Fludara; Fludarabine Phosphate for Injection; Fludarabine Phosphate for Injection, USP; Fludarabine Phosphate Injection, PPC STD.
- This drug may have unsafe effects on the bone marrow. The bone marrow may not be able to make cells found in the blood as well as it used to.
- This drug may sometimes cause deadly autoimmune diseases. Talk with the doctor.
- This drug may cause very bad and sometimes deadly nervous system problems. These include loss of eyesight, confusion, and seizures. Sometimes, people have fallen into a coma. Talk with the doctor.
- Have blood work checked as you have been told by the doctor. Talk with the doctor.
- Do not take this drug with pentostatin. Very bad and sometimes deadly lung problems may happen. Talk with the doctor.
- It is used to treat a type of leukemia.
- It may be given to your child for other reasons. Talk with the doctor.
- If your child has an allergy to this drug or any part of this drug.
- If your child is allergic to any drugs like this one or any other drugs, foods, or other substances. Tell the doctor about the allergy and what signs your child had, like rash; hives; itching; shortness of breath; wheezing; cough; swelling of face, lips, tongue, or throat; or any other signs.
- If your child has kidney disease.
- If your child has a type of anemia called hemolytic anemia.
If your child is breast-feeding a baby:
- Talk with the doctor if your child is breast-feeding a baby or plans to breast-feed a baby.
- Tell all of your child’s health care providers that your child is taking this drug. This includes your child’s doctors, nurses, pharmacists, and dentists.
- Have your child avoid tasks or actions that call for alertness or clear eyesight until you see how this drug affects your child. These are things like riding a bike, playing sports, or using items such as scissors, lawnmowers, electric scooters, toy cars, or motorized vehicles.
- Skin cancer has happened during or after treatment with this drug. Talk with the doctor.
- Your child may have more chance of getting infections. Have your child wash hands often. Avoid crowds and people with infections, colds, or flu.
- Your child may bleed more easily. Make sure your child is careful and avoids injury. Be sure your child has a soft toothbrush.
- Talk with the doctor before your child gets any vaccines while taking this drug and after your child stops taking it. Vaccine use with this drug may either raise the chance of an infection or make the vaccine not work as well. Talk with the doctor.
- If your child has taken this drug and is getting a blood transfusion, talk with your child’s doctor.
- This drug may affect sperm in males. This may affect being able to father a child later in life. Talk with the doctor.
If your child is or may be sexually active:
- Have your child use birth control to prevent pregnancy during care and for some time after care ends. Talk with the doctor to see how long your child needs to use birth control after stopping this drug.
- If your child is a male and has sex with a female who could get pregnant, they must prevent pregnancy during care and for some time after care ends. Talk with the doctor to see how long they must use birth control after your child stops this drug.
- If your child is a male and his sex partner gets pregnant while he takes this drug or within several months after his last dose, call the doctor right away.
If your child is pregnant:
- This drug may cause harm to the unborn baby if your child takes it during pregnancy.
- If your child gets pregnant while taking this drug or within several months after her last dose, call the doctor right away.
- Signs of an allergic reaction, like rash; hives; itching; red, swollen, blistered, or peeling skin with or without fever; wheezing; tightness in the chest or throat; trouble breathing, swallowing, or talking; unusual hoarseness; or swelling of the mouth, face, lips, tongue, or throat.
- Signs of infection like fever, chills, very bad sore throat, ear or sinus pain, cough, more sputum or change in color of sputum, pain with passing urine, mouth sores, or wound that will not heal.
- Signs of bleeding like throwing up blood or throw up that looks like coffee grounds; coughing up blood; blood in the urine; black, red, or tarry stools; bleeding from the gums; vaginal bleeding that is not normal; bruises without a reason or that get bigger; or any bleeding that is very bad or that you cannot stop.
- Feeling very tired or weak.
- Dark urine or yellow skin or eyes.
- Not able to pass urine.
- Shortness of breath.
- Chest pain or pressure.
- Change in eyesight.
- Feeling agitated.
- A burning, numbness, or tingling feeling that is not normal.
- Not able to eat.
- A skin lump or growth.
- Change in color or size of a mole.
- Swelling in the arms or legs.
- Patients with cancer who take this drug may be at greater risk of getting a bad and sometimes deadly health problem called tumor lysis syndrome (TLS). Call your child’s doctor right away if your child has a fast heartbeat; a heartbeat that does not feel normal; any passing out; trouble passing urine; muscle weakness or cramps; upset stomach, throwing up, loose stools, or not able to eat; or feel sluggish.
- A very bad brain problem called progressive multifocal leukoencephalopathy (PML) may happen with this drug. It may cause disability or death. Tell the doctor right away if your child has signs like confusion, memory problems, low mood (depression), change in the way your child acts, change in strength on 1 side is greater than the other, trouble speaking or thinking, change in balance, or change in eyesight.
- A very bad skin reaction (Stevens-Johnson syndrome/toxic epidermal necrolysis) may happen. It can cause very bad health problems that may not go away, and sometimes death. Get medical help right away if your child has signs like red, swollen, blistered, or peeling skin (with or without fever); red or irritated eyes; or sores in the mouth, throat, nose, or eyes.
- Feeling tired or weak.
- Upset stomach or throwing up.
- Mouth irritation or mouth sores.
- Not hungry.
- Loose stools (diarrhea).
- Muscle pain.
- Give this drug with or without food.
- Have your child swallow whole. Do not let your child chew, break, or crush.
- Give this drug with a full glass of water.
- Talk with the doctor to find out what to do if your child throws up after taking a dose of this drug.
- It is given as an infusion into a vein over a period of time.
- This drug is not given every day. Be sure you know how to give it. Talk with the doctor if you have questions.
- If your child has an upset stomach or loose stools (diarrhea), is throwing up, or is not hungry, talk with the doctor. There may be ways to lower these side effects.
- Call your child’s doctor to find out what to do.
- Store in the original container at room temperature.
- Do not freeze.
- If you need to store this drug at home, talk with your child’s doctor, nurse, or pharmacist about how to store it.
- Keep all drugs in a safe place. Keep all drugs out of the reach of children and pets.
- Throw away unused or expired drugs. Do not flush down a toilet or pour down a drain unless you are told to do so. Check with your pharmacist if you have questions about the best way to throw out drugs. There may be drug take-back programs in your area.
- If your child’s symptoms or health problems do not get better or if they become worse, call your child’s doctor.
- Do not share your child’s drug with others and do not give anyone else’s drug to your child.
- Keep a list of all your child’s drugs (prescription, natural products, vitamins, OTC) with you. Give this list to your child’s doctor.
- Talk with your child’s doctor before giving your child any new drug, including prescription or OTC, natural products, or vitamins.
- Some drugs may have another patient information leaflet. If you have any questions about this drug, please talk with your child’s doctor, nurse, pharmacist, or other health care provider.
- If you think there has been an overdose, call your poison control center or get medical care right away. Be ready to tell or show what was taken, how much, and when it happened.