- It is used to treat hereditary tyrosinemia type 1 (HT-1).
- If your child has an allergy to this drug or any part of this drug.
- If your child is allergic to any drugs like this one or any other drugs, foods, or other substances. Tell the doctor about the allergy and what signs your child had, like rash; hives; itching; shortness of breath; wheezing; cough; swelling of face, lips, tongue, or throat; or any other signs.
- Tell all of your child’s health care providers that your child is taking this drug. This includes your child’s doctors, nurses, pharmacists, and dentists.
- Have your child’s blood work checked often. Talk with your child’s doctor.
- Get your child an eye exam as you have been told by the doctor.
- Nitisinone must be used with a special diet that is low in tyrosine and phenylalanine.
- Have your child follow the diet plan your child’s doctor told you about.
If your child is pregnant or breast-feeding a baby:
- Talk with the doctor if your child is pregnant, becomes pregnant, or is breast-feeding a baby. You will need to talk about the benefits and risks of using this drug.
- Signs of an allergic reaction, like rash; hives; itching; red, swollen, blistered, or peeling skin with or without fever; wheezing; tightness in the chest or throat; trouble breathing or talking; unusual hoarseness; or swelling of the mouth, face, lips, tongue, or throat.
- Signs of liver problems like dark urine, feeling tired, not hungry, upset stomach or stomach pain, light-colored stools, throwing up, or yellow skin or eyes.
- Change in skin on hands or feet.
- Change in eyesight, eye pain, or very bad eye irritation.
- Eye is bothered by bright light.
- Feeling confused.
- Fever or chills.
- Sore throat.
- Any unexplained bruising or bleeding.
- Upset stomach.
- Loose stools (diarrhea).
- Give on an empty stomach. Give 1 hour before or 2 hours after meals.
- Capsules may be opened and contents mixed with a small amount of water, formula, or applesauce.
- If mixed, have your child swallow the mixed drug right away. Do not store for use at a later time.
- If the adapter has not been put in the bottle when you get it, follow how to prepare the bottle as you have been told or read the package insert.
- Give this drug with or without food.
- Shake well before use.
- Measure liquid doses carefully. Use the measuring device that comes with this drug. If there is none, ask the pharmacist for a device to measure this drug.
- To gain the most benefit, do not miss giving your child doses.
- Keep giving this drug to your child as you have been told by your child’s doctor or other health care provider, even if your child feels well.
- Give a missed dose as soon as you think about it.
- If it is close to the time for your child’s next dose, skip the missed dose and go back to your child’s normal time.
- Do not give 2 doses at the same time or extra doses.
- Store in a refrigerator. Do not freeze.
- If needed, you may store at room temperature for up to 45 days. If stored at room temperature and not used within 45 days, throw this drug away.
- If the adapter has not been put in the bottle when you get it, store in a refrigerator until you need to prepare the bottle.
- Do not freeze.
- After the adapter has been put in the bottle, store at room temperature.
- Throw away any unused part 60 days after the adapter was put in the bottle. You or your pharmacist will need to write the date to throw away on the bottle label.
- Keep all drugs in a safe place. Keep all drugs out of the reach of children and pets.
- Check with your pharmacist about how to throw out unused drugs.
- If your child’s symptoms or health problems do not get better or if they become worse, call your child’s doctor.
- Do not share your child’s drug with others and do not give anyone else’s drug to your child.
- Keep a list of all your child’s drugs (prescription, natural products, vitamins, OTC) with you. Give this list to your child’s doctor.
- Talk with your child’s doctor before giving your child any new drug, including prescription or OTC, natural products, or vitamins.
- Some drugs may have another patient information leaflet. If you have any questions about this drug, please talk with your child’s doctor, nurse, pharmacist, or other health care provider.
- If you think there has been an overdose, call your poison control center or get medical care right away. Be ready to tell or show what was taken, how much, and when it happened.