Lidocaine (Topical)

Adult Medication

Brand Names: US

7T Lido; Alocane Emergency Burn Max Str [OTC]; Anastia; AneCream [OTC]; AneCream5 [OTC]; Astero; CidalEaze [DSC]; Eha; Glydo; LC-4 Lidocaine [OTC] [DSC]; LC-5 Lidocaine [OTC]; LDO Plus; LevigoSP [OTC]; Lido-K; Lidocaine PAK; Lidocaine Plus [OTC]; Lidocin [DSC]; Lidoderm; LidoDose [OTC]; Lidopac; Lidopin; LidoRx; Lidotral; Lidotrans 5 Pak; Lidotrex; Lidovex [DSC]; Lidovin [DSC]; Lidozion; Lidozol [DSC]; LMX 4 Plus [OTC]; LMX 4 [OTC]; LMX 5 [OTC]; NeuroMed7 [OTC]; Numbonex; Pain Relieving [OTC]; Predator [OTC]; Premium Lidocaine; Prozena [DSC]; Prozena [OTC] [DSC]; RectaSmoothe [OTC]; RectiCare [OTC]; Topicaine 5 [OTC]; Topicaine [OTC] [DSC]; Tranzarel [DSC]; Venipuncture Px1 Phlebotomy; Xolido XP [OTC]; Xolido [OTC]; Xryliderm; Xylocaine [DSC]; Zeyocaine; Zingo; ZTlido

Brand Names: Canada



Viscous lidocaine

  • Very bad health problems (like seizures and heart that stops working) and death have happened in children younger than 3 years old. In these cases, this drug was not used how it was recommended. Do not use this drug to treat infants and children with teething pain. Talk with the doctor.
  • This drug must only be used in children younger than 3 years old when other treatments cannot be used. If using in a child younger than 3 years old for a reason other than teething pain, follow how to give as you were told by the doctor. Talk with the doctor.

What is this drug used for?

  • It is used to stop pain.
  • It is used to treat painful nerve diseases.
  • It is used to treat signs of hemorrhoids or rectal irritation.
  • It is used to ease long-term pain problems.
  • It is used to ease pain from skin irritations.
  • It is used to ease pain caused by shingles.
  • It is used to treat mouth sores.
  • It may be given to you for other reasons. Talk with the doctor.

What do I need to tell my doctor BEFORE I take this drug?

All products:

  • If you have an allergy to lidocaine or any other part of this drug.
  • If you are allergic to any drugs like this one, any other drugs, foods, or other substances. Tell your doctor about the allergy and what signs you had, like rash; hives; itching; shortness of breath; wheezing; cough; swelling of face, lips, tongue, or throat; or any other signs.

All rectal and skin products:

  • If there is an infection where this drug will be used.
  • If you have broken skin or open wounds where the drug will be used.

All skin products:

  • If a large area needs to be treated.

This is not a list of all drugs or health problems that interact with this drug.

Tell your doctor and pharmacist about all of your drugs (prescription or OTC, natural products, vitamins) and health problems. You must check to make sure that it is safe for you to take this drug with all of your drugs and health problems. Do not start, stop, or change the dose of any drug without checking with your doctor.

What are some things I need to know or do while I take this drug?

All products:

  • Tell all of your health care providers that you take this drug. This includes your doctors, nurses, pharmacists, and dentists.
  • A severe blood problem called methemoglobinemia has happened with drugs like this one. The risk may be raised in people who have glucose-6-phosphate dehydrogenase (G6PD) deficiency, heart problems, or lung problems. The risk may also be raised while taking certain other drugs and in infants younger than 6 months of age. Tell your doctor if you have ever had methemoglobinemia.
  • If you are 65 or older, use this drug with care. You could have more side effects.
  • Tell your doctor if you are pregnant or plan on getting pregnant. You will need to talk about the benefits and risks of using this drug while you are pregnant.
  • Tell your doctor if you are breast-feeding. You will need to talk about any risks to your baby.

All skin products:

  • Do not use coverings (bandages, dressings, make-up) unless told to do so by the doctor.

All rectal and skin products:

  • Talk with your doctor before you use other drugs or products on your skin.
  • Do not use this drug for longer than you were told by your doctor.
  • Do not scratch or rub the skin while it is numb. Do not let it get very hot or very cold.
  • Do not put on cuts, scrapes, or damaged skin unless the doctor tells you to.
  • Avoid use of heat sources (such as sunlamps, tanning beds, heating pads, electric blankets, heat lamps, saunas, hot tubs, heated waterbeds). Avoid long, hot baths or sunbathing. Your temperature may rise and cause too much drug to pass into your body.

All rectal products and skin products other than skin patch and skin system:

  • This drug may cause harm if swallowed. If this drug is swallowed, call a doctor or poison control center right away.
  • Different brands of this drug may be for use in different ages of children. Talk with the doctor before giving this drug to a child.

Skin patch and skin system:

  • Do not get this drug wet. It may not stick. Do not bathe, swim, or shower while you are wearing this drug.
  • Do not switch between different brands of this drug without first talking with the doctor.
  • It is common to have skin reactions where this drug is put on during or right after treatment. This includes blisters, bruising, burning or abnormal feeling, change in color, swelling, redness, pain, itching, peeling, flaking, or pimples. Most of the time, these skin reactions go away within a few minutes to hours. Call your doctor if any of these effects are very bad, bother you, or do not go away.
  • This drug may cause harm if chewed or swallowed. If this drug has been put in the mouth, call a doctor or poison control center right away.

Skin system (ZTlido):

  • This drug may be put on after use of moderate heat like after 15 minutes of using a heating pad on a medium setting. This drug may also be used during moderate exercise like biking for 30 minutes.

All oral products:

  • Different brands of this drug may be for use in different ages of children. Talk with the doctor before giving this drug to a child.
  • Do not eat while your mouth feels numb. You may bite your tongue.

What are some side effects that I need to call my doctor about right away?

WARNING/CAUTION: Even though it may be rare, some people may have very bad and sometimes deadly side effects when taking a drug. Tell your doctor or get medical help right away if you have any of the following signs or symptoms that may be related to a very bad side effect:

All products:

  • Signs of an allergic reaction, like rash; hives; itching; red, swollen, blistered, or peeling skin with or without fever; wheezing; tightness in the chest or throat; trouble breathing, swallowing, or talking; unusual hoarseness; or swelling of the mouth, face, lips, tongue, or throat.
  • Signs of infection like fever, chills, very bad sore throat, ear or sinus pain, cough, more sputum or change in color of sputum, pain with passing urine, mouth sores, or wound that will not heal.
  • Signs of too much acid in the blood (acidosis) like confusion; fast breathing; fast heartbeat; a heartbeat that does not feel normal; very bad stomach pain, upset stomach, or throwing up; feeling very sleepy; shortness of breath; or feeling very tired or weak.
  • Signs of methemoglobinemia like a blue or gray color of the lips, nails, or skin; a heartbeat that does not feel normal; seizures; very bad dizziness or passing out; very bad headache; feeling very sleepy; feeling tired or weak; or shortness of breath. This effect is rare but may be deadly if it happens.
  • Trouble breathing, slow breathing, or shallow breathing.
  • Very bad numbness and tingling.
  • Feeling lightheaded, sleepy, confused, or having blurred eyesight.
  • Seizures.
  • Change in eyesight.
  • Feeling nervous and excitable.
  • Dizziness or passing out.
  • Ringing in ears.
  • Upset stomach or throwing up.
  • Feeling hot or cold.
  • Shakiness.
  • Twitching.
  • Slow heartbeat.
  • Very bad irritation where this drug is used.

All rectal products:

  • Bleeding from rectum or rectal pain.

What are some other side effects of this drug?

All drugs may cause side effects. However, many people have no side effects or only have minor side effects. Call your doctor or get medical help if any of these side effects or any other side effects bother you or do not go away:

All products:

  • Irritation where this drug is used.

All rectal products and skin products other than skin patch and skin system:

  • Swelling.
  • Redness.
  • Change in color of skin.

These are not all of the side effects that may occur. If you have questions about side effects, call your doctor. Call your doctor for medical advice about side effects.

You may report side effects to your national health agency.

How is this drug best taken?

Use this drug as ordered by your doctor. Read all information given to you. Follow all instructions closely.

All rectal products:

  • Wash your hands before and after use.
  • Follow how to use as you have been told by the doctor or read the package insert.
  • Put on clean, dry skin.
  • Put this drug on as you have been told by the doctor or on the package labeling.

All skin products:

  • Do not take this drug by mouth. Use on your skin only. Keep out of your mouth, nose, and eyes (may burn).
  • If you get this drug in any of these areas, rinse well with water.
  • Clean affected part before use. Make sure to dry well.
  • Put on clean, dry, healthy skin.

All skin products other than skin patch and skin system:

  • Wash your hands before and after use. Do not wash your hands after use if putting this on your hand.

Skin liquid and spray:

  • This drug may catch on fire. Do not use near an open flame or while smoking.

Skin liquid:

  • Some of these drugs need to be shaken before use. Be sure you know if this product needs to be shaken before using it.


  • If you are using the spray for your face, spray it on your hand or gauze and then put it on your face.

Skin patch and skin system:

  • Wash your hands before and after use.
  • Put on the most painful parts of the skin.
  • Trim to cover the affected skin.
  • Put on at the same time of day.
  • Leave on for up to 12 hours.
  • After you take this drug off, do not put another one on that area of skin for 12 hours.
  • Take off this drug right away if it burns.
  • After you take off a skin patch or system, be sure to fold the sticky sides to each other. Throw away used patches, used systems, and pieces that were cut where children and pets cannot get to them.

All oral products:

  • Follow how to use carefully.
  • If using as a rinse, swish it in mouth as long as you can. Swallow or spit out as you are told.
  • If putting on with a cotton swab, put on affected part as your doctor or the label tells you.
  • Do not eat anything for at least 60 minutes (1 hour) after you use this drug.

Oral liquid:

  • Shake well before use.
  • Measure liquid doses carefully.

What do I do if I miss a dose?

  • If you use this drug on a regular basis, use a missed dose as soon as you think about it.
  • If it is close to the time for your next dose, skip the missed dose and go back to your normal time.
  • Do not put on 2 doses at the same time or extra doses.
  • Many times this drug is used on an as needed basis. Do not use more often than told by the doctor.

How do I store and/or throw out this drug?

All products:

  • Store at room temperature.
  • Keep all drugs in a safe place. Keep all drugs out of the reach of children and pets.
  • Throw away unused or expired drugs. Do not flush down a toilet or pour down a drain unless you are told to do so. Check with your pharmacist if you have questions about the best way to throw out drugs. There may be drug take-back programs in your area.

All skin products other than skin patch and skin system:

  • Do not freeze.

Skin liquid and spray:

  • Protect from heat or open flame.


  • Do not puncture.

Skin patch and skin system:

  • Store in the envelope that this drug comes in to help keep away from children. Do not open the envelope until you are ready to use this drug.

General drug facts

  • If your symptoms or health problems do not get better or if they become worse, call your doctor.
  • Do not share your drugs with others and do not take anyone else’s drugs.
  • Keep a list of all your drugs (prescription, natural products, vitamins, OTC) with you. Give this list to your doctor.
  • Talk with the doctor before starting any new drug, including prescription or OTC, natural products, or vitamins.
  • Some drugs may have another patient information leaflet. If you have any questions about this drug, please talk with your doctor, nurse, pharmacist, or other health care provider.
  • If you think there has been an overdose, call your poison control center or get medical care right away. Be ready to tell or show what was taken, how much, and when it happened.

Consumer Information Use and Disclaimer

This information should not be used to decide whether or not to take this medicine or any other medicine. Only the healthcare provider has the knowledge and training to decide which medicines are right for a specific patient. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about this medicine. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to this medicine. This information is not specific medical advice and does not replace information you receive from the healthcare provider. You must talk with the healthcare provider for complete information about the risks and benefits of using this medicine.

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