D.H.E. 45; Migranal
- Very bad and sometimes deadly poor blood flow to the hands, feet, or brain has happened when this drug was taken with certain other drugs like clarithromycin, erythromycin, indinavir, itraconazole, ketoconazole, nelfinavir, ritonavir, and troleandomycin. Do not take this drug if you are taking any of these drugs. There are many drugs that can do this. Check to make sure that it is safe for you to take this drug with all of your drugs.
- It is used to treat migraine headaches.
- It is used to treat cluster headaches.
- If you have an allergy to dihydroergotamine or any other part of this drug.
- If you are allergic to any drugs like this one, any other drugs, foods, or other substances. Tell your doctor about the allergy and what signs you had, like rash; hives; itching; shortness of breath; wheezing; cough; swelling of face, lips, tongue, or throat; or any other signs.
- If you have any of these health problems: High blood pressure or some types of migraine headaches like hemiplegic or basilar migraine.
- If you have any of these health problems: Blood vessel problems, chest pain or pressure, heart disease, kidney disease, liver disease, poor blood flow, very bad infection, or recent blood vessel surgery.
- If you have ever had a heart attack.
- If you have taken almotriptan, frovatriptan, naratriptan, rizatriptan, sumatriptan, or zolmitriptan in the last 24 hours.
- If you have taken ergotamine, methysergide, or any drug like them in the last 24 hours.
- If you are pregnant or may be pregnant. Do not take this drug if you are pregnant.
- If you are breast-feeding. Do not breast-feed while you take this drug.
- Tell all of your health care providers that you take this drug. This includes your doctors, nurses, pharmacists, and dentists.
- If you drink grapefruit juice or eat grapefruit often, talk with your doctor.
- Do not take more than what your doctor told you to take. Taking more than you are told may raise your chance of very bad side effects.
- If you smoke, talk with your doctor.
- Use care if you have risks for heart disease (high blood pressure, high cholesterol, overweight, high blood sugar or diabetes, cigarette smoking, man older than 40 years of age, other family members with early heart disease, woman after change of life). Talk with your doctor.
- Very bad and sometimes deadly side effects like a heartbeat that does not feel normal, heart attack, stroke, and very bad high blood pressure have happened with this drug. Talk with the doctor.
- Use birth control that you can trust to prevent pregnancy while taking this drug.
- This drug may cause harm to the unborn baby if you take it while you are pregnant. If you are pregnant or you get pregnant while taking this drug, call your doctor right away.
- Signs of an allergic reaction, like rash; hives; itching; red, swollen, blistered, or peeling skin with or without fever; wheezing; tightness in the chest or throat; trouble breathing or talking; unusual hoarseness; or swelling of the mouth, face, lips, tongue, or throat.
- Weakness on 1 side of the body, trouble speaking or thinking, change in balance, drooping on one side of the face, or blurred eyesight.
- Chest pain or pressure or a fast heartbeat.
- Numbness or tingling in the hands or feet.
- Very bad dizziness or passing out.
- Muscle pain or weakness.
- Muscle cramps.
- A heartbeat that does not feel normal.
- Change in color of hands or feet from pale to blue or red.
- Feeling cold.
- Fast or slow heartbeat.
- Very bad belly pain.
- Upset stomach or throwing up.
- Nose and throat irritation.
- Change in taste.
- Stuffy nose.
- Runny nose.
- It is given as a shot into a muscle, vein, or into the fatty part of the skin.
- Your doctor may teach you how to give the shot.
- Follow how to use carefully.
- Do not use if the solution is cloudy, leaking, or has particles.
- Do not use if solution changes color.
- Wash your hands before and after use.
- Throw away needles in a needle/sharp disposal box. Do not reuse needles or other items. When the box is full, follow all local rules for getting rid of it. Talk with a doctor or pharmacist if you have any questions.
- For breathing by the nose. Prime pump by squeezing it 4 times. Breathe in 1 spray in each nostril. Wait 15 minutes. Breathe in 1 more spray in each nostril.
- This drug is taken on an as needed basis. Do not take more often than told by the doctor.
- Store at room temperature. Do not refrigerate or freeze.
- Once the nose spray is ready, throw away any part of the opened ampul not used after 8 hours.
- Most of the time, this drug will be given in a hospital or doctor’s office. If stored at home, follow how to store as you were told by the doctor.
- Keep all drugs in a safe place. Keep all drugs out of the reach of children and pets.
- Check with your pharmacist about how to throw out unused drugs.
- If your symptoms or health problems do not get better or if they become worse, call your doctor.
- Do not share your drugs with others and do not take anyone else’s drugs.
- Keep a list of all your drugs (prescription, natural products, vitamins, OTC) with you. Give this list to your doctor.
- Talk with the doctor before starting any new drug, including prescription or OTC, natural products, or vitamins.
- Some drugs may have another patient information leaflet. If you have any questions about this drug, please talk with your doctor, nurse, pharmacist, or other health care provider.
- If you think there has been an overdose, call your poison control center or get medical care right away. Be ready to tell or show what was taken, how much, and when it happened.