This information from Lexicomp® explains what you need to know about this medication, including what it’s used for, how to take it, its side effects, and when to call your healthcare provider.
- This drug may lower the ability of the bone marrow to make blood cells that the body needs. This can lead to needing a blood transfusion and very bad and sometimes deadly bleeding problems or infections. Tell the doctor right away if your child has signs of infection like fever, chills, or sore throat; any bruising or bleeding; or if your child feels very tired or weak.
- Your child will need blood work checked before starting this drug and during treatment. Talk with the doctor.
- This drug may cause very bad and sometimes deadly nervous system problems. These include brain problems, hallucinations, and confusion. Sometimes, people have fallen into a coma. Nervous system problems may start within a few hours after getting this drug and may last for 2 to 3 days after stopping it. Talk with the doctor.
- Kidney problems like kidney failure have happened with this drug. Tell your child’s doctor if your child has ever had kidney problems.
- This drug may cause blood in the urine and bladder pain. Talk with the doctor.
- It is used to treat testicular cancer.
- It may be given to your child for other reasons. Talk with the doctor.
- If your child is allergic to this drug; any part of this drug; or any other drugs, foods, or substances. Tell the doctor about the allergy and what signs your child had.
- If your child has a low platelet count or a low white blood cell count.
- If your child has trouble passing urine.
If your child is breast-feeding a baby:
- Talk with the doctor if your child is breast-feeding a baby or plans to breast-feed a baby.
This is not a list of all drugs or health problems that interact with this drug.
Tell the doctor and pharmacist about all of your child’s drugs (prescription or OTC, natural products, vitamins) and health problems. You must check to make sure that it is safe for your child to take this drug with all of his/her drugs and health problems. Do not start, stop, or change the dose of any drug your child takes without checking with the doctor.
- Tell all of your child’s health care providers that your child is taking this drug. This includes your child’s doctors, nurses, pharmacists, and dentists.
- Talk with the doctor before your child gets any vaccines. Use of some vaccines with this drug may either raise the chance of very bad infection or make the vaccine not work as well.
- Have your child avoid tasks or actions that call for alertness until you see how this drug affects your child. These are things like riding a bike, playing sports, or using items such as scissors, lawnmowers, electric scooters, toy cars, or motorized vehicles.
- Your child may bleed more easily. Make sure your child is careful and avoids injury. Be sure your child has a soft toothbrush.
- Your child may have more chance of getting infections. Have your child wash hands often. Avoid crowds and people with infections, colds, or flu.
- Have blood work checked as you have been told by the doctor. Talk with the doctor.
- Have your child’s urine checked as you have been told by the doctor.
- If your child has an upset stomach or diarrhea, is throwing up, or is not hungry, talk with the doctor. There may be ways to lower these side effects.
- Alcohol may interact with this drug. Be sure your child does not drink alcohol.
- Talk with the doctor before giving your child other drugs and natural products that may slow your child’s actions.
- Other types of cancer may rarely happen later in life.
- Females treated with this drug may go through menopause at a younger age than normal. Talk with the doctor.
- This drug may cause your child to not be able to get pregnant later in life. Talk with the doctor.
- This drug may affect sperm in males. This may affect being able to father a child later in life. Talk with the doctor.
If your child has menstrual periods:
- Periods may stop in females treated with this drug. This may not go back to normal. Females treated with this drug may go through menopause at a younger age than normal. Talk with your child’s doctor.
If your child is or may be sexually active:
- Have your child use birth control to prevent pregnancy while taking this drug. Your child may also need to use birth control for some time after the last dose. Talk with your child’s doctor to see if your child needs to use birth control after she stops this drug.
- If your child is a male and has sex with a female who could get pregnant, they must prevent pregnancy during treatement and for 6 months after his last dose.
- If your child is a male and his sex partner gets pregnant while he takes this drug or within 6 months after his last dose, call the doctor right away.
If your child is pregnant:
- This drug may cause harm to the unborn baby if your child takes it during pregnancy.
- If your child gets pregnant while taking this drug or within several months after her last dose, call the doctor right away.
WARNING/CAUTION: Even though it may be rare, some people may have very bad and sometimes deadly side effects when taking a drug. Tell your child’s doctor or get medical help right away if your child has any of the following signs or symptoms that may be related to a very bad side effect:
- Signs of an allergic reaction, like rash; hives; itching; red, swollen, blistered, or peeling skin with or without fever; wheezing; tightness in the chest or throat; trouble breathing, swallowing, or talking; unusual hoarseness; or swelling of the mouth, face, lips, tongue, or throat.
- Signs of infection like fever, chills, very bad sore throat, ear or sinus pain, cough, more sputum or change in color of sputum, pain with passing urine, mouth sores, or wound that will not heal.
- Signs of bleeding like throwing up or coughing up blood; vomit that looks like coffee grounds; blood in the urine; black, red, or tarry stools; bleeding from the gums; abnormal vaginal bleeding; bruises without a cause or that get bigger; or bleeding you cannot stop.
- Signs of kidney problems like unable to pass urine, change in how much urine is passed, blood in the urine, or a big weight gain.
- Feeling confused.
- Feeling very tired or weak.
- Feeling sleepy.
- Dizziness or passing out.
- Hallucinations (seeing or hearing things that are not there).
- Change in eyesight, eye pain, or very bad eye irritation.
- Change in the way your child acts.
- Trouble controlling body movements, twitching, change in balance, trouble swallowing or speaking.
- Not able to control passing urine.
- A burning, numbness, or tingling feeling that is not normal.
- Skin wound that will not heal.
- Hearing loss.
- Ringing in ears.
- Heart problems like heart failure and certain very bad abnormal heartbeats have happened with this drug. Sometimes, these heart problems have been deadly. Call your child’s doctor right away if your child has a fast or abnormal heartbeat; very bad dizziness or passing out; or shortness of breath, a big weight gain, or swelling in the arms or legs.
- Very bad and sometimes deadly liver problems have happened with this drug. Call your child’s doctor right away if your child has signs of liver problems like dark urine, feeling tired, not hungry, upset stomach or stomach pain, light-colored stools, throwing up, or yellow skin or eyes.
- Some people have had lung problems with this drug. Sometimes, this has been deadly. Call your child’s doctor right away if your child has signs of lung problems like shortness of breath or other trouble breathing, cough that is new or worse, or fever.
All drugs may cause side effects. However, many people have no side effects or only have minor side effects. Call your child’s doctor or get medical help if any of these side effects or any other side effects bother your child or do not go away:
- Upset stomach or throwing up.
- Hair loss.
These are not all of the side effects that may occur. If you have questions about side effects, call your child’s doctor. Call your child’s doctor for medical advice about side effects.
You may report side effects to your national health agency.
Give this drug as ordered by your child’s doctor. Read all information given to you. Follow all instructions closely.
- It is given as an infusion into a vein over a period of time.
- Have your child pass urine often. Your child needs to empty his/her bladder often. Having your child drink lots of liquids will help.
- Have your child drink lots of noncaffeine liquids every day unless told to drink less liquid by your child’s doctor.
- If your child drinks grapefruit juice or eats grapefruit often, talk with your child’s doctor.
- To help with mouth sores, have your child use a soft toothbrush or cotton swabs and rinse the mouth. Do not let your child use mouth rinses that have alcohol in them.
- Call your child’s doctor to find out what to do.
- If you need to store this drug at home, talk with your child’s doctor, nurse, or pharmacist about how to store it.
- If your child’s symptoms or health problems do not get better or if they become worse, call your child’s doctor.
- Do not share your child’s drug with others and do not give anyone else’s drug to your child.
- Keep all drugs in a safe place. Keep all drugs out of the reach of children and pets.
- Throw away unused or expired drugs. Do not flush down a toilet or pour down a drain unless you are told to do so. Check with your pharmacist if you have questions about the best way to throw out drugs. There may be drug take-back programs in your area.
- Some drugs may have another patient information leaflet. If you have any questions about this drug, please talk with your child’s doctor, nurse, pharmacist, or other health care provider.
- If you think there has been an overdose, call your poison control center or get medical care right away. Be ready to tell or show what was taken, how much, and when it happened.
This information should not be used to decide whether or not to take this medicine or any other medicine. Only the healthcare provider has the knowledge and training to decide which medicines are right for a specific patient. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about this medicine. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to this medicine. This information is not specific medical advice and does not replace information you receive from the healthcare provider. You must talk with the healthcare provider for complete information about the risks and benefits of using this medicine.
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