Adult Medication

Brand Names: US

Keppra; Keppra XR; Roweepra; Spritam

Brand Names: Canada

Abbott-Levetiracetam; ACT Levetiracetam; Apo-Levetiracetam; Auro-Levetiracetam; Dom-Levetiracetam; JAMP-Levetiracetam; Keppra; PHL-Levetiracetam; PMS-Levetiracetam; PRO-Levetiracetam; RAN-Levetiracetam

What is this drug used for?

  • It is used to treat seizures.
  • It may be given to you for other reasons. Talk with the doctor.

What do I need to tell my doctor BEFORE I take this drug?

  • If you have an allergy to levetiracetam or any other part of this drug.
  • If you are allergic to any drugs like this one, any other drugs, foods, or other substances. Tell your doctor about the allergy and what signs you had, like rash; hives; itching; shortness of breath; wheezing; cough; swelling of face, lips, tongue, or throat; or any other signs.
  • If you have kidney problems or are on dialysis. Some brands of this drug are not to be used in people who have kidney problems.
  • If you are breast-feeding or plan to breast-feed.
This is not a list of all drugs or health problems that interact with this drug.
Tell your doctor and pharmacist about all of your drugs (prescription or OTC, natural products, vitamins) and health problems. You must check to make sure that it is safe for you to take this drug with all of your drugs and health problems. Do not start, stop, or change the dose of any drug without checking with your doctor.

What are some things I need to know or do while I take this drug?

All products:

  • Tell all of your health care providers that you take this drug. This includes your doctors, nurses, pharmacists, and dentists.
  • Avoid driving and doing other tasks or actions that call for you to be alert until you see how this drug affects you.
  • Have blood work checked as you have been told by the doctor. Talk with the doctor.
  • Do not stop taking this drug all of a sudden without calling your doctor. You may have a greater risk of seizures. If you need to stop this drug, you will want to slowly stop it as ordered by your doctor.
  • This drug may cause behavior changes and mental or mood problems. Talk with the doctor.
  • If you are 65 or older, use this drug with care. You could have more side effects.
  • Use with care in children. Talk with the doctor.
  • Children younger than 4 years old will need to have their blood pressure checked often. Talk with the doctor.
  • Tell your doctor if you are pregnant or plan on getting pregnant. You will need to talk about the benefits and risks of using this drug while you are pregnant.
  • This drug may not work as well during pregnancy. Talk with the doctor.

Extended-release tablets (Keppra XR):

  • You may see something that looks like the tablet in your stool. This is normal and not a cause for concern. If you have questions, talk with your doctor.

What are some side effects that I need to call my doctor about right away?

WARNING/CAUTION: Even though it may be rare, some people may have very bad and sometimes deadly side effects when taking a drug. Tell your doctor or get medical help right away if you have any of the following signs or symptoms that may be related to a very bad side effect:
  • Signs of an allergic reaction, like rash; hives; itching; red, swollen, blistered, or peeling skin with or without fever; wheezing; tightness in the chest or throat; trouble breathing or talking; unusual hoarseness; or swelling of the mouth, face, lips, tongue, or throat.
  • Signs of infection like fever, chills, very bad sore throat, ear or sinus pain, cough, more sputum or change in color of sputum, pain with passing urine, mouth sores, or wound that will not heal.
  • If seizures are worse or not the same after starting this drug.
  • Hallucinations (seeing or hearing things that are not there).
  • Feeling very tired or weak.
  • Very bad dizziness or passing out.
  • Change in balance.
  • Trouble walking.
  • Feeling very sleepy.
  • Any unexplained bruising or bleeding.
  • Very bad headache.
  • Patients who take this drug may be at a greater risk of having thoughts or actions of suicide. The risk may be greater in people who have had these thoughts or actions in the past. Call the doctor right away if signs like low mood (depression), nervousness, restlessness, grouchiness, panic attacks, or changes in mood or actions are new or worse. Call the doctor right away if any thoughts or actions of suicide occur.
  • A very bad skin reaction (Stevens-Johnson syndrome/toxic epidermal necrolysis) may happen. It can cause very bad health problems that may not go away, and sometimes death. Get medical help right away if you have signs like red, swollen, blistered, or peeling skin (with or without fever); red or irritated eyes; or sores in your mouth, throat, nose, or eyes.

What are some other side effects of this drug?

All drugs may cause side effects. However, many people have no side effects or only have minor side effects. Call your doctor or get medical help if any of these side effects or any other side effects bother you or do not go away:
  • Loose stools (diarrhea).
  • Dizziness.
  • Feeling sleepy.
  • Stuffy nose.
  • Nose and throat irritation.
  • Belly pain.
  • Not able to sleep.
  • Feeling tired or weak.
  • Headache.
  • Upset stomach or throwing up.
  • Not hungry.
These are not all of the side effects that may occur. If you have questions about side effects, call your doctor. Call your doctor for medical advice about side effects.
You may report side effects to your national health agency.

How is this drug best taken?

Use this drug as ordered by your doctor. Read all information given to you. Follow all instructions closely.

All oral products:

  • Keep taking this drug as you have been told by your doctor or other health care provider, even if you feel well.
  • Take with or without food. Take with food if it causes an upset stomach.
  • Take this drug at the same time of day.

Oral-disintegrating tablet/tablet for oral suspension:

  • Do not swallow whole. Do not chew, break, or crush.
  • Do not take chipped or broken tablets.
  • Do not push the tablet out of the foil when opening. Use dry hands to take it from the foil. Place the tablet on your tongue and follow with a sip of liquid before you swallow. Swallow only after the tablet melts.
  • Whole tablet(s) may also be mixed in a cup with a small amount of liquid like 1 tablespoon (15 mL) or enough to cover the drug. Let the tablet(s) melt all the way and drink the mixture right away. If any drug is left in the cup, rinse cup with a small amount of liquid, swirl, and drink.


  • Measure liquid doses carefully. Use the measuring device that comes with this drug. If there is none, ask the pharmacist for a device to measure this drug.

All other oral products:

  • Swallow whole. Do not chew or crush.

Short-acting tablets:

  • You may break the tablet in half. Do not chew or crush.

Extended-release tablets:

  • Do not split or break tablet.

Extended-release tablets (Elepsia XR®):

  • Each tablet has 2 layers, a blue layer and a white to off-white layer. If you do not see both of these layers, do not take the tablet. Call your pharmacist.


  • It is given as an infusion into a vein over a period of time.

What do I do if I miss a dose?

All oral products:

  • Take a missed dose as soon as you think about it.
  • If it is close to the time for your next dose, skip the missed dose and go back to your normal time.
  • Do not take 2 doses at the same time or extra doses.


  • Call your doctor to find out what to do.

How do I store and/or throw out this drug?

All oral products:

  • Store at room temperature.
  • Protect from light.
  • Store in a dry place. Do not store in a bathroom.


  • If you need to store this drug at home, talk with your doctor, nurse, or pharmacist about how to store it.

All products:

  • Keep all drugs in a safe place. Keep all drugs out of the reach of children and pets.
  • Check with your pharmacist about how to throw out unused drugs.

General drug facts

  • If your symptoms or health problems do not get better or if they become worse, call your doctor.
  • Do not share your drugs with others and do not take anyone else’s drugs.
  • Keep a list of all your drugs (prescription, natural products, vitamins, OTC) with you. Give this list to your doctor.
  • Talk with the doctor before starting any new drug, including prescription or OTC, natural products, or vitamins.
  • Some drugs may have another patient information leaflet. If you have any questions about this drug, please talk with your doctor, nurse, pharmacist, or other health care provider.
  • If you think there has been an overdose, call your poison control center or get medical care right away. Be ready to tell or show what was taken, how much, and when it happened.

Consumer Information Use and Disclaimer

This information should not be used to decide whether or not to take this medicine or any other medicine. Only the healthcare provider has the knowledge and training to decide which medicines are right for a specific patient. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about this medicine. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to this medicine. This information is not specific medical advice and does not replace information you receive from the healthcare provider. You must talk with the healthcare provider for complete information about the risks and benefits of using this medicine.

Last Reviewed Date



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