Adult Medication

Brand Names: US

Eligard; Lupron Depot; Lupron Depot-Ped

Brand Names: Canada

Eligard; Lupron; Lupron Depot

What is this drug used for?

  • It is used to treat endometriosis.
  • It is used to treat anemia caused by fibroids of the uterus.
  • It is used to treat prostate cancer.
  • It may be given to you for other reasons. Talk with the doctor.

What do I need to tell my doctor BEFORE I take this drug?

For all patients taking this drug:

  • If you have an allergy to leuprolide or any other part of this drug.
  • If you are allergic to any drugs like this one, any other drugs, foods, or other substances. Tell your doctor about the allergy and what signs you had, like rash; hives; itching; shortness of breath; wheezing; cough; swelling of face, lips, tongue, or throat; or any other signs.


  • If you have unexplained vaginal bleeding.
  • If you are pregnant or may be pregnant. Do not take this drug if you are pregnant.
  • If you are breast-feeding. Do not breast-feed while you take this drug.
This is not a list of all drugs or health problems that interact with this drug.
Tell your doctor and pharmacist about all of your drugs (prescription or OTC, natural products, vitamins) and health problems. You must check to make sure that it is safe for you to take this drug with all of your drugs and health problems. Do not start, stop, or change the dose of any drug without checking with your doctor.

What are some things I need to know or do while I take this drug?

For all patients taking this drug:

  • Tell all of your health care providers that you take this drug. This includes your doctors, nurses, pharmacists, and dentists.
  • Avoid driving and doing other tasks or actions that call for you to be alert until you see how this drug affects you.
  • This drug may raise some hormone levels in your body during the first few weeks of taking it. Disease signs may get worse before getting better. Tell your doctor if you have any new signs or if your disease signs are worse for longer than a few weeks after starting this drug.
  • This drug lowers some hormone levels in your body. This may cause some effects like change in breast size, breast soreness or tenderness, testicle changes in men, change in sex ability in men, hot flashes, or sweating. Talk with your doctor.
  • Have blood work checked as you have been told by the doctor. Talk with the doctor.
  • Have a bone density test as you have been told by your doctor. Talk with your doctor.
  • This drug may affect certain lab tests. Tell all of your health care providers and lab workers that you take this drug.
  • If you have high blood sugar (diabetes), you will need to watch your blood sugar closely.
  • If you smoke, talk with your doctor.
  • A very bad pituitary gland problem (pituitary apoplexy) has rarely happened with this drug. Most of the time, this has happened within 2 weeks after the first dose. Call your doctor right away if you have a sudden headache, throwing up, passing out, mood changes, eye weakness, not able to move your eyes, or change in eyesight.
  • This drug may cause weak bones. This may happen more often if used for a long time. This may raise the chance of broken bones. Call your doctor right away if you have bone pain.
  • A higher chance of stroke or very bad and sometimes deadly heart problems have been noted with the use of drugs like this drug in men. The chance is low, but get medical help right away if you have chest pain or pressure, a change in strength on 1 side that is greater than the other, trouble speaking or thinking, change in balance, or change in eyesight.
  • Some products are not approved for use in people who are 65 or older or in children. Talk with your doctor.


  • The chance of very bad and sometimes deadly problems may be raised in people who have growths on or near the spine or spinal cord or bladder blockage. Talk with your doctor.


  • Most of the time, this drug stops you from having a period (menstrual bleeding). This is not a method of birth control. Use a non-hormone type of birth control like condoms to prevent pregnancy while taking this drug.
  • If you miss doses of this drug, bleeding between cycles can happen. Talk with your doctor.
  • This drug may cause harm to the unborn baby if you take it while you are pregnant.
  • A pregnancy test will be done to show that you are NOT pregnant before starting this drug. If you get pregnant while taking this drug, call your doctor right away.

What are some side effects that I need to call my doctor about right away?

WARNING/CAUTION: Even though it may be rare, some people may have very bad and sometimes deadly side effects when taking a drug. Tell your doctor or get medical help right away if you have any of the following signs or symptoms that may be related to a very bad side effect:

For all patients taking this drug:

  • Signs of an allergic reaction, like rash; hives; itching; red, swollen, blistered, or peeling skin with or without fever; wheezing; tightness in the chest or throat; trouble breathing or talking; unusual hoarseness; or swelling of the mouth, face, lips, tongue, or throat.
  • Signs of low mood (depression), thoughts of killing yourself, nervousness, emotional ups and downs, thinking that is not normal, anxiety, or lack of interest in life.
  • Signs of high blood sugar like confusion, feeling sleepy, more thirst, more hungry, passing urine more often, flushing, fast breathing, or breath that smells like fruit.
  • Signs of infection like fever, chills, very bad sore throat, ear or sinus pain, cough, more sputum or change in color of sputum, pain with passing urine, mouth sores, or wound that will not heal.
  • Memory problems or loss.
  • Very bad headache.
  • Swelling, warmth, numbness, change of color, or pain in a leg or arm.
  • Coughing up blood.
  • Bone pain that is new or worse.
  • Not able to pass urine or change in how much urine is passed.
  • Very bad back pain.
  • Seizures.
  • Black, tarry, or bloody stools.
  • Throwing up blood or throw up that looks like coffee grounds.
  • Blood in the urine.
  • A burning, numbness, or tingling feeling that is not normal.
  • Very bad dizziness or passing out.
  • Shortness of breath.
  • Fast or slow heartbeat.
  • A heartbeat that does not feel normal.
  • Swelling in the arms or legs.
  • Not able to move.


  • For women, still having a period.
  • Vaginal itching or discharge.
  • Vaginal irritation.

What are some other side effects of this drug?

All drugs may cause side effects. However, many people have no side effects or only have minor side effects. Call your doctor or get medical help if any of these side effects or any other side effects bother you or do not go away:

For all patients taking this drug:

  • Headache.
  • Feeling tired or weak.
  • Upset stomach or throwing up.
  • Not able to sleep.
  • Dizziness.
  • Irritation where the shot is given.
  • Joint pain.


  • Pimples (acne).
  • Muscle pain.
  • Mood changes.
  • A change in weight without trying.
  • Feeling nervous and excitable.
These are not all of the side effects that may occur. If you have questions about side effects, call your doctor. Call your doctor for medical advice about side effects.
You may report side effects to your national health agency.

How is this drug best taken?

Use this drug as ordered by your doctor. Read all information given to you. Follow all instructions closely.
  • It is given as a shot.
  • Some products need to be given into the fatty part of the skin. Some products need to be given into a muscle. Talk with your doctor or pharmacist if you are not sure how to use this drug.
  • Your doctor may teach you how to give the shot.
  • Follow how to use carefully.
  • Wash your hands before and after use.
  • Wear gloves while mixing and giving this drug.
  • Do not use if the solution is cloudy, leaking, or has particles.
  • Do not use if solution changes color.
  • Throw away needles in a needle/sharp disposal box. Do not reuse needles or other items. When the box is full, follow all local rules for getting rid of it. Talk with a doctor or pharmacist if you have any questions.
  • Keep using this drug as you have been told by your doctor or other health care provider, even if you feel well.
  • To gain the most benefit, do not miss doses.

What do I do if I miss a dose?

  • Call your doctor to find out what to do.

How do I store and/or throw out this drug?

  • Most of the time, this drug will be given in a hospital or doctor’s office. If stored at home, follow how to store as you were told by the doctor.
  • Keep all drugs in a safe place. Keep all drugs out of the reach of children and pets.
  • Check with your pharmacist about how to throw out unused drugs.

General drug facts

  • If your symptoms or health problems do not get better or if they become worse, call your doctor.
  • Do not share your drugs with others and do not take anyone else’s drugs.
  • Keep a list of all your drugs (prescription, natural products, vitamins, OTC) with you. Give this list to your doctor.
  • Talk with the doctor before starting any new drug, including prescription or OTC, natural products, or vitamins.
  • Some drugs may have another patient information leaflet. If you have any questions about this drug, please talk with your doctor, nurse, pharmacist, or other health care provider.
  • If you think there has been an overdose, call your poison control center or get medical care right away. Be ready to tell or show what was taken, how much, and when it happened.

Consumer Information Use and Disclaimer

This information should not be used to decide whether or not to take this medicine or any other medicine. Only the healthcare provider has the knowledge and training to decide which medicines are right for a specific patient. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about this medicine. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to this medicine. This information is not specific medical advice and does not replace information you receive from the healthcare provider. You must talk with the healthcare provider for complete information about the risks and benefits of using this medicine.

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