- It is used to treat hereditary tyrosinemia type 1 (HT-1).
- If you have an allergy to nitisinone or any other part of this drug.
- If you are allergic to any drugs like this one, any other drugs, foods, or other substances. Tell your doctor about the allergy and what signs you had, like rash; hives; itching; shortness of breath; wheezing; cough; swelling of face, lips, tongue, or throat; or any other signs.
- Tell all of your health care providers that you take this drug. This includes your doctors, nurses, pharmacists, and dentists.
- Have blood work checked as you have been told by the doctor. Talk with the doctor.
- Have your urine checked as you have been told by your doctor.
- Have an eye exam as you have been told by your doctor.
- Nitisinone must be used with a special diet that is low in tyrosine and phenylalanine.
- Follow the diet plan that your doctor told you about.
- Tell your doctor if you are pregnant or plan on getting pregnant. You will need to talk about the benefits and risks of using this drug while you are pregnant.
- Tell your doctor if you are breast-feeding. You will need to talk about any risks to your baby.
- Signs of an allergic reaction, like rash; hives; itching; red, swollen, blistered, or peeling skin with or without fever; wheezing; tightness in the chest or throat; trouble breathing, swallowing, or talking; unusual hoarseness; or swelling of the mouth, face, lips, tongue, or throat.
- Signs of liver problems like dark urine, feeling tired, not hungry, upset stomach or stomach pain, light-colored stools, throwing up, or yellow skin or eyes.
- Change in skin on hands or feet.
- Change in eyesight, eye pain, or very bad eye irritation.
- Eye is bothered by bright light.
- Feeling confused.
- Fever or chills.
- Sore throat.
- Any unexplained bruising or bleeding.
- Upset stomach.
- Loose stools (diarrhea).
- To gain the most benefit, do not miss doses.
- Keep taking this drug as you have been told by your doctor or other health care provider, even if you feel well.
- Take on an empty stomach. Take 1 hour before or 2 hours after meals.
- Capsules may be opened and contents mixed with a small amount of water, formula, or applesauce.
- If mixed, swallow the mixed drug right away. Do not store for use at a later time.
- Take with or without food.
- If you cannot swallow this drug whole, you may melt it in room temperature water in an oral syringe. If you can swallow soft foods, the tablets can be crushed and mixed with applesauce. Do not mix with other liquids or foods. Follow how to mix as you have been told by your doctor or read the package insert.
- Wash your hands before use.
- Take within 2 hours of mixing. Do not store for future use.
- If the adapter has not been put in the bottle when you get it, follow how to prepare the bottle as you have been told or read the package insert.
- Take with or without food.
- Shake well before use.
- Measure liquid doses carefully. Use the measuring device that comes with this drug. If there is none, ask the pharmacist for a device to measure this drug.
- Take a missed dose as soon as you think about it.
- If it is close to the time for your next dose, skip the missed dose and go back to your normal time.
- Do not take 2 doses at the same time or extra doses.
- Store in a refrigerator. Do not freeze.
- Store in the original container at room temperature.
- Keep lid tightly closed.
- Store in a dry place. Do not store in a bathroom.
- If you have mixed this drug with water or in applesauce, keep it out of sunlight.
- If the adapter has not been put in the bottle when you get it, store in a refrigerator until you need to prepare the bottle.
- Do not freeze.
- After the adapter has been put in the bottle, store at room temperature.
- Throw away any unused part 60 days after the adapter was put in the bottle. You or your pharmacist will need to write the date to throw away on the bottle label.
- Keep all drugs in a safe place. Keep all drugs out of the reach of children and pets.
- Throw away unused or expired drugs. Do not flush down a toilet or pour down a drain unless you are told to do so. Check with your pharmacist if you have questions about the best way to throw out drugs. There may be drug take-back programs in your area.
- If your symptoms or health problems do not get better or if they become worse, call your doctor.
- Do not share your drugs with others and do not take anyone else’s drugs.
- Keep a list of all your drugs (prescription, natural products, vitamins, OTC) with you. Give this list to your doctor.
- Talk with the doctor before starting any new drug, including prescription or OTC, natural products, or vitamins.
- Some drugs may have another patient information leaflet. If you have any questions about this drug, please talk with your doctor, nurse, pharmacist, or other health care provider.
- If you think there has been an overdose, call your poison control center or get medical care right away. Be ready to tell or show what was taken, how much, and when it happened.