Adult Medication

Brand Names: US

Depo-Provera; Depo-SubQ Provera 104; Provera

Brand Names: Canada

Alti-MPA; Apo-Medroxy; Depo-Prevera; Depo-Provera; Dom-Medroxyprogesterone; Gen-Medroxy; Medroxy; Medroxyprogesterone Acetate Injectable Suspension USP; Novo-Medrone; PMS-Medroxyprogesterone; Provera; Provera-Pak; Teva-Medroxyprogesterone


  • Using this drug for birth control or pain caused by endometriosis may cause bone loss. Bone loss is greater the longer the drug is used. It is not known what the effects will be on bones when used in teenaged and young adult women.
  • Do not use this drug for birth control for a long time unless other options will not work.
  • This drug does not stop the spread of diseases like HIV or hepatitis that are passed through blood or having sex. Do not have any kind of sex without using a latex or polyurethane condom. Do not share needles or other things like toothbrushes or razors. Talk with your doctor.

Hormone replacement therapy (HRT):

  • Do not take with estrogens to prevent heart disease or dementia. Using estrogens may raise your chances of having a heart attack, a stroke, breast cancer, a blood clot, or dementia.
  • Use estrogens with or without progestin for the shortest time needed at the lowest useful dose.

What is this drug used for?

  • It is used to prevent pregnancy.
  • It is used to lower the chance of endometrial changes in women after change of life who are getting estrogen therapy.
  • It is used to treat pain caused by endometriosis.
  • It is used to treat uterine bleeding due to hormonal imbalance.
  • It is used to treat endometrial cancer.
  • It is used to treat kidney cancer.
  • It is used to treat females who do not have a monthly period cycle.
  • It may be given to you for other reasons. Talk with the doctor.

What do I need to tell my doctor BEFORE I take this drug?

For all patients taking this drug:

  • If you have an allergy to medroxyprogesterone or any other part of this drug.
  • If you are allergic to any drugs like this one, any other drugs, foods, or other substances. Tell your doctor about the allergy and what signs you had, like rash; hives; itching; shortness of breath; wheezing; cough; swelling of face, lips, tongue, or throat; or any other signs.
  • If you have had any of these health problems: Bleeding disorder; blood clots or risk of having a blood clot; breast cancer; liver disease; heart attack; stroke; or tumor where estrogen or progesterone make it grow.
  • If you have had any of these health problems: Cancer of the uterus, ovary, cervix, or vagina; or vaginal bleeding where the cause is not known.

For all reasons other than cancer treatment:

  • If you are pregnant or may be pregnant. Do not take this drug if you are pregnant.
This is not a list of all drugs or health problems that interact with this drug.
Tell your doctor and pharmacist about all of your drugs (prescription or OTC, natural products, vitamins) and health problems. You must check to make sure that it is safe for you to take this drug with all of your drugs and health problems. Do not start, stop, or change the dose of any drug without checking with your doctor.

What are some things I need to know or do while I take this drug?

All products:

  • Tell all of your health care providers that you take this drug. This includes your doctors, nurses, pharmacists, and dentists.
  • If you have high blood sugar (diabetes), you will need to watch your blood sugar closely.
  • Have your blood pressure checked often. Talk with your doctor.
  • Have a bone density test as you have been told by your doctor. Talk with your doctor.
  • Take calcium and vitamin D as you were told by your doctor.
  • Be sure to have regular breast exams and gynecology check-ups. Your doctor will tell you how often to have these. You will also need to do breast self-exams as your doctor has told you. Talk with your doctor.
  • This drug may affect certain lab tests. Tell all of your health care providers and lab workers that you take this drug.
  • If you are 65 or older, use this drug with care. You could have more side effects.
  • Tell your doctor if you are breast-feeding. You will need to talk about any risks to your baby.

All injection products:

  • If you will be trying to get pregnant, it may take some time after your last dose of this drug to get pregnant. Talk with your doctor.

Cancer treatment:

  • Tell your doctor if you are pregnant or plan on getting pregnant. You will need to talk about the benefits and risks of using this drug while you are pregnant.

What are some side effects that I need to call my doctor about right away?

WARNING/CAUTION: Even though it may be rare, some people may have very bad and sometimes deadly side effects when taking a drug. Tell your doctor or get medical help right away if you have any of the following signs or symptoms that may be related to a very bad side effect:

All products:

  • Signs of an allergic reaction, like rash; hives; itching; red, swollen, blistered, or peeling skin with or without fever; wheezing; tightness in the chest or throat; trouble breathing or talking; unusual hoarseness; or swelling of the mouth, face, lips, tongue, or throat.
  • Signs of liver problems like dark urine, feeling tired, not hungry, upset stomach or stomach pain, light-colored stools, throwing up, or yellow skin or eyes.
  • Chest pain or pressure.
  • Shortness of breath.
  • Coughing up blood.
  • Weakness on 1 side of the body, trouble speaking or thinking, change in balance, or blurred eyesight.
  • Swelling, warmth, numbness, change of color, or pain in a leg or arm.
  • Very bad headache.
  • Very upset stomach or throwing up.
  • Very bad belly pain.
  • Very bad dizziness or passing out.
  • Bulging eyes.
  • Change in eyesight.
  • Change in how contact lenses feel in the eyes.
  • A lump in the breast, breast soreness, or nipple discharge.
  • Breast pain.
  • Vaginal itching or discharge.
  • Vaginal bleeding that is not normal.
  • Low mood (depression).
  • Mood changes.
  • Memory problems or loss.
  • Swelling in hands or feet.
  • Seizures.
  • Change in sex ability.


  • Very bad irritation where the shot was given.

What are some other side effects of this drug?

All drugs may cause side effects. However, many people have no side effects or only have minor side effects. Call your doctor or get medical help if any of these side effects or any other side effects bother you or do not go away:

All products:

  • Weight gain.
  • Headache.
  • Dizziness.
  • Feeling sleepy.
  • Upset stomach or throwing up.
  • Cramps.
  • Bloating.
  • Lowered interest in sex.
  • Pimples (acne).
  • Feeling tired or weak.
  • Enlarged breasts.
  • Vaginal bleeding or spotting.
  • Belly pain.
  • Leg cramps.
  • Swelling.
  • Not able to sleep.
  • This drug may cause dark patches of skin on your face. Avoid sun, sunlamps, and tanning beds. Use sunscreen and wear clothing and eyewear that protects you from the sun.


  • Period (menstrual) changes. These include lots of bleeding, spotting, or bleeding between cycles.
  • Period (menstrual) changes. Periods become less often or stop.
  • Irritation where the shot is given.
These are not all of the side effects that may occur. If you have questions about side effects, call your doctor. Call your doctor for medical advice about side effects.
You may report side effects to your national health agency.

How is this drug best taken?

Use this drug as ordered by your doctor. Read all information given to you. Follow all instructions closely.


  • Take tablet with or without food. Take with food if it causes an upset stomach.
  • Take this drug at the same time of day.

Injection (if given in the muscle):

  • It is given as a shot into a muscle.

Shot (if given under the skin):

  • It is given as a shot into the fatty part of the skin.

What do I do if I miss a dose?


  • Take a missed dose as soon as you think about it.
  • If it is close to the time for your next dose, skip the missed dose and go back to your normal time.
  • Do not take 2 doses at the same time or extra doses.


  • Call your doctor to find out what to do.

How do I store and/or throw out this drug?


  • Store at room temperature.
  • Store in a dry place. Do not store in a bathroom.


  • Most of the time, this drug will be given in a hospital or doctor’s office. If stored at home, follow how to store as you were told by the doctor.

All products:

  • Keep all drugs in a safe place. Keep all drugs out of the reach of children and pets.
  • Check with your pharmacist about how to throw out unused drugs.

General drug facts

  • If your symptoms or health problems do not get better or if they become worse, call your doctor.
  • Do not share your drugs with others and do not take anyone else’s drugs.
  • Keep a list of all your drugs (prescription, natural products, vitamins, OTC) with you. Give this list to your doctor.
  • Talk with the doctor before starting any new drug, including prescription or OTC, natural products, or vitamins.
  • Some drugs may have another patient information leaflet. If you have any questions about this drug, please talk with your doctor, nurse, pharmacist, or other health care provider.
  • If you think there has been an overdose, call your poison control center or get medical care right away. Be ready to tell or show what was taken, how much, and when it happened.

Consumer Information Use and Disclaimer

This information should not be used to decide whether or not to take this medicine or any other medicine. Only the healthcare provider has the knowledge and training to decide which medicines are right for a specific patient. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about this medicine. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to this medicine. This information is not specific medical advice and does not replace information you receive from the healthcare provider. You must talk with the healthcare provider for complete information about the risks and benefits of using this medicine.

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