Sirolimus (Topical)

Pediatric Medication
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This information from Lexicomp® explains what you need to know about this medication, including what it’s used for, how to take it, its side effects, and when to call your healthcare provider.

Brand Names: US

Hyftor

What is this drug used for?

  • It is used to treat a skin problem called angiofibroma.

What do I need to tell the doctor BEFORE my child takes this drug?

  • If your child is allergic to this drug; any part of this drug; or any other drugs, foods, or substances. Tell the doctor about the allergy and what signs your child had.

If your child is breast-feeding a baby:

  • Be sure your child does not breast-feed a baby while taking this drug.

This drug may interact with other drugs or health problems.

Tell the doctor and pharmacist about all of your child’s drugs (prescription or OTC, natural products, vitamins) and health problems. You must check to make sure that it is safe to give this drug with all of your child’s other drugs and health problems. Do not start, stop, or change the dose of any drug your child takes without checking with the doctor.

What are some things I need to know or do while my child takes this drug?

  • Tell all of your child’s health care providers that your child is taking this drug. This includes your child’s doctors, nurses, pharmacists, and dentists.
  • Talk with the doctor before your child gets any vaccines after getting this drug. Vaccine use after getting this drug may make the vaccine not work as well.
  • If possible, make sure all vaccines are up to date before treatment with this drug.
  • Have your child avoid sun, sunlamps, and tanning beds while using this drug. Have your child avoid these things even when this drug is not on the skin. Talk with the doctor about ways to protect your child’s skin from the sun.
  • Do not let your child have any kind of light therapy while using this drug.
  • This drug may affect fertility. Fertility problems may lead to not being able to get pregnant or father a child. If your child plans to get pregnant or father a child, talk with the doctor before your child takes this drug.

If your child is or may be sexually active:

  • This drug may cause harm to the unborn baby if your child takes it during pregnancy.
  • Have your child use birth control to prevent pregnancy during treatment and for some time after the last dose. Talk with the doctor to see how long your child needs to use birth control after stopping this drug.

What are some side effects that I need to call my child’s doctor about right away?

WARNING/CAUTION: Even though it may be rare, some people may have very bad and sometimes deadly side effects when taking a drug. Tell your child’s doctor or get medical help right away if your child has any of the following signs or symptoms that may be related to a very bad side effect:

  • Signs of an allergic reaction, like rash; hives; itching; red, swollen, blistered, or peeling skin with or without fever; wheezing; tightness in the chest or throat; trouble breathing, swallowing, or talking; unusual hoarseness; or swelling of the mouth, face, lips, tongue, or throat.
  • Chest pain.
  • Dizziness or passing out.
  • This drug also has forms that are taken by mouth. Severe and sometimes deadly effects have happened with these forms. These have included allergic reactions, high cholesterol, high triglyceride levels, lung problems, and infection (including a brain infection called PML). Rare cases of cancer like lymphoma or skin cancer have also happened. Talk with the doctor if you have any questions.
  • Call the doctor right away if your child has any signs of these effects. This may include confusion, memory problems, depression, behavior change, weakness, trouble speaking or thinking, change in balance, change in eyesight, cough, shortness of breath, or trouble breathing. It may also include a skin lump or growth; change in the color or size of a mole; weight loss; night sweats; swollen glands; or signs of infection like fever, chills, or sore throat.

What are some other side effects of this drug?

All drugs may cause side effects. However, many people have no side effects or only have minor side effects. Call your child’s doctor or get medical help if any of these side effects or any other side effects bother your child or do not go away:

  • Eye redness.
  • It is common to have skin irritation with this drug. Skin irritation may include dry skin, redness, itching, or acne. Call the doctor if your child has skin irritation that is severe, bothers your child, or does not go away.

These are not all of the side effects that may occur. If you have questions about side effects, call your child’s doctor. Call your child’s doctor for medical advice about side effects.

You may report side effects to your national health agency.

How is this drug best given?

Give this drug as ordered by your child’s doctor. Read all information given to you. Follow all instructions closely.

  • Do not give by mouth. Use on your child’s skin only. Keep out of your child’s mouth, nose, and eyes (may burn).
  • Do not put in the vagina.
  • Wash your hands before and after use.
  • Put a thin layer on the affected part and rub in gently.
  • Do not put on healthy skin.
  • Do not use coverings (bandages, dressings) unless told to do so by the doctor.

What do I do if my child misses a dose?

  • Put on a missed dose as soon as you think about it.
  • If it is close to the time for your child’s next dose, skip the missed dose and go back to your child’s normal time.
  • Do not put on 2 doses at the same time or extra doses.

How do I store and/or throw out this drug?

  • Store in a refrigerator. Do not freeze.
  • Protect from light.
  • Keep all drugs in a safe place. Keep all drugs out of the reach of children and pets.
  • Throw away unused or expired drugs. Do not flush down a toilet or pour down a drain unless you are told to do so. Check with your pharmacist if you have questions about the best way to throw out drugs. There may be drug take-back programs in your area.

General drug facts

  • If your child’s symptoms or health problems do not get better or if they become worse, call your child’s doctor.
  • Do not share your child’s drug with others and do not give anyone else’s drug to your child.
  • Some drugs may have another patient information leaflet. If you have any questions about this drug, please talk with your child’s doctor, nurse, pharmacist, or other health care provider.
  • If you think there has been an overdose, call your poison control center or get medical care right away. Be ready to tell or show what was taken, how much, and when it happened.

Consumer Information Use and Disclaimer

This generalized information is a limited summary of diagnosis, treatment, and/or medication information. It is not meant to be comprehensive and should be used as a tool to help the user understand and/or assess potential diagnostic and treatment options. It does NOT include all information about conditions, treatments, medications, side effects, or risks that may apply to a specific patient. It is not intended to be medical advice or a substitute for the medical advice, diagnosis, or treatment of a health care provider based on the health care provider’s examination and assessment of a patient’s specific and unique circumstances. Patients must speak with a health care provider for complete information about their health, medical questions, and treatment options, including any risks or benefits regarding use of medications. This information does not endorse any treatments or medications as safe, effective, or approved for treating a specific patient. UpToDate, Inc. and its affiliates disclaim any warranty or liability relating to this information or the use thereof. The use of this information is governed by the Terms of Use, available at https://www.wolterskluwer.com/en/know/clinical-effectiveness-terms.

Last Reviewed Date

2022-04-29

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Last Updated