This information from Lexicomp® explains what you need to know about this medication, including what it’s used for, how to take it, its side effects, and when to call your healthcare provider.
Naloxone Hydrochloride Injection; Naloxone Hydrochloride Injection USP
- It is used to avoid side effects from some drugs.
- It is used to treat some overdoses.
- It may be given to you for other reasons. Talk with the doctor.
- If you have an allergy to naloxone or any other part of this drug.
- If you are allergic to any drugs like this one, any other drugs, foods, or other substances. Tell your doctor about the allergy and what signs you had, like rash; hives; itching; shortness of breath; wheezing; cough; swelling of face, lips, tongue, or throat; or any other signs.
This drug may interact with other drugs or health problems.
Tell your doctor and pharmacist about all of your drugs (prescription or OTC, natural products, vitamins) and health problems. You must check to make sure that it is safe for you to take this drug with all of your drugs and health problems. Do not start, stop, or change the dose of any drug without checking with your doctor.
- Tell all of your health care providers that you take this drug. This includes your doctors, nurses, pharmacists, and dentists.
- If you are addicted to pain drugs and are given this drug, you may have signs of withdrawal. Talk with your doctor.
- In infants younger than 4 weeks old who have been getting opioid drugs on a regular basis, sudden withdrawal may be life-threatening if not treated right away. Get medical help right away if your child has a seizure, is crying more than normal, or has increased reflexes.
- Tell your doctor if you are pregnant or plan on getting pregnant. You will need to talk about the benefits and risks of using this drug while you are pregnant.
- If this drug is used during pregnancy, it may cause withdrawal in the unborn baby. A doctor will need to check on the unborn baby after this drug is used.
- Tell your doctor if you are breast-feeding. You will need to talk about any risks to your baby.
Nose spray and auto-injector shot:
- After using this drug, overdose symptoms may go away and come back. It is important to get medical help right away after using this drug.
- Very bad side effects have happened when this drug has been given after surgery. This includes high or low blood pressure, abnormal heartbeats, and certain lung or heart problems. Sometimes, these side effects have led to brain problems, coma, and death. Talk with the doctor.
WARNING/CAUTION: Even though it may be rare, some people may have very bad and sometimes deadly side effects when taking a drug. Tell your doctor or get medical help right away if you have any of the following signs or symptoms that may be related to a very bad side effect:
- Signs of an allergic reaction, like rash; hives; itching; red, swollen, blistered, or peeling skin with or without fever; wheezing; tightness in the chest or throat; trouble breathing, swallowing, or talking; unusual hoarseness; or swelling of the mouth, face, lips, tongue, or throat.
- Signs of high or low blood pressure like very bad headache or dizziness, passing out, or change in eyesight.
- Shortness of breath.
- Chest pain or pressure or a fast heartbeat.
- A heartbeat that does not feel normal.
- A burning, numbness, or tingling feeling that is not normal.
- Feeling agitated.
- Mood changes.
- Hallucinations (seeing or hearing things that are not there).
- Sweating a lot.
All drugs may cause side effects. However, many people have no side effects or only have minor side effects. Call your doctor or get medical help if any of these side effects or any other side effects bother you or do not go away:
- Muscle pain.
- Muscle spasm.
- Dry nose.
- Stuffy nose.
- Runny nose.
- Swelling in the nose.
- Tooth pain.
- Dry skin.
All injection products:
- Upset stomach or throwing up.
- Irritation where the shot is given.
- Hot flashes.
These are not all of the side effects that may occur. If you have questions about side effects, call your doctor. Call your doctor for medical advice about side effects.
You may report side effects to your national health agency.
Use this drug as ordered by your doctor. Read all information given to you. Follow all instructions closely.
Nose spray and auto-injector shot:
- Follow how to use as you have been told by the doctor or read the package insert.
- Be sure you know how to use before an emergency happens. Read the package insert and instructions for use that come with this drug. If you have any questions about how to use this drug, talk with the doctor or pharmacist.
- Someone else may have to give this drug. Be sure others know where this drug is stored and how to give it if needed.
- Get medical help right away after using this drug.
- Do not use if this drug is out of date. Get a new one.
- For the nose only.
- Your doctor will teach you how to take this drug.
- Each nasal spray has only 1 dose and cannot be reused. If another dose is needed, you will need to use new nasal spray.
- If using more than 1 dose, switch nostrils with each dose.
- It is given as a shot into a muscle or into the fatty part of the skin.
- If you will be giving yourself the shot, your doctor or nurse will teach you how to give the shot.
- Jab straight into the outer thigh as you have been told. This drug may be given through clothes if needed. Inject and hold for as long as you were told.
- Do not use this drug if the solution changes color, is cloudy, or has particles. Get a new one.
- Each auto-injector has only 1 dose. If another dose is needed, you will need to use a second auto-injector.
All other injection products:
- It is given as a shot into a muscle, vein, or into the fatty part of the skin.
- Get medical help right away.
- Store in the original container at room temperature.
- Do not freeze.
- Protect from light.
- Store at room temperature. Do not freeze.
- Store in the case you were given.
All other injection products:
- If you need to store this drug at home, talk with your doctor, nurse, or pharmacist about how to store it.
- Keep all drugs in a safe place. Keep all drugs out of the reach of children and pets.
- Throw away unused or expired drugs. Do not flush down a toilet or pour down a drain unless you are told to do so. Check with your pharmacist if you have questions about the best way to throw out drugs. There may be drug take-back programs in your area.
- If your symptoms or health problems do not get better or if they become worse, call your doctor.
- Do not share your drugs with others and do not take anyone else’s drugs.
- Keep a list of all your drugs (prescription, natural products, vitamins, OTC) with you. Give this list to your doctor.
- Talk with the doctor before starting any new drug, including prescription or OTC, natural products, or vitamins.
- Some drugs may have another patient information leaflet. If you have any questions about this drug, please talk with your doctor, nurse, pharmacist, or other health care provider.
- If you think there has been an overdose, call your poison control center or get medical care right away. Be ready to tell or show what was taken, how much, and when it happened.
This information should not be used to decide whether or not to take this medicine or any other medicine. Only the healthcare provider has the knowledge and training to decide which medicines are right for a specific patient. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about this medicine. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to this medicine. This information is not specific medical advice and does not replace information you receive from the healthcare provider. You must talk with the healthcare provider for complete information about the risks and benefits of using this medicine.
© 2019 Wolters Kluwer Clinical Drug Information, Inc. and its affiliates and/or licensors. All rights reserved.