Ifosfamide

Pediatric Medication

Brand Names: US

Ifex

Brand Names: Canada

Ifex; Ifosfamide for Injection

Warning

  • This drug may lower the ability of the bone marrow to make blood cells that the body needs. This can lead to needing a blood transfusion and very bad and sometimes deadly bleeding problems or infections. Tell the doctor right away if your child has signs of infection like fever, chills, or sore throat; any bruising or bleeding; or if your child feels very tired or weak.
  • Have your child’s blood work checked often. Talk with your child’s doctor.
  • This drug may cause blood in the urine and bladder pain. Talk with the doctor.
  • This drug may cause kidney problems in some patients. Talk with the doctor.
  • This drug may cause very bad and sometimes deadly nervous system problems. These include brain problems, hallucinations, and confusion. Sometimes, people have fallen into a coma. Nervous system problems may start within a few hours after getting this drug and may last for 2 to 3 days after stopping it. Talk with the doctor.
  • Your child will be closely watched by the doctor.

What is this drug used for?

  • It is used to treat testicular cancer.
  • It may be given to your child for other reasons. Talk with the doctor.

What do I need to tell the doctor BEFORE my child takes this drug?

  • If your child has an allergy to this drug or any part of this drug.
  • If your child is allergic to any drugs like this one or any other drugs, foods, or other substances. Tell the doctor about the allergy and what signs your child had, like rash; hives; itching; shortness of breath; wheezing; cough; swelling of face, lips, tongue, or throat; or any other signs.
  • If your child is not able to pass urine.

If your child is breast-feeding a baby:

  • Talk with the doctor if your child is breast-feeding a baby or plans to breast-feed a baby.
This is not a list of all drugs or health problems that interact with this drug.
Tell the doctor and pharmacist about all of your child’s drugs (prescription or OTC, natural products, vitamins) and health problems. You must check to make sure that it is safe for your child to take this drug with all of his/her drugs and health problems. Do not start, stop, or change the dose of any drug your child takes without checking with the doctor.

What are some things I need to know or do while my child takes this drug?

  • Tell all of your child’s health care providers that your child is taking this drug. This includes your child’s doctors, nurses, pharmacists, and dentists.
  • Talk with the doctor before your child gets any vaccines. Use with this drug may either raise the chance of very bad infection or make the vaccine not work as well.
  • Very bad and sometimes deadly allergic reactions have rarely happened. Talk with your child’s doctor.
  • Have your child avoid tasks or actions that call for alertness until you see how this drug affects your child. These are things like riding a bike, playing sports, or using items such as scissors, lawnmowers, electric scooters, toy cars, or motorized vehicles.
  • Your child may bleed more easily. Make sure your child is careful and avoids injury. Be sure your child has a soft toothbrush.
  • Your child may have more chance of getting infections. Avoid crowds and people with infections, colds, or flu.
  • Have your child’s urine checked as you have been told by the doctor.
  • If your child has an upset stomach or loose stools (diarrhea), is throwing up, or is not hungry, talk with the doctor. There may be ways to lower these side effects.
  • Alcohol may interact with this drug. Be sure your child does not drink alcohol.
  • Talk with the doctor before giving your child other drugs and natural products that may slow your child’s actions.
  • This drug may raise the chance of a very bad and sometimes deadly heart problem. Talk with the doctor.
  • Other types of cancer may rarely happen later in life.
  • Very bad and sometimes deadly lung problems have happened with this drug. Call the doctor right away if your child has lung or breathing problems like trouble breathing, shortness of breath, or a cough that is new or worse.
  • Females treated with this drug may go through menopause at a younger age than normal. Talk with the doctor.
  • This drug may cause your child to not be able to get pregnant later in life. Talk with the doctor.
  • This drug may affect sperm in males. This may affect being able to father a child later in life. Talk with the doctor.

If your child has menstrual periods:

  • Periods may stop in females treated with this drug. This may not go back to normal. Talk with the doctor.

If your child is or may be sexually active:

  • Have your child use birth control to prevent pregnancy while taking this drug.
  • If your child is a male and has sex with a female who could get pregnant, they must prevent pregnancy during care and for 6 months after care ends. They must use birth control that can be trusted.
  • If your child is a male and his sex partner gets pregnant while he takes this drug or within 6 months after his last dose, call the doctor right away.

If your child is pregnant:

  • This drug may cause harm to the unborn baby if your child takes it during pregnancy. If your child is pregnant or gets pregnant while taking this drug, call the doctor right away.

What are some side effects that I need to call my child’s doctor about right away?

WARNING/CAUTION: Even though it may be rare, some people may have very bad and sometimes deadly side effects when taking a drug. Tell your child’s doctor or get medical help right away if your child has any of the following signs or symptoms that may be related to a very bad side effect:
  • Signs of an allergic reaction, like rash; hives; itching; red, swollen, blistered, or peeling skin with or without fever; wheezing; tightness in the chest or throat; trouble breathing or talking; unusual hoarseness; or swelling of the mouth, face, lips, tongue, or throat.
  • Signs of infection like fever, chills, very bad sore throat, ear or sinus pain, cough, more sputum or change in color of sputum, pain with passing urine, mouth sores, or wound that will not heal.
  • Signs of bleeding like throwing up blood or throw up that looks like coffee grounds; coughing up blood; blood in the urine; black, red, or tarry stools; bleeding from the gums; vaginal bleeding that is not normal; bruises without a reason or that get bigger; or any bleeding that is very bad or that you cannot stop.
  • Signs of kidney problems like unable to pass urine, change in how much urine is passed, blood in the urine, or a big weight gain.
  • Feeling confused.
  • Feeling very tired or weak.
  • Feeling sleepy.
  • Dizziness or passing out.
  • Hallucinations (seeing or hearing things that are not there).
  • Change in eyesight, eye pain, or very bad eye irritation.
  • Change in the way your child acts.
  • Trouble controlling body movements, twitching, change in balance, trouble swallowing or speaking.
  • Not able to control passing urine.
  • Seizures.
  • A burning, numbness, or tingling feeling that is not normal.
  • A fast heartbeat.
  • A heartbeat that does not feel normal.
  • Shortness of breath, a big weight gain, swelling in the arms or legs.
  • Skin wound that will not heal.
  • Hearing loss.
  • Ringing in ears.
  • Very bad and sometimes deadly liver problems have happened with this drug. Call your child’s doctor right away if your child has signs of liver problems like dark urine, feeling tired, not hungry, upset stomach or stomach pain, light-colored stools, throwing up, or yellow skin or eyes.

What are some other side effects of this drug?

All drugs may cause side effects. However, many people have no side effects or only have minor side effects. Call your child’s doctor or get medical help if any of these side effects or any other side effects bother your child or do not go away:
  • Upset stomach or throwing up.
  • Hair loss.
These are not all of the side effects that may occur. If you have questions about side effects, call your child’s doctor. Call your child’s doctor for medical advice about side effects.
You may report side effects to your national health agency.

How is this drug best given?

Give this drug as ordered by your child’s doctor. Read all information given to you. Follow all instructions closely.
  • It is given as an infusion into a vein over a period of time.
  • Have your child pass urine often. Your child needs to empty his/her bladder often. Having your child drink lots of liquids will help.
  • Have your child drink lots of noncaffeine liquids every day unless told to drink less liquid by your child’s doctor.
  • If your child drinks grapefruit juice or eats grapefruit often, talk with your child’s doctor.
  • To help with mouth sores, have your child use a soft toothbrush or cotton swabs and rinse the mouth. Do not let your child use mouth rinses that have alcohol in them.

What do I do if my child misses a dose?

  • Call your child’s doctor to find out what to do.

How do I store and/or throw out this drug?

  • If you need to store this drug at home, talk with your child’s doctor, nurse, or pharmacist about how to store it.

General drug facts

  • If your child’s symptoms or health problems do not get better or if they become worse, call your child’s doctor.
  • Do not share your child’s drug with others and do not give anyone else’s drug to your child.
  • Keep a list of all your child’s drugs (prescription, natural products, vitamins, OTC) with you. Give this list to your child’s doctor.
  • Talk with your child’s doctor before giving your child any new drug, including prescription or OTC, natural products, or vitamins.
  • Keep all drugs in a safe place. Keep all drugs out of the reach of children and pets.
  • Check with your pharmacist about how to throw out unused drugs.
  • Some drugs may have another patient information leaflet. If you have any questions about this drug, please talk with your child’s doctor, nurse, pharmacist, or other health care provider.
  • If you think there has been an overdose, call your poison control center or get medical care right away. Be ready to tell or show what was taken, how much, and when it happened.

Consumer Information Use and Disclaimer

This information should not be used to decide whether or not to take this medicine or any other medicine. Only the healthcare provider has the knowledge and training to decide which medicines are right for a specific patient. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about this medicine. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to this medicine. This information is not specific medical advice and does not replace information you receive from the healthcare provider. You must talk with the healthcare provider for complete information about the risks and benefits of using this medicine.

Last Reviewed Date

2016-03-28

Copyright

© 2016 Wolters Kluwer Clinical Drug Information, Inc. and its affiliates and/or licensors. All rights reserved.