Everolimus

Pediatric Medication

Brand Names: US

Afinitor; Afinitor Disperz; Zortress

Brand Names: Canada

Afinitor

Warning

Zortress®

  • This drug may raise the chance of very bad and sometimes deadly infections. Talk with the doctor.
  • This drug may raise the chance of getting cancer like lymphoma or skin cancer. Talk with the doctor.
  • In people who have had a kidney transplant, the risk of a blood clot in the kidney transplant may be raised. This may lead to loss of the kidney. Most of the time, this has happened within the first 30 days after the kidney transplant. Call the doctor right away if your child has back, groin, or belly pain; is not able to pass urine; has blood in the urine, dark urine, a fever, or an upset stomach; or is throwing up.
  • If your child is taking this drug with cyclosporine, your child will need a lower dose of cyclosporine. Talk with the doctor.
  • This drug is not to be used if your child has had a heart transplant. More deaths were seen in people taking this drug after a heart transplant. Talk with the doctor.

What is this drug used for?

  • It is used to treat cancer.
  • It is used to treat certain kinds of kidney cysts.
  • It is used to keep the body from harming the organ after an organ transplant.
  • It may be given to your child for other reasons. Talk with the doctor.

What do I need to tell the doctor BEFORE my child takes this drug?

All products:

  • If your child has an allergy to this drug or any part of this drug.
  • If your child is allergic to any drugs like this one or any other drugs, foods, or other substances. Tell the doctor about the allergy and what signs your child had, like rash; hives; itching; shortness of breath; wheezing; cough; swelling of face, lips, tongue, or throat; or any other signs.
  • If your child has an infection.
  • If your child is taking any drugs (prescription or OTC, natural products, vitamins) that must not be taken with this drug, like certain drugs that are used for HIV, infections, or depression. There are many drugs that must not be taken with this drug.
  • If your child is taking another drug that has the same drug in it.
  • Do not give St. John’s wort with this drug. This drug may not work as well.

Zortress®

  • If your child has a rare hereditary problem of galactose intolerance, Lapp lactase deficiency, or glucose-galactose malabsorption.
This is not a list of all drugs or health problems that interact with this drug.
Tell the doctor and pharmacist about all of your child’s drugs (prescription or OTC, natural products, vitamins) and health problems. You must check to make sure that it is safe for your child to take this drug with all of his/her drugs and health problems. Do not start, stop, or change the dose of any drug your child takes without checking with the doctor.

What are some things I need to know or do while my child takes this drug?

All products:

  • Tell dentists, surgeons, and other doctors that your child is using this drug.
  • Your child may have more chance of getting infections. Avoid crowds and people with infections, colds, or flu.
  • This drug may raise the chance of very bad and sometimes deadly infections. Talk with the doctor.
  • If your child has high blood sugar (diabetes), you will need to watch his/her blood sugar closely.
  • Have your child’s blood work checked often. Talk with your child’s doctor.
  • Avoid giving your child grapefruit and grapefruit juice.
  • Talk with the doctor before your child gets any vaccines. Use with this drug may either raise the chance of very bad infection or make the vaccine not work as well.
  • If your child has mouth irritation or mouth sores, do not give your child mouth rinses that have alcohol, peroxide, iodine, or thyme in them. Talk with the doctor.

If your child is or may be sexually active:

  • Have your child use birth control to prevent pregnancy while taking this drug and for 2 months after stopping this drug.

If your child is pregnant or breast-feeding a baby:

  • This drug may cause harm to the unborn baby if your child takes it during pregnancy.
  • Talk with the doctor if your child is pregnant, becomes pregnant, or is breast-feeding a baby. You will need to talk about the benefits and risks of using this drug.

Zortress®

  • There is a chance of skin cancer. Have your child avoid lots of sun, sunlamps, and tanning beds. Use sunscreen and dress your child in clothing and eyewear that protects your child from the sun.
  • In people who have had a liver transplant, the risk of a blood clot in the liver transplant may be raised. This may lead to loss of the liver or death. Most of the time, this has happened within the first 30 days after the liver transplant. Talk with the doctor.
  • This drug may affect sperm in males. This may affect being able to father a child later in life. Talk with the doctor.

All other products:

  • Make sure your child avoids being near anyone who has had a recent live vaccine. There are many types of live vaccines. Ask your doctor or pharmacist if you are not sure.
  • This drug may cause fertility problems. This may affect being able to have children later in life. Talk with the doctor.

What are some side effects that I need to call my child’s doctor about right away?

WARNING/CAUTION: Even though it may be rare, some people may have very bad and sometimes deadly side effects when taking a drug. Tell your child’s doctor or get medical help right away if your child has any of the following signs or symptoms that may be related to a very bad side effect:

All products:

  • Signs of an allergic reaction, like rash; hives; itching; red, swollen, blistered, or peeling skin with or without fever; wheezing; tightness in the chest or throat; trouble breathing or talking; unusual hoarseness; or swelling of the mouth, face, lips, tongue, or throat.
  • Signs of infection like fever, chills, very bad sore throat, ear or sinus pain, cough, more sputum or change in color of sputum, pain with passing urine, mouth sores, or wound that will not heal.
  • Signs of high blood sugar like confusion, feeling sleepy, more thirst, more hungry, passing urine more often, flushing, fast breathing, or breath that smells like fruit.
  • Signs of liver problems like dark urine, feeling tired, not hungry, upset stomach or stomach pain, light-colored stools, throwing up, or yellow skin or eyes.
  • Redness or irritation of the palms of hands or soles of feet.
  • A burning, numbness, or tingling feeling that is not normal.
  • Chest pain or pressure or a fast heartbeat.
  • Any bruising or bleeding.
  • Very bad mouth irritation.
  • A heartbeat that does not feel normal.
  • Seizures.
  • Very bad dizziness or passing out.
  • Very bad headache.
  • Feeling very tired or weak.
  • Muscle pain or weakness.
  • Period (menstrual) changes. These may include a missed period.
  • Mood changes.
  • Change in the way your child acts.
  • Swelling.
  • This drug may affect how wounds heal. Sometimes, people with wound healing problems have needed surgery. Call the doctor right away if your child has a wound that is red, warm, painful, or swollen. Call the doctor right away if your child has a wound that opens up or if there is blood, fluid, or pus in a wound.
  • Very bad and sometimes deadly lung problems have happened with this drug. Call the doctor right away if your child has lung or breathing problems like trouble breathing, shortness of breath, or a cough that is new or worse.
  • Very bad and sometimes deadly kidney problems have happened with this drug. Call the doctor right away if your child is unable to pass urine, has blood in the urine, or has a change in the amount of urine passed.

Zortress®

  • Change in color or size of a mole.
  • A skin lump or growth.
  • Swollen gland.
  • Night sweats.
  • A big weight loss.
  • Some people treated with this drug have had very bad kidney problems caused by a certain viral infection (BK virus). In people who have had a kidney transplant, BK virus infection may cause loss of the kidney. Call the doctor right away if your child has signs of kidney problems like change in the amount of urine passed, trouble passing urine, pain when passing urine, or blood in the urine.
  • A very bad brain problem called progressive multifocal leukoencephalopathy (PML) may happen with this drug. It may cause disability or death. Tell the doctor right away if your child has signs like confusion, memory problems, low mood (depression), change in the way your child acts, change in strength on 1 side is greater than the other, trouble speaking or thinking, change in balance, or change in eyesight.

What are some other side effects of this drug?

All drugs may cause side effects. However, many people have no side effects or only have minor side effects. Call your child’s doctor or get medical help if any of these side effects or any other side effects bother your child or do not go away:
  • Dizziness.
  • Feeling tired or weak.
  • Headache.
  • Not able to sleep.
  • Pimples (acne).
  • Dry skin.
  • Upset stomach or throwing up.
  • Loose stools (diarrhea).
  • Hard stools (constipation).
  • Mouth irritation or mouth sores.
  • Change in taste.
  • Not hungry.
  • Weight loss.
  • Dry mouth.
  • Change in nails.
  • Hair loss.
  • Joint pain.
  • Back pain.
  • Pain in arms or legs.
  • Muscle spasm.
  • Nosebleed.
  • Belly pain.
These are not all of the side effects that may occur. If you have questions about side effects, call your child’s doctor. Call your child’s doctor for medical advice about side effects.
You may report side effects to your national health agency.

How is this drug best given?

Give this drug as ordered by your child’s doctor. Read all information given to you. Follow all instructions closely.

All products:

  • To gain the most benefit, do not miss giving your child doses.
  • Give as you have been told, even if your child feels well.
  • Give this drug at the same time of day.
  • Give this drug with or without food. Always give with food or always give on an empty stomach.

Tablet:

  • Give this drug with a full glass of water.
  • Have your child swallow whole. Do not let your child chew, break, or crush.

Zortress®

  • If you take cyclosporine or tacrolimus, take them at the same time as this drug.

Disperz tablets:

  • Give as a liquid only. Do not let your child swallow tablets whole.
  • Wear gloves when touching this drug.
  • Mix with water as you have been told before drinking.
  • Have your child drink right after mixing. Throw away any part not used after 1 hour.
  • If possible, do not mix this drug if you are pregnant or plan to get pregnant. Talk with the doctor.

What do I do if my child misses a dose?

Zortress®

  • Give a missed dose as soon as you think about it.
  • If it is close to the time for your child’s next dose, skip the missed dose and go back to your child’s normal time.

All other products:

  • Give a missed dose as soon as you think about it.
  • If it has been 6 hours or more since the missed dose, skip the missed dose and go back to your child’s normal time.

All products:

  • Do not give 2 doses at the same time or extra doses.

How do I store and/or throw out this drug?

  • Store in the original container at room temperature.
  • Protect from light.
  • Store in a dry place. Do not store in a bathroom.
  • Keep all drugs out of the reach of children and pets.
  • Check with your pharmacist about how to throw out unused drugs.

General drug facts

  • If your child’s symptoms or health problems do not get better or if they become worse, call your child’s doctor.
  • Do not share your child’s drug with others and do not give anyone else’s drug to your child.
  • Keep a list of all your child’s drugs (prescription, natural products, vitamins, OTC) with you. Give this list to your child’s doctor.
  • Talk with your child’s doctor before giving your child any new drug, including prescription or OTC, natural products, or vitamins.
  • Some drugs may have another patient information leaflet. If you have any questions about this drug, please talk with your child’s doctor, pharmacist, or other health care provider.
  • If you think there has been an overdose, call your poison control center or get medical care right away. Be ready to tell or show what was taken, how much, and when it happened.

Consumer Information Use and Disclaimer

This information should not be used to decide whether or not to take this medicine or any other medicine. Only the healthcare provider has the knowledge and training to decide which medicines are right for a specific patient. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about this medicine. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to this medicine. This information is not specific medical advice and does not replace information you receive from the healthcare provider. You must talk with the healthcare provider for complete information about the risks and benefits of using this medicine.

Last Reviewed Date

2015-06-10

Copyright

© 2015 Wolters Kluwer Clinical Drug Information, Inc. and its affiliates and/or licensors. All rights reserved.
If you have any questions or concerns, talk with a member of your healthcare team. You can reach them Monday through Friday from 9:00 am to 5:00 pm at ____________________. After 5:00 pm, during the weekend, and on holidays, please call____________________. If there’s no number listed, or you’re not sure, call 212-639-2000.
Everolimus
©2015 Memorial Sloan Kettering Cancer Center - Generated on July 31, 2015