Intraperitoneal Therapy

This information will help you prepare for your intraperitoneal (IP) therapy.

About Your IP Therapy

Your peritoneal space is the area in between the muscles and the organs in your abdomen (belly). There is a little fluid in between the lining and the organs.

In IP therapy, anticancer medication is mixed with fluids and injected directly into your peritoneal space to mix with the small amount of fluid there. This is done through an access port and catheter. Your surgeon will insert the port into a pocket under the skin near your rib cage and the catheter into your peritoneal space during surgery (see Figure 1).

Figure 1.

The port has a raised chamber. On top of the chamber is a self-sealing rubber septum (disc). The chamber also has a side arm for attaching the catheter (see Figure 2). You may see or feel the port under your skin. This is normal.

Figure 2: The port and catheter

During IP therapy, the medication comes into direct contact with the cancer in your peritoneal space. The medication is left in the space to “bathe” the cancer. This method allows a higher concentration of the medication to be given. Your nurse will teach you about the medication that will be used for your IP therapy.

You may receive your IP therapy as an inpatient or an outpatient. Your condition and the type of medication that you need will determine:

  • Where you will receive your IP therapy.
  • How many treatments you will have.
  • How long your therapy will last.

Some people may need to switch between having intravenous (through a vein) therapy and IP therapy given at different times.

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Preparing for Your IP Therapy

  • Eat a light dinner the night before and a light breakfast on the morning of your treatment.
  • Dress comfortably on the morning of your treatment. Wear loose fitting shirts and pants with an elastic band or a draw string.
  • If you wish, bring a CD player or iPod so you can listen to music during treatment. There will also be a TV in the room where you receive your treatment. Someone can also stay with you during your treatment.
  • You can bring food and drinks with you into the treatment room.

Arrange for someone to take you home

You must have a responsible adult take you home at least the first few times that you come in for treatment because some of the medication may make you drowsy. If you don’t have someone who can do this, please call one of the agencies below. They will help find someone to take you home.

In New York:
Partners in Care: 888-735-8913
Prime Care: 212-944-0244
In New York or New Jersey:
Caring People: 877-227-4649
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During Your IP Therapy

During your IP therapy, you will need to stay in your bed or chair unless you need to go to the bathroom. You may receive fluids or medication intravenously (through your vein).

Your nurse will put a needle through your skin and into the self-sealing disc on the port chamber. This will feel like a small pinprick. He or she will tape the needle in place and cover it with a small dressing.

The fluid and medication mixture will be in a bag that is attached to the needle. This mixture will flow into your peritoneal space. You may need to have more solution after your treatment to improve the bathing of your peritoneal space.

After the solution has flowed into your peritoneal space, your nurse will remove the needle and place a bandage on the site. This bandage can be removed after about 30 minutes.

If you’re inpatient and unable to get out of bed, your nurse will ask you to move from side to side in bed a few times. This will help move the solution throughout your peritoneal space. Your IP therapy will then be complete and you can get out of bed. The solution will be absorbed by your body over the next few days.

The treatment time varies, but it is usually no more than 1½ to 2 hours. Some treatments may last as long as 6 hours because of the extra IV fluid that has to be given. Ask your doctor or nurse how long your treatment may take.

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Side Effects of IP Therapy

The side effects of IP therapy are different depending on the person. Below are the most common side effects and ways to relieve them. The side effects may be caused by the amount of fluids that are injected into your peritoneal space during your IP therapy or by the medication itself. You may have none, some, or all of these.

Abdominal pressure or bloating

  • After your treatment is finished, try to walk around. This will help with the pressure or bloating. Wear comfortable clothes, such as pants with an elastic band, for your treatments and for a few days after your treatments.

Full bladder or frequent need to urinate

  • Try to empty your bladder just before you start your treatments. You can also use the restroom during your treatments.

Faster breathing

  • Elevate your head during your treatment. When your treatment is finished, you can walk around or sit upright in a chair.

Nausea and vomiting

  • Your doctor or nurse may give you an antinausea medication before or during your IP therapy. Your doctor may also prescribe this medication for you to take at home as needed.

Decreased appetite

  • Try to eat smaller meals more often and drink liquid nutritional supplements.
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Caring for Your Peritoneal Port at Home

Since the access port is under your skin, you do not need to cover or bandage it. You can bathe and shower and follow your normal diet.

Having a port and catheter should not limit your activities. Ask your doctor or nurse about going back to your normal activities. You can begin to exercise after you have recovered from surgery and your incision has healed.

Inspect the skin around your port daily and call your doctor or nurse if there are any problems.

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Call Your Doctor or Nurse if You Have:

  • Severe or constant stomach pain
  • A temperature of 100.4° F (38° C) or higher
  • Redness, swelling, or tenderness in the area around your port site
  • Nausea or vomiting that lasts more than 24 hours
  • Diarrhea that lasts more than 24 hours
  • Constipation that lasts more than 24 hours
  • An inability to eat or drink for more than 24 hours
  • Any unexpected or unexplained problems
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