Estrogens (Conjugated/Equine, Systemic)

Pediatric Medication

Brand Names: US

Premarin

Brand Names: Canada

C.E.S.®; Congest; PMS-Conjugated Estrogens C.S.D.; Premarin®

Warning

  • Estrogens may raise the chance of uterine cancer. Progestins may lower this chance. A warning sign for cancer of the uterus is vaginal bleeding. Report any vaginal bleeding to the doctor.
  • Do not use estrogens to prevent heart disease or dementia. Using estrogens may raise the chances of having a heart attack, a stroke, breast cancer, a blood clot, or dementia.
  • Use estrogens with or without progestin for the shortest time needed at the lowest useful dose.

What is this drug used for?

  • It is used to add estrogen to the body when the ovaries have been taken out or do not work the right way.
  • It may be given to your child for other reasons. Talk with the doctor.

Is it safe for my child to take this drug?

  • Not if your child has an allergy to estrogens, conjugated (equine), or any other part of this drug.
  • Be sure to let the doctor know if your child has any allergies or side effects to drugs, foods, or dyes. Make sure to tell about the allergy and what signs your child had. This includes telling about rash; hives; itching; shortness of breath; wheezing; cough; swelling of face, lips, tongue, or throat; or any other signs.
  • Not if your child has any of these health problems: Blood clotting problem, liver disease or vaginal bleeding.

What do I need to tell the doctor BEFORE my child takes this drug?

  • If your child has an allergy to this drug or any part of this drug.
  • If your child is allergic to any drugs like this one or any other drugs, foods, or other substances. Tell the doctor about the allergy and what signs your child had, like rash; hives; itching; shortness of breath; wheezing; cough; swelling of face, lips, tongue, or throat; or any other signs.
  • If your child has had any of these health problems: Bleeding disorder, blood clots, a higher risk of having a blood clot, breast cancer, liver disease, heart attack, stroke, tumor where estrogen makes it grow, or vaginal bleeding where the cause is not known.

If your child is pregnant:

  • Do not give this drug to your child if she is pregnant.
This is not a list of all drugs or health problems that interact with this drug.
Tell the doctor and pharmacist about all of your child’s drugs (prescription or OTC, natural products, vitamins) and health problems. You must check to make sure that it is safe for your child to take this drug with all of his/her drugs and health problems. Do not start, stop, or change the dose of any drug your child takes without checking with the doctor.

What are some things I need to know or do while my child takes this drug?

  • Tell dentists, surgeons, and other doctors that your child is using this drug.
  • If your child has high blood sugar (diabetes), you will need to watch his/her blood sugar closely.
  • Have your child’s blood pressure checked often. Talk with your child’s doctor.
  • Have your child’s blood work checked. Talk with your child’s doctor.
  • Your child may need to have a bone density test. Talk with the doctor.
  • Be sure that your child has regular breast exams and gynecology check-ups. The doctor will tell you how often your child needs to have these. Your child will also need to do breast self-exams as the doctor has told you. Talk with the doctor.
  • This drug may affect certain lab tests. Be sure the doctor and lab workers know your child takes this drug.
  • Alcohol may interact with this drug. Be sure your child does not drink alcohol.
  • Be sure your child does not smoke. Smoking raises the chance of heart disease. Talk with the doctor.
  • If your child drinks grapefruit juice or eats grapefruit often, talk with your child’s doctor.
  • If you or your child see parts of this drug in your child’s stool, call the doctor.
  • Talk with the doctor if your child will need to be still for long periods of time like long trips, bedrest after surgery, or illness. Not moving for long periods may raise the chance of blood clots.
  • This drug may affect growth in children and teens in some cases. They may need regular growth checks. Talk with the doctor.

If your child is breast-feeding a baby:

  • Tell the doctor if your child is breast-feeding a baby. You will need to talk about any risks to the baby.

What are some side effects that I need to call my child’s doctor about right away?

WARNING/CAUTION: Even though it may be rare, some people may have very bad and sometimes deadly side effects when taking a drug. Tell your child’s doctor or get medical help right away if your child has any of the following signs or symptoms that may be related to a very bad side effect:
  • Signs of an allergic reaction, like rash; hives; itching; red, swollen, blistered, or peeling skin with or without fever; wheezing; tightness in the chest or throat; trouble breathing or talking; unusual hoarseness; or swelling of the mouth, face, lips, tongue, or throat.
  • Signs of liver problems like dark urine, feeling tired, not hungry, upset stomach or stomach pain, light-colored stools, throwing up, or yellow skin or eyes.
  • Signs of a pancreas problem (pancreatitis) like very bad stomach pain, very bad back pain, or very bad upset stomach or throwing up.
  • Chest pain or pressure.
  • Shortness of breath.
  • Coughing up blood.
  • Change in strength on 1 side is greater than the other, trouble speaking or thinking, change in balance, or blurred eyesight.
  • Swelling, warmth, numbness, change of color, or pain in a leg or arm.
  • Very bad headache.
  • Very bad dizziness or passing out.
  • Very upset stomach or throwing up.
  • Pelvic pain.
  • Change in eyesight.
  • Bulging eyes.
  • Change in how contact lenses feel in the eyes.
  • A lump in the breast, breast soreness, or nipple discharge.
  • Breast pain.
  • Vaginal itching or discharge.
  • Vaginal bleeding that is not normal.
  • Low mood (depression).
  • Mood changes.
  • Memory problems or loss.
  • Swelling in hands or feet.

What are some other side effects of this drug?

All drugs may cause side effects. However, many people have no side effects or only have minor side effects. Call your child’s doctor or get medical help if any of these side effects or any other side effects bother your child or do not go away:

All products:

  • Headache.
  • Hair loss.
  • Enlarged breasts.
  • Breast soreness.
  • Leg cramps.
  • Swelling.
  • Cramps.
  • Bloating.
  • Upset stomach or throwing up.
  • Vaginal bleeding or spotting.
  • This drug may cause dark patches of skin on your child’s face. Avoid lots of sun, sunlamps, and tanning beds. Use sunscreen and dress your child in clothing and eyewear that protects him/her from the sun.

Shot:

  • Irritation where the shot is given.
These are not all of the side effects that may occur. If you have questions about side effects, call your child’s doctor. Call your child’s doctor for medical advice about side effects.
You may report side effects to your national health agency.

How is this drug best given?

Give this drug as ordered by your child’s doctor. Read all information given to you. Follow all instructions closely.

Tablet:

  • Give this drug at the same time of day.
  • Give this drug with or without food. Give with food if it causes an upset stomach.
  • There may be days when your child will not take this drug.

Shot:

  • It is given as a shot into a muscle or vein.

What do I do if my child misses a dose?

Tablet:

  • Give a missed dose as soon as you think about it.
  • If it is close to the time for your child’s next dose, skip the missed dose and go back to your child’s normal time.
  • Do not give 2 doses at the same time or extra doses.

Shot:

  • Call your child’s doctor to find out what to do.

How do I store and/or throw out this drug?

Tablet:

  • Store at room temperature.
  • Store in a dry place. Do not store in a bathroom.

Shot:

  • This drug will be given to your child in a hospital or doctor’s office. You will not store it at home.

All products:

  • Keep all drugs in a safe place. Keep all drugs out of the reach of children and pets.
  • Check with your pharmacist about how to throw out unused drugs.

General drug facts

  • If your child’s symptoms or health problems do not get better or if they become worse, call your child’s doctor.
  • Do not share your child’s drug with others and do not give anyone else’s drug to your child.
  • Keep a list of all your child’s drugs (prescription, natural products, vitamins, OTC) with you. Give this list to your child’s doctor.
  • Talk with your child’s doctor before giving your child any new drug, including prescription or OTC, natural products, or vitamins.
  • Some drugs may have another patient information leaflet. If you have any questions about this drug, please talk with your child’s doctor, pharmacist, or other health care provider.
  • If you think there has been an overdose, call your poison control center or get medical care right away. Be ready to tell or show what was taken, how much, and when it happened.

Consumer Information Use and Disclaimer

This information should not be used to decide whether or not to take this medicine or any other medicine. Only the healthcare provider has the knowledge and training to decide which medicines are right for a specific patient. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about this medicine. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to this medicine. This information is not specific medical advice and does not replace information you receive from the healthcare provider. You must talk with the healthcare provider for complete information about the risks and benefits of using this medicine.

Last Reviewed Date

2015-03-18

Copyright

© 2015 Wolters Kluwer Clinical Drug Information, Inc. and its affiliates and/or licensors. All rights reserved.
If you have any questions or concerns, talk with a member of your healthcare team. You can reach them Monday through Friday from 9:00 am to 5:00 pm at ____________________. After 5:00 pm, during the weekend, and on holidays, please call____________________. If there’s no number listed, or you’re not sure, call 212-639-2000.
Estrogens (Conjugated/Equine, Systemic)
©2015 Memorial Sloan Kettering Cancer Center - Generated on September 4, 2015