- If you have had hepatitis B before or carry the virus, this drug can cause the virus to become active. This can lead to very bad and sometimes deadly liver problems. You will be tested for hepatitis B before starting this drug, while on this drug, and for a few months after this drug is stopped. Do not take this drug if you have active hepatitis liver disease.
- A very bad brain problem called progressive multifocal leukoencephalopathy (PML) may happen with this drug. It may cause disability or death. Tell your doctor right away if you have signs like confusion, memory problems, low mood (depression), change in the way you act, change in strength on 1 side is greater than the other, trouble speaking or thinking, change in balance, or change in eyesight.
- It is used to treat a type of leukemia.
- If you have an allergy to obinutuzumab or any other part of this drug.
- If you are allergic to any drugs like this one, any other drugs, foods, or other substances. Tell your doctor about the allergy and what signs you had, like rash; hives; itching; shortness of breath; wheezing; cough; swelling of face, lips, tongue, or throat; or any other signs.
- If you have an infection.
- Tell dentists, surgeons, and other doctors that you use this drug.
- Very bad and sometimes deadly side effects have rarely happened during and within 24 hours after the infusion. Tell your doctor if you have any bad effects during or within 24 hours after the infusion.
- You may have more chance of getting an infection. Wash hands often. Stay away from people with infections, colds, or flu.
- Very bad and sometimes deadly infections have happened in patients who take this drug. If you have any infection, are taking antibiotics now or in the recent past, or have had many infections, talk with your doctor.
- You may bleed more easily. Be careful and avoid injury. Use a soft toothbrush and an electric razor.
- Very bad and sometimes deadly bleeding problems have happened with this drug. Talk with the doctor.
- Have blood work checked as you have been told by the doctor. Talk with the doctor.
- Talk with your doctor before getting any vaccines. Use with this drug may either raise the chance of an infection or make the vaccine not work as well.
- Heart problems have gotten worse in some people taking this drug. Sometimes this has been deadly. If you have heart problems, talk with your doctor.
- Tell your doctor if you are pregnant or plan on getting pregnant. You will need to talk about the benefits and risks of using this drug while you are pregnant.
- If you used this drug during pregnancy, tell your baby’s doctor. You will need to discuss the safety and timing of certain vaccines with the doctor.
- Tell your doctor if you are breast-feeding. You will need to talk about any risks to your baby.
- Signs of an allergic reaction, like rash; hives; itching; red, swollen, blistered, or peeling skin with or without fever; wheezing; tightness in the chest or throat; trouble breathing or talking; unusual hoarseness; or swelling of the mouth, face, lips, tongue, or throat.
- Signs of infection like fever, chills, very bad sore throat, ear or sinus pain, cough, more sputum or change in color of sputum, pain with passing urine, mouth sores, or wound that will not heal.
- Signs of bleeding like throwing up blood or throw up that looks like coffee grounds; coughing up blood; blood in the urine; black, red, or tarry stools; bleeding from the gums; vaginal bleeding that is not normal; bruises without a reason or that get bigger; or any bleeding that is very bad or that you cannot stop.
- Signs of liver problems like dark urine, feeling tired, not hungry, upset stomach or stomach pain, light-colored stools, throwing up, or yellow skin or eyes.
- A fast heartbeat.
- Very bad headache.
- Feeling very tired or weak.
- Patients with cancer who take this drug may be at greater risk of getting a bad and sometimes deadly health problem called tumor lysis syndrome (TLS). Call your doctor right away if you have a fast heartbeat or a heartbeat that does not feel normal; any passing out; trouble passing urine; muscle weakness or cramps; upset stomach, throwing up, loose stools or not able to eat; or feel sluggish.
- Some people have side effects while getting this drug or within 24 hours after. Call your doctor right away if you have fever, chills, muscle or joint pain, flushing or swelling of the face, throwing up, weakness, shortness of breath, very bad dizziness or passing out, or chest pain or pressure.
- Loose stools (diarrhea).
- Muscle pain.
- Upset stomach.
- It is given as an infusion into a vein over a period of time.
- Other drugs may be given before this drug to help with infusion side effects.
- Call the doctor to find out what to do.
- This drug will be given to you in a hospital or doctor’s office. You will not store it at home.
- If your symptoms or health problems do not get better or if they become worse, call your doctor.
- Do not share your drugs with others and do not take anyone else’s drugs.
- Keep a list of all your drugs (prescription, natural products, vitamins, OTC) with you. Give this list to your doctor.
- Talk with the doctor before starting any new drug, including prescription or OTC, natural products, or vitamins.
- Keep all drugs out of the reach of children and pets.
- Check with your pharmacist about how to throw out unused drugs.
- Some drugs may have another patient information leaflet. If you have any questions about this drug, please talk with your doctor, pharmacist, or other health care provider.
- If you think there has been an overdose, call your poison control center or get medical care right away. Be ready to tell or show what was taken, how much, and when it happened.
If you have any questions or concerns, talk with a member of your healthcare team. You can reach them Monday through Friday from 9:00 am to 5:00 pm at ____________________. After 5:00 pm, during the weekend, and on holidays, please call____________________. If there’s no number listed, or you’re not sure, call
Obinutuzumab©2015 Memorial Sloan Kettering Cancer Center - Generated on October 9, 2015