has been deadly. Call the doctor right away if your child’s skin is warm with red or purple areas of swelling that spread quickly. Call the doctor right away if your child has ulcers, blisters, black spots on the skin, or any other skin changes that concern you.

What are some other side effects of this drug?

All drugs may cause side effects. However, many people have no side effects or only have minor side effects. Call your child’s doctor or get medical help if any of these side effects or any other side effects bother your child or do not go away:
  • Dizziness.
  • Headache.
  • Belly pain.
  • Back pain.
  • Muscle or joint pain.
  • Hard stools (constipation).
  • Loose stools (diarrhea).
  • Upset stomach or throwing up.
  • Feeling tired or weak.
  • Not hungry.
  • Hair loss.
  • Dry skin.
  • Change in nails.
  • Change in taste.
  • Weight loss.
  • Dry mouth.
  • Change in voice.
  • Runny nose.
  • Not able to sleep.
These are not all of the side effects that may occur. If you have questions about side effects, call your child’s doctor. Call your child’s doctor for medical advice about side effects.
You may report side effects to your national health agency.

How is this drug best given?

Give this drug as ordered by your child’s doctor. Read all information given to you. Follow all instructions closely.
  • It is given as an infusion into a vein over a period of time.

What do I do if my child misses a dose?

  • Call your child’s doctor to find out what to do.

How do I store and/or throw out this drug?

  • If you need to store this drug at home, talk with your child’s doctor, nurse, or pharmacist about how to store it.

General drug facts

  • If your child’s symptoms or health problems do not get better or if they become worse, call your child’s doctor.
  • Do not share your child’s drug with others and do not give anyone else’s drug to your child.
  • Keep a list of all your child’s drugs (prescription, natural products, vitamins, OTC) with you. Give this list to your child’s doctor.
  • Talk with your child’s doctor before giving your child any new drug, including prescription or OTC, natural products, or vitamins.
  • Keep all drugs in a safe place. Keep all drugs out of the reach of children and pets.
  • Check with your pharmacist about how to throw out unused drugs.
  • Some drugs may have another patient information leaflet. If you have any questions about this drug, please talk with your child’s doctor, nurse, pharmacist, or other health care provider.
  • If you think there has been an overdose, call your poison control center or get medical care right away. Be ready to tell or show what was taken, how much, and when it happened.

Consumer Information Use and Disclaimer

This information should not be used to decide whether or not to take this medicine or any other medicine. Only the healthcare provider has the knowledge and training to decide which medicines are right for a specific patient. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about this medicine. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to this medicine. This information is not specific medical advice and does not replace information you receive from the healthcare provider. You must talk with the healthcare provider for complete information about the risks and benefits of using this medicine.

Last Reviewed Date

2016-12-15

Copyright

© 2017 Wolters Kluwer Clinical Drug Information, Inc. and its affiliates and/or licensors. All rights reserved.

Last Updated