This information from Lexicomp® explains what you need to know about this medication, including what it’s used for, how to take it, its side effects, and when to call your healthcare provider.
Skyrizi; Skyrizi (150 MG Dose); Skyrizi Pen
- It is used to treat plaque psoriasis.
- It is used to treat psoriatic arthritis.
- It is used to treat Crohn’s disease.
- It may be given to you for other reasons. Talk with the doctor.
- If you are allergic to this drug; any part of this drug; or any other drugs, foods, or substances. Tell your doctor about the allergy and what signs you had.
- If you have an infection.
- If you have active TB (tuberculosis).
- If you have recently had a live vaccine.
This is not a list of all drugs or health problems that interact with this drug.
Tell your doctor and pharmacist about all of your drugs (prescription or OTC, natural products, vitamins) and health problems. You must check to make sure that it is safe for you to take this drug with all of your drugs and health problems. Do not start, stop, or change the dose of any drug without checking with your doctor.
- Tell all of your health care providers that you take this drug. This includes your doctors, nurses, pharmacists, and dentists.
- Have your blood work and other lab tests checked as you have been told by your doctor.
- You may have more chance of getting an infection. Wash hands often. Stay away from people with infections, colds, or flu.
- You will need a TB (tuberculosis) test before starting this drug.
- Make sure you are up to date with all your vaccines before treatment with this drug.
- Talk with your doctor before getting any vaccines right before you start this drug, while you take it, and right after you stop taking it. Vaccine use with this drug may either raise the chance of an infection or make the vaccine not work as well.
- Tell your doctor if you are pregnant, plan on getting pregnant, or are breast-feeding. You will need to talk about the benefits and risks to you and the baby.
- If you used this drug when you were pregnant, tell your baby’s doctor.
WARNING/CAUTION: Even though it may be rare, some people may have very bad and sometimes deadly side effects when taking a drug. Tell your doctor or get medical help right away if you have any of the following signs or symptoms that may be related to a very bad side effect:
- Signs of an allergic reaction, like rash; hives; itching; red, swollen, blistered, or peeling skin with or without fever; wheezing; tightness in the chest or throat; trouble breathing, swallowing, or talking; unusual hoarseness; or swelling of the mouth, face, lips, tongue, or throat.
- Signs of infection like fever, chills, very bad sore throat, ear or sinus pain, cough, more sputum or change in color of sputum, pain with passing urine, mouth sores, or wound that will not heal.
- Signs of liver problems like dark urine, feeling tired, not hungry, upset stomach or stomach pain, light-colored stools, throwing up, or yellow skin or eyes.
- Flu-like signs.
- Shortness of breath.
- Coughing up blood.
- Weight loss.
- Warm, red, or painful skin or sores on the body.
- Muscle aches.
- Passing urine more often.
- Severe diarrhea.
- Very bad belly pain.
All drugs may cause side effects. However, many people have no side effects or only have minor side effects. Call your doctor or get medical help if any of these side effects or any other side effects bother you or do not go away:
- Signs of a common cold.
- Feeling tired or weak.
- Irritation where the shot is given.
- Joint pain.
- Stomach pain.
These are not all of the side effects that may occur. If you have questions about side effects, call your doctor. Call your doctor for medical advice about side effects.
You may report side effects to your national health agency.
Use this drug as ordered by your doctor. Read all information given to you. Follow all instructions closely.
All subcutaneous products:
- It is given as a shot into the fatty part of the skin on the top of the thigh or the belly area.
- If you will be giving yourself the shot, your doctor or nurse will teach you how to give the shot.
- Take this drug out of the refrigerator and let it come to room temperature before you use it. Be sure you know how long to leave it at room temperature. Do not heat or microwave.
- Keep out of direct sunlight.
- Do not shake.
- Do not use this drug if it has been dropped or if it is broken.
- This product is clear but may contain small white or clear particles. You may also see one or more air bubbles. Do not use if the solution is cloudy, leaking, or has large particles.
- This drug is colorless to a faint yellow. Do not use if the solution changes color.
- Do not give into skin that is irritated, tender, bruised, red, scaly, hard, scarred, or has stretch marks.
- Do not give into skin that is affected by psoriasis.
- Do not give into skin within 2 inches of the belly button.
- Each container is for one use only. Use right after opening. Throw away any part of the opened container after the dose is given.
- Throw away needles in a needle/sharp disposal box. Do not reuse needles or other items. When the box is full, follow all local rules for getting rid of it. Talk with a doctor or pharmacist if you have any questions.
Prefilled syringes or pens:
- This drug may be given into the outer area of the upper arm if given by someone else.
- Do not remove the cap or cover until ready to use.
- Do not inject through clothes.
- If the dose is more than 1 injection, give the injections into 2 different places.
- Use this drug within 5 minutes after putting the cartridge in the on-body injector. Do not push the start button until the on-body injector is ready to use and is placed on the skin. This button can only be pushed 1 time.
- Do not give into a mole.
- Do not put on skin with a lot of hair.
- Do not use this product on an area of skin that folds or bulges.
- Do not get this product wet.
- It may take up to 5 minutes for the injection to finish. Limit physical activity while getting this drug. You can do things like walking, reaching, and bending.
- Keep electronic devices like cell phones at least 12 inches away from this product until the injection is done.
- It is given as an infusion into a vein over a period of time.
All subcutaneous products:
- Take a missed dose as soon as you think about it and go back to your normal time.
- Do not take 2 doses at the same time or extra doses.
- If you are not sure what to do if you miss a dose, call your doctor.
- Call your doctor to find out what to do.
All subcutaneous products:
- Store in a refrigerator. Do not freeze.
- Do not use if it has been frozen.
- Store in the original container to protect from light.
- If you need to store this drug at home, talk with your doctor, nurse, or pharmacist about how to store it.
- Keep all drugs in a safe place. Keep all drugs out of the reach of children and pets.
- Throw away unused or expired drugs. Do not flush down a toilet or pour down a drain unless you are told to do so. Check with your pharmacist if you have questions about the best way to throw out drugs. There may be drug take-back programs in your area.
- If your symptoms or health problems do not get better or if they become worse, call your doctor.
- Do not share your drugs with others and do not take anyone else’s drugs.
- Some drugs may have another patient information leaflet. If you have any questions about this drug, please talk with your doctor, nurse, pharmacist, or other health care provider.
- This drug comes with an extra patient fact sheet called a Medication Guide. Read it with care. Read it again each time this drug is refilled. If you have any questions about this drug, please talk with the doctor, pharmacist, or other health care provider.
- If you think there has been an overdose, call your poison control center or get medical care right away. Be ready to tell or show what was taken, how much, and when it happened.
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