Instructions for Managing Side Effects of Your High-Dose Cyclophosphamide Treatment

This information will help you manage some of the side effects of your high-dose cyclophosphamide treatment while you’re at home.

Cyclophosphamide can irritate the lining of your bladder. To protect your bladder, follow the instructions below. If your doctor or nurse gave you instructions that are different from the ones below, follow the instructions that they gave you.

Before Your Treatment

The day before your treatment, drink at least 8 to 10 (8-ounce) servings (about 2 liters) of liquids.

  • Drink a variety of liquids, such as juice, water, soup, and ice-pops.
  • Don’t drink more than 1 (8-ounce) serving of caffeinated drinks such as coffee, tea, or cola.
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The Day of Your Treatment

The day of your treatment, drink at least 6 to 8 (8-ounce) servings (about 1.5 to 2 liters) of liquids. Drink before and after your treatment visit.

  • Drink a variety of liquids, such as juice, water, soup, and ice-pops.
  • Don’t drink more than 1 (8-ounce) serving of caffeinated drinks such as coffee, tea, or cola.
 

During your cyclophosphamide treatment, you’ll have an intravenous (IV) line. You’ll get fluids and a medication called mesna through your IV line. The fluids and mesna will help protect your bladder during your treatment.

While you’re awake, try to urinate every 3 to 4 hours for 24 hours after your treatment. Urinate before you go to bed. You don’t have to wake up at night to urinate.

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After Your Treatment

For 3 days after your treatment, drink 8 to 10 (8-ounce) servings (about 2 liters) of liquids every day.

  • Drink a variety of liquids, such as juice, water, soup, and ice-pops.
  • Don’t drink more than 1 (8-ounce) serving of caffeinated drinks such as coffee, tea, or cola each day.

To prevent nausea and vomiting, take your antinausea medications as instructed.

Ask your doctor before taking aspirin, other nonsteroidal anti-inflammatory drugs (NSAIDs), or vitamin E. These medications can cause bleeding. For more information, read our resource Common Medications Containing Aspirin and Other Nonsteroidal Anti-Inflammatory Drugs (NSAIDs).

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Call Your Doctor or Nurse if You:

  • Are unable to drink liquids the day after your treatment due to nausea, vomiting, or both
  • Have vomiting lasting more than 24 hours
  • Have pain while you urinate or blood in your urine
  • Have a fever of 100.4° F (38° C) or higher or chills
  • Have any unexpected or unexplained problems
  • Have any questions or concerns
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Daily Liquid Log

Keep track of the liquids you drink to make sure you’re meeting your goals. Make a checkmark for each cup of liquid that you drink.

Remember that your goal is to drink:

  • 8 to 10 (8-ounce) servings the day before your treatment
  • 6 to 8 (8-ounce) servings the day of your treatment
  • 8 to 10 (8-ounce) servings for 3 days after your treatment

1 cup is equal to 8 ounces.

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Day of treatment                    
Day 1 after treatment                    
Day 2 after treatment                    
Day 3 after treatment                    
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