Adult Medication

Brand Names: US

Creon; Pancreaze; Pancrelipase (Lip-Prot-Amyl); Pertzye; Ultresa; Viokace; Zenpep

Brand Names: Canada

Cotazym; Creon; Pancrease MT; Ultrase; Ultrase MT; Viokase

What is this drug used for?

  • It is used to help break down food when the pancreas is not working the right way.

What do I need to tell my doctor BEFORE I take this drug?

All products:

  • If you have an allergy to pancrelipase, pork, or any other part of this drug.
  • If you are allergic to any drugs like this one, any other drugs, foods, or other substances. Tell your doctor about the allergy and what signs you had, like rash; hives; itching; shortness of breath; wheezing; cough; swelling of face, lips, tongue, or throat; or any other signs.


  • If you are allergic to lactose, talk with the doctor.
This drug may interact with other drugs or health problems.
Tell your doctor and pharmacist about all of your drugs (prescription or OTC, natural products, vitamins) and health problems. You must check to make sure that it is safe for you to take this drug with all of your drugs and health problems. Do not start, stop, or change the dose of any drug without checking with your doctor.

What are some things I need to know or do while I take this drug?

  • Tell all of your health care providers that you take this drug. This includes your doctors, nurses, pharmacists, and dentists.
  • Have your blood work checked. Talk with your doctor.
  • Follow the diet plan that your doctor told you about.
  • If you have high blood sugar (diabetes), you will need to watch your blood sugar closely.
  • There is more than 1 brand of this drug. One brand cannot safely be used for the other. The doctor will tell you about any needed change.
  • Watch for gout attacks.
  • This drug is made from pork (pig) pancreas tissue. There is a very small risk of getting a viral disease from this drug. No cases have happened. Talk with the doctor.
  • Tell your doctor if you are pregnant or plan on getting pregnant. You will need to talk about the benefits and risks of using this drug while you are pregnant.
  • Tell your doctor if you are breast-feeding. You will need to talk about any risks to your baby.

What are some side effects that I need to call my doctor about right away?

WARNING/CAUTION: Even though it may be rare, some people may have very bad and sometimes deadly side effects when taking a drug. Tell your doctor or get medical help right away if you have any of the following signs or symptoms that may be related to a very bad side effect:
  • Signs of an allergic reaction, like rash; hives; itching; red, swollen, blistered, or peeling skin with or without fever; wheezing; tightness in the chest or throat; trouble breathing or talking; unusual hoarseness; or swelling of the mouth, face, lips, tongue, or throat.
  • Joint pain or swelling.
  • Mouth or tongue irritation.
  • This drug may raise the chance of a rare bowel problem called fibrosing colonopathy. This bowel problem can be very bad and may lead to the need for surgery. Call your doctor right away if you have any abnormal or very bad stomach pain, bloating, trouble passing stools, upset stomach, throwing up, or loose stools (diarrhea).

What are some other side effects of this drug?

All drugs may cause side effects. However, many people have no side effects or only have minor side effects. Call your doctor or get medical help if any of these side effects or any other side effects bother you or do not go away:
  • Belly pain.
  • Headache.
  • Gas.
  • Hard stools (constipation).
  • Cough.
  • Sore throat.
  • Loose stools (diarrhea).
  • Upset stomach or throwing up.
  • Neck pain.
  • Stuffy nose.
  • Ear pain.
  • Heartburn.
  • Dizziness.
  • Nosebleed.
These are not all of the side effects that may occur. If you have questions about side effects, call your doctor. Call your doctor for medical advice about side effects.
You may report side effects to your national health agency.

How is this drug best taken?

Use this drug as ordered by your doctor. Read all information given to you. Follow all instructions closely.

All products:

  • Take with meals and snacks.
  • Swallow whole. Do not chew, crush, or hold this product in your mouth. If you do, you may get mouth irritation or it may change the way this drug works. Talk with your doctor.
  • Take each dose with lots of fluids to make sure you swallow all of the contents.
  • Keep taking this drug as you have been told by your doctor or other health care provider, even if you feel well.
  • To gain the most benefit, do not miss doses.


  • You may sprinkle contents of capsule on applesauce. Do not chew. Swallow right away and follow with water or juice.
  • After mixing, take your dose right away. Do not store for future use.
  • Some products may be sprinkled on foods other than applesauce. Be sure you know what foods you can mix this drug with.
Infants up to 12 months old:
  • Give this drug every time you feed your child.
  • Sprinkle the contents into the infant’s mouth or over a small amount of applesauce. Some products may also be mixed with other foods found in baby food jars like bananas or pears. Be sure you know what foods you can mix this drug with.
  • Do not mix with baby formula or breast milk.
  • Give the mixture right away. Do not store for use at a later time.
  • Have your child drink baby formula or breast milk right after giving.
  • Check inside your child’s mouth after feeding to make sure your child swallowed the drug.

What do I do if I miss a dose?

  • Skip the missed dose and go back to your normal time.
  • Do not take 2 doses at the same time or extra doses.

How do I store and/or throw out this drug?

  • Store at room temperature.
  • Store in the original container. Do not take out the antimoisture cube or packet.
  • Keep lid tightly closed.
  • Protect from heat.
  • Store in a dry place. Do not store in a bathroom.
  • Keep all drugs in a safe place. Keep all drugs out of the reach of children and pets.
  • Check with your pharmacist about how to throw out unused drugs.

General drug facts

  • If your symptoms or health problems do not get better or if they become worse, call your doctor.
  • Do not share your drugs with others and do not take anyone else’s drugs.
  • Keep a list of all your drugs (prescription, natural products, vitamins, OTC) with you. Give this list to your doctor.
  • Talk with the doctor before starting any new drug, including prescription or OTC, natural products, or vitamins.
  • Some drugs may have another patient information leaflet. If you have any questions about this drug, please talk with your doctor, nurse, pharmacist, or other health care provider.
  • If you think there has been an overdose, call your poison control center or get medical care right away. Be ready to tell or show what was taken, how much, and when it happened.

Consumer Information Use and Disclaimer

This information should not be used to decide whether or not to take this medicine or any other medicine. Only the healthcare provider has the knowledge and training to decide which medicines are right for a specific patient. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about this medicine. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to this medicine. This information is not specific medical advice and does not replace information you receive from the healthcare provider. You must talk with the healthcare provider for complete information about the risks and benefits of using this medicine.

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