Avonex; Avonex Pen; Rebif; Rebif Rebidose; Rebif Rebidose Titration Pack; Rebif Titration Pack
- It is used to treat MS (multiple sclerosis).
- If you have an allergy to interferon beta-1a or any other part of this drug.
- If you are allergic to any drugs like this one, any other drugs, foods, or other substances. Tell your doctor about the allergy and what signs you had, like rash; hives; itching; shortness of breath; wheezing; cough; swelling of face, lips, tongue, or throat; or any other signs.
- Tell dentists, surgeons, and other doctors that you use this drug.
- You may bleed more easily. Be careful and avoid injury. Use a soft toothbrush and an electric razor.
- You may have more chance of getting an infection. Wash hands often. Stay away from people with infections, colds, or flu.
- Have blood work checked as you have been told by the doctor. Talk with the doctor.
- Talk with your doctor before you drink alcohol.
- A lot of times, reactions happen where the shot was given. Sometimes, very bad reactions may happen. Check with your doctor if you have any reaction that bothers you or does not go away. Call your doctor right away if you have any break in the skin, color changes (blue or black), swelling, or drainage of fluid where the shot was given.
- This drug is made from human plasma (part of the blood) and may have viruses that may cause disease. This drug is screened, tested, and treated to lower the chance that it carries an infection. Talk with the doctor.
- Tell your doctor if you are pregnant or plan on getting pregnant. You will need to talk about the benefits and risks of using this drug while you are pregnant.
- Tell your doctor if you are breast-feeding. You will need to talk about any risks to your baby.
- Signs of an allergic reaction, like rash; hives; itching; red, swollen, blistered, or peeling skin with or without fever; wheezing; tightness in the chest or throat; trouble breathing or talking; unusual hoarseness; or swelling of the mouth, face, lips, tongue, or throat.
- Signs of infection like fever, chills, very bad sore throat, ear or sinus pain, cough, more sputum or change in color of sputum, pain with passing urine, mouth sores, or wound that will not heal.
- Signs of low mood (depression), thoughts of killing yourself, nervousness, emotional ups and downs, thinking that is not normal, anxiety, or lack of interest in life.
- Signs of bleeding like throwing up blood or throw up that looks like coffee grounds; coughing up blood; blood in the urine; black, red, or tarry stools; bleeding from the gums; vaginal bleeding that is not normal; bruises without a reason or that get bigger; or any bleeding that is very bad or that you cannot stop.
- Signs of thyroid problems like a change in weight without trying, feeling nervous and excitable, feeling restless, feeling very weak, hair thinning, low mood (depression), neck swelling, not able to focus, not able to handle heat or cold, period (menstrual) changes, shakiness, or sweating.
- Change in balance.
- Change in eyesight.
- Passing urine often.
- Shortness of breath.
- Chest pain or pressure or a fast heartbeat.
- Very bad dizziness or passing out.
- Very bad swelling.
- Very bad and sometimes deadly liver problems have happened with this drug. Call your doctor right away if you have signs of liver problems like dark urine, feeling tired, not hungry, upset stomach or stomach pain, light-colored stools, throwing up, or yellow skin or eyes.
- Flu-like signs. These include headache, weakness, fever, shakes, aches, pains, and sweating. Mild pain drugs may help.
- Upset stomach or throwing up.
- Belly pain.
- Muscle pain.
- Back pain.
- Feeling sleepy.
- Dry mouth.
- Do not use if the solution is cloudy, leaking, or has particles.
- Do not give into skin that is irritated, bruised, red, infected, or scarred.
- Wash your hands before and after use.
- Move the site where you give the shot with each shot.
- Follow how to give closely if you or a family member is giving the shot at home.
- Throw away needles in a needle/sharp disposal box. Do not reuse needles or other items. When the box is full, follow all local rules for getting rid of it. Talk with a doctor or pharmacist if you have any questions.
- It is given as a shot into a muscle.
- Do not shake.
- Before giving the shot, let it come to room temperature. Do not heat this drug.
- It is given as a shot into the fatty part of the skin.
- Take a missed dose as soon as you think about it and go back to your normal time.
- If the next dose is less than 48 hours away, call your doctor to find out what to do.
- Do not take 2 doses at the same time or extra doses.
- Store in a refrigerator. Do not freeze.
- Protect from heat.
- Protect from light.
- Throw away any part not used after use.
- Keep all drugs out of the reach of children and pets.
- Check with your pharmacist about how to throw out unused drugs.
- You may store unopened vials at room temperature. Throw away after 1 month.
- You may store syringes or pens at room temperature. Throw away after 7 days.
- If you cannot store in a refrigerator, you may store unused syringes or pens at room temperature for up to 30 days.
- If your symptoms or health problems do not get better or if they become worse, call your doctor.
- Do not share your drugs with others and do not take anyone else’s drugs.
- Keep a list of all your drugs (prescription, natural products, vitamins, OTC) with you. Give this list to your doctor.
- Talk with the doctor before starting any new drug, including prescription or OTC, natural products, or vitamins.
- Some drugs may have another patient information leaflet. If you have any questions about this drug, please talk with your doctor, pharmacist, or other health care provider.
- If you think there has been an overdose, call your poison control center or get medical care right away. Be ready to tell or show what was taken, how much, and when it happened.
If you have any questions or concerns, talk with a member of your healthcare team. You can reach them Monday through Friday from 9:00 am to 5:00 pm at ____________________. After 5:00 pm, during the weekend, and on holidays, please call____________________. If there’s no number listed, or you’re not sure, call 212-639-2000.