Metronidazole (Topical)

Adult Medication

Brand Names: US

MetroCream; Metrogel; MetroGel-Vaginal; MetroLotion; Noritate; Nuvessa; Rosadan; Vandazole; Vitazol [DSC]

Brand Names: Canada

MetroCream; Metrogel; MetroLotion; Nidagel; Noritate; Rosasol

What is this drug used for?

  • It is used to treat rosacea.
  • It is used to treat vaginal infections.
  • It may be given to you for other reasons. Talk with the doctor.

What do I need to tell my doctor BEFORE I take this drug?

All products:

  • If you have an allergy to metronidazole or any other part of this drug.
  • If you are allergic to any drugs like this one, any other drugs, foods, or other substances. Tell your doctor about the allergy and what signs you had, like rash; hives; itching; shortness of breath; wheezing; cough; swelling of face, lips, tongue, or throat; or any other signs.


  • If you have taken disulfiram within the past 2 weeks.
This is not a list of all drugs or health problems that interact with this drug.
Tell your doctor and pharmacist about all of your drugs (prescription or OTC, natural products, vitamins) and health problems. You must check to make sure that it is safe for you to take this drug with all of your drugs and health problems. Do not start, stop, or change the dose of any drug without checking with your doctor.

What are some things I need to know or do while I take this drug?

All products:

  • Tell all of your health care providers that you take this drug. This includes your doctors, nurses, pharmacists, and dentists.
  • Talk with your doctor before you drink alcohol. You may need to avoid drinking alcohol while using this drug and for some time after your last dose.
  • Tell your doctor if you are pregnant or plan on getting pregnant. You will need to talk about the benefits and risks of using this drug while you are pregnant.
  • Tell your doctor if you are breast-feeding. You will need to talk about any risks to your baby.


  • Do not douche or use other vaginal products like tampons while you are using this drug. You may need to avoid these things for some time after care ends. Talk with your doctor.
  • This drug may affect certain lab tests. Be sure your doctor and lab workers know you use this drug.

What are some side effects that I need to call my doctor about right away?

WARNING/CAUTION: Even though it may be rare, some people may have very bad and sometimes deadly side effects when taking a drug. Tell your doctor or get medical help right away if you have any of the following signs or symptoms that may be related to a very bad side effect:

All products:

  • Signs of an allergic reaction, like rash; hives; itching; red, swollen, blistered, or peeling skin with or without fever; wheezing; tightness in the chest or throat; trouble breathing or talking; unusual hoarseness; or swelling of the mouth, face, lips, tongue, or throat.
  • A burning, numbness, or tingling feeling that is not normal.
  • Seizures.

All skin products:

  • Very bad skin irritation.


  • Very bad vaginal irritation.
  • Vaginal discharge.

What are some other side effects of this drug?

All drugs may cause side effects. However, many people have no side effects or only have minor side effects. Call your doctor or get medical help if any of these side effects or any other side effects bother you or do not go away:

All skin products:

  • Skin irritation.
  • Dry skin.
  • Scaling.
  • Itching.
  • Stinging.
  • Burning.


  • Irritation where this drug is used.
  • Loose stools (diarrhea).
  • Headache.
  • Upset stomach.
  • Period (menstrual) pain.
These are not all of the side effects that may occur. If you have questions about side effects, call your doctor. Call your doctor for medical advice about side effects.
You may report side effects to your national health agency.

How is this drug best taken?

Use this drug as ordered by your doctor. Read all information given to you. Follow all instructions closely.

All products:

  • Follow how to take this drug as you have been told by your doctor. Do not use more than you were told to use.
  • Wash your hands before and after use.
  • To gain the most benefit, do not miss doses.
  • Use as you have been told, even if your signs get better.

All skin products:

  • Do not take this drug by mouth. Use on your skin only. Keep out of your mouth, nose, and eyes (may burn).
  • Clean affected part before use. Make sure to dry well.
  • Put a thin layer on the affected skin and rub in gently.
  • Makeup may be used after the skin has dried.
  • Talk with your doctor before you use other drugs or products on your skin.


  • Do not take this drug by mouth. For vaginal use only. Keep out of your mouth, nose, and eyes (may burn).
  • Some products are to be used at bedtime. For some products it does not matter. Check with the pharmacist about how to use this drug.
  • Do not have vaginal sex while using this drug.
  • Do not use longer than you have been told. A second infection may happen.

What do I do if I miss a dose?

  • Use a missed dose as soon as you think about it.
  • If it is close to the time for your next dose, skip the missed dose and go back to your normal time.
  • Do not use 2 doses or extra doses.

How do I store and/or throw out this drug?

All skin products:

  • Store at room temperature.


  • Store at room temperature. Do not refrigerate or freeze.

All products:

  • Keep all drugs in a safe place. Keep all drugs out of the reach of children and pets.
  • Check with your pharmacist about how to throw out unused drugs.

General drug facts

  • If your symptoms or health problems do not get better or if they become worse, call your doctor.
  • Do not share your drugs with others and do not take anyone else’s drugs.
  • Keep a list of all your drugs (prescription, natural products, vitamins, OTC) with you. Give this list to your doctor.
  • Talk with the doctor before starting any new drug, including prescription or OTC, natural products, or vitamins.
  • Some drugs may have another patient information leaflet. If you have any questions about this drug, please talk with your doctor, nurse, pharmacist, or other health care provider.
  • If you think there has been an overdose, call your poison control center or get medical care right away. Be ready to tell or show what was taken, how much, and when it happened.

Consumer Information Use and Disclaimer

This information should not be used to decide whether or not to take this medicine or any other medicine. Only the healthcare provider has the knowledge and training to decide which medicines are right for a specific patient. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about this medicine. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to this medicine. This information is not specific medical advice and does not replace information you receive from the healthcare provider. You must talk with the healthcare provider for complete information about the risks and benefits of using this medicine.

Last Reviewed Date



© 2016 Wolters Kluwer Clinical Drug Information, Inc. and its affiliates and/or licensors. All rights reserved.