Testosterone

Adult Medication

Brand Names: US

Androderm; AndroGel; AndroGel Pump; Aveed; Axiron; Depo-Testosterone; First-Testosterone; First-Testosterone MC; Fortesta; Natesto; Striant; Testim; Testopel; Vogelxo; Vogelxo Pump

Brand Names: Canada

Andriol; Androderm; AndroGel; Axiron; Delatestryl; Depo-Testosterone; Natesto; PMS-Testosterone; Taro-Testosterone; Testim

Warning

Testosterone undecanoate:

  • A very bad lung problem has happened with this drug. Allergic reactions have also happened with this drug. Sometimes, allergic reactions have been life-threatening. These reactions have happened while this drug was given and right after. These reactions can happen with any dose of this drug.
  • You will be watched closely by your doctor for 30 minutes after each dose. Call your doctor right away if you have chest pain, cough or the need to cough, dizziness, passing out, shortness of breath, sweating, or throat tightness.
  • You can only get this drug through the Aveed REMS Program.

Skin gel, skin solution:

  • Wash the site where the drug was used before it touches anyone else’s skin.
  • Do not let your skin that the gel or solution was used on touch any children’s or women’s skin. Cover treated part with clothes. Signs of puberty may happen in children.
  • If a woman or child touches the gel, she/he needs to wash the skin with soap and water.

What is this drug used for?

  • It is used to treat low testosterone levels.
  • It is used in certain children when puberty is delayed.
  • It is used to treat breast cancer in women.
  • It may be given to you for other reasons. Talk with the doctor.

What do I need to tell my doctor BEFORE I take this drug?

All products:

  • If you have an allergy to testosterone or any other part of this drug.
  • If you are allergic to any drugs like this one, any other drugs, foods, or other substances. Tell your doctor about the allergy and what signs you had, like rash; hives; itching; shortness of breath; wheezing; cough; swelling of face, lips, tongue, or throat; or any other signs.
  • If you are male and have breast or prostate cancer.
  • If you have any of these health problems: Heart disease, kidney disease, or liver disease.

Testosterone enanthate:

  • If you are pregnant or may be pregnant. Do not take this drug if you are pregnant.
  • If you are breast-feeding. Do not breast-feed while you take this drug.

All other products:

  • If you are a woman. This drug is not approved for use in women. If you are a woman using this drug, talk with your doctor if you are pregnant, plan on getting pregnant, or are breast-feeding.

All products other than injection:

  • If the patient is a child. Do not give this drug to a child.

Nose gel:

  • If you have problems with swelling of the lining of your nose like Sjogren’s syndrome.
  • If you have ever had any of these health problems: Broken nose within the past 6 months, nose or sinus problems, nose or sinus surgery, or broken nose that caused the inside of the nose to be crooked (deviated septum).
  • If you are using another drug in the nose.
This is not a list of all drugs or health problems that interact with this drug.
Tell your doctor and pharmacist about all of your drugs (prescription or OTC, natural products, vitamins) and health problems. You must check to make sure that it is safe for you to take this drug with all of your drugs and health problems. Do not start, stop, or change the dose of any drug without checking with your doctor.

What are some things I need to know or do while I take this drug?

All products:

  • Tell all of your health care providers that you take this drug. This includes your doctors, nurses, pharmacists, and dentists.
  • If you have high blood sugar (diabetes), you will need to watch your blood sugar closely.
  • There may be a higher chance of prostate cancer. Talk with the doctor.
  • High blood pressure has happened with drugs like this one. Have your blood pressure checked as you have been told by your doctor.
  • Treatment with this drug may lead to higher cholesterol and triglycerides. The effect of these changes on heart health is not known. Talk with the doctor.
  • Have blood work checked as you have been told by the doctor. Talk with the doctor.
  • This drug may raise the chance of blood clots, a stroke, or a heart attack. Talk with the doctor.
  • This drug may affect certain lab tests. Tell all of your health care providers and lab workers that you take this drug.
  • If you are taking warfarin, talk with your doctor. You may need to have your blood work checked more closely while you are taking it with this drug.
  • This drug is an anabolic steroid. Anabolic steroid drugs have been abused and misused before. Anabolic steroid abuse can lead to dependence and very bad health problems. These health problems include heart or blood vessel problems, stroke, liver problems, and mental or mood problems. Talk with the doctor.
  • If you are 65 or older, use this drug with care. You could have more side effects.
  • This drug is not approved for treating low testosterone levels caused by getting older. Talk with your doctor.
  • This drug may affect sperm in men. This may affect being able to father a child. Talk with the doctor.

Skin gel, skin solution:

  • Tell the doctor right away if a child or woman touches the gel or solution and has any bad effects. In children, these are forceful actions, enlarged sex organs, and early growth of pubic hair. In women, these are a deep voice, change in body hair, or pimples.
  • If a pregnant woman touches the gel or solution, call the doctor right away.

Nose gel:

  • If you have very bad nose problems like runny nose, stuffy nose, or postnasal drip, or if you have these problems and they do not go away, talk with your doctor. You may need to stop this drug or switch to another product.

Patch:

  • The patch may have metal. Take off the patch before an MRI.

Cheek tablet:

  • Be sure to inspect your gums where you put this drug on a regular basis. Talk with your doctor.

Testosterone undecanoate:

  • This drug is not approved for use in children. Talk with the doctor.
All other injection products:
  • Some drugs may be used in children. Use care if this drug is given to a child. Talk with the doctor to see if this drug may be used in children. Talk with the doctor if you have questions about giving this drug to a child.
  • Some products have benzyl alcohol. Do not give a product that has benzyl alcohol in it to a newborn. Talk with the doctor to see if this product has benzyl alcohol in it.
  • This drug may affect growth in children and teens in some cases. They may need regular growth checks. Talk with the doctor.

What are some side effects that I need to call my doctor about right away?

WARNING/CAUTION: Even though it may be rare, some people may have very bad and sometimes deadly side effects when taking a drug. Tell your doctor or get medical help right away if you have any of the following signs or symptoms that may be related to a very bad side effect:

All products:

  • Signs of an allergic reaction, like rash; hives; itching; red, swollen, blistered, or peeling skin with or without fever; wheezing; tightness in the chest or throat; trouble breathing or talking; unusual hoarseness; or swelling of the mouth, face, lips, tongue, or throat.
  • Signs of high blood pressure like very bad headache or dizziness, passing out, or change in eyesight.
  • Signs of high calcium levels like weakness, confusion, feeling tired, headache, upset stomach and throwing up, hard stools (constipation), or bone pain.
  • For males, erections (hard penis) that happen often or that last a long time.
  • Passing urine more often.
  • Trouble passing urine.
  • Passing urine in a weak stream or drips.
  • Not able to control passing urine.
  • Mood changes.
  • Low mood (depression).
  • Change in how you act.
  • Enlarged breasts.
  • Breast pain.
  • Shortness of breath, a big weight gain, swelling in the arms or legs.
  • Upset stomach or throwing up.
  • Trouble breathing when sleeping.
  • Feeling sleepy during the day.
  • Weakness on 1 side of the body, trouble speaking or thinking, change in balance, drooping on one side of the face, or blurred eyesight.
  • Change in color of skin.
  • Change in size or shape of testicles.
  • Very bad irritation where this drug is used.
  • If you have an enlarged prostate, your signs can get worse while you use this drug. Call your doctor if this happens to you.
  • Call your doctor right away if you have signs of a blood clot like chest pain or pressure; coughing up blood; shortness of breath; swelling, warmth, numbness, change of color, or pain in a leg or arm; or trouble speaking or swallowing.
  • Liver problems have happened with drugs like this one. Sometimes, this has been deadly. Call your doctor right away if you have signs of liver problems like dark urine, feeling tired, not hungry, upset stomach or stomach pain, light-colored stools, throwing up, or yellow skin or eyes.

Nose gel:

  • Nosebleed.
  • Dry nose.
  • Nose pain or irritation.
  • Runny nose.
  • Stuffy nose.
  • Nose scabs.
  • Sneezing.

Cheek tablet:

  • Gum changes.

Injection (when used in females):

  • For females, a deep voice, facial hair, pimples, or period changes.

What are some other side effects of this drug?

All drugs may cause side effects. However, many people have no side effects or only have minor side effects. Call your doctor or get medical help if any of these side effects or any other side effects bother you or do not go away:

All products:

  • Headache.
  • Pimples (acne).
  • Loose stools (diarrhea).
  • Emotional ups and downs.
  • Change in sex interest.
  • Change in sex ability.
  • Feeling tired or weak.
  • Not able to sleep.
  • Irritation where this drug is used.

Nose gel:

  • Cough.
  • Throat irritation.

Cheek tablet:

  • Change in taste.
  • Bad taste in your mouth.

Patch:

  • Back pain.

All injection products:

  • Pain where the shot was given.
These are not all of the side effects that may occur. If you have questions about side effects, call your doctor. Call your doctor for medical advice about side effects.
You may report side effects to your national health agency.

How is this drug best taken?

Use this drug as ordered by your doctor. Read all information given to you. Follow all instructions closely.

All products:

  • Wash your hands before and after use.

Skin gel, skin solution:

  • Not all products are the same strength. Read and follow label carefully.
  • Do not get this drug on other parts of your body or on other people.
  • Do not put on the genitals.
  • Keep out of your eyes.
  • Some products come in pumps. Some products come in packets. If you are using a pump, you will need to prime it before you use it the first time. Prime the pump as you are told in the package insert.
  • Put on clean, dry, healthy skin.
  • Certain products are to be put on certain parts of the body. Be sure you know where to put this drug. Read the package insert for more details.
  • After putting this drug on, you will need to wait some time before you bathe, shower, or swim. Be sure you know how long you need to wait. Read the package insert for more details.
  • Let dry before covering with clothing.
  • Avoid fire, flames, or smoking until dry.

Skin solution:

  • Put on clean, dry, healthy skin using the applicator under the arm.
  • Do not use your fingers or hand to rub this drug into the skin.
  • Change armpits with each dose.
  • Allow skin to dry between uses.
  • If you use deodorant, put on at least 2 minutes before you put on this drug.

Nose gel:

  • Do not take this drug by mouth. Use in your nose only. Keep out of your mouth and eyes (may burn).
  • If you get this drug on the skin, wash it off right away with soap and water.
  • Use this drug at the same time of day.
  • You will need to prime the pump before first use. Do this by turning it upside down and pressing down on the pump 10 times. If any drug comes out during priming, wash down the sink with warm water.
  • Blow your nose before use.
  • Follow how to use as you have been told by the doctor or read the package insert.
  • Do not blow your nose or sniff for 1 hour after using this drug.
  • Follow how to clean carefully.

Patch:

  • Do not use patches that are cut or do not look right.
  • Put patch on clean, dry, healthy skin on back, belly, thigh, or upper arm.
  • Do not put on an area that is bony. Do not put on an area that will have pressure on it for a long time while sleeping or sitting.
  • Do not put on the genitals.
  • Put on a new patch at the same time every night. Be sure to take off the old patch before you put on the new one.
  • Move the patch site with each new patch. Do not put on the same site for 7 days.
  • Do not bathe, shower, or swim for 3 hours after putting on.
  • Do not cover the patch with other bandages or tape. If the patch does not stick well, talk with your doctor or pharmacist.
  • If your patch falls off before noon, put on a new patch and wear it until you put on a new patch at your normal time.
  • If your patch falls off after noon, do not put on a new one. Wait and put on a new patch at your normal time.
  • After you take off a skin patch, be sure to fold the sticky sides of the patch to each other.

Cheek tablet:

  • Do not take this drug out of the blister pack until you are ready to take it. Take this drug right away after opening the blister pack. Do not store the removed drug for future use.
  • Dry your hands and place the tablet in your mouth above the incisor tooth between the upper cheek and gum. Let it melt during the day.
  • Do not chew or swallow.
  • Change the side of mouth with each dose.
  • Do not take out until it is time for your next dose.
  • Make sure drug is still in place after eating, drinking, brushing your teeth, or using mouthwash.
  • If the drug does not stick or falls out, follow what your doctor has told you or read the package insert. If you are not sure what to do, talk with your doctor.
  • To remove tablet, gently slide it down from the gum toward the tooth to keep from scratching the gum.

All injection products:

  • It is given as a shot into a muscle.

Testosterone undecanoate:

  • Your doctor will give this drug.
All other injection products:
  • If you will be giving yourself the shot, your doctor or nurse will teach you how to give the shot.
  • Follow how to use as you have been told by the doctor or read the package insert.
  • Do not use if the solution is cloudy, leaking, or has particles.
  • Do not use if solution changes color.
  • Throw away needles in a needle/sharp disposal box. Do not reuse needles or other items. When the box is full, follow all local rules for getting rid of it. Talk with a doctor or pharmacist if you have any questions.

What do I do if I miss a dose?

Testosterone undecanoate:

  • Call your doctor to find out what to do.

All other products:

  • Use a missed dose as soon as you think about it.
  • If it is close to the time for your next dose, skip the missed dose and go back to your normal time.
  • Do not use 2 doses or extra doses.

How do I store and/or throw out this drug?

All products other than injection:

  • Store at room temperature. Do not freeze.
  • Store in a dry place. Do not store in a bathroom.

Skin gel, skin solution:

  • Protect from heat or open flame.

Cheek tablet:

  • Protect from heat.

Patch:

  • Store in pouch until ready for use.

Injection:

  • If you need to store this drug at home, talk with your doctor, nurse, or pharmacist about how to store it.

All products:

  • Keep all drugs in a safe place. Keep all drugs out of the reach of children and pets.
  • Check with your pharmacist about how to throw out unused drugs.

General drug facts

  • If your symptoms or health problems do not get better or if they become worse, call your doctor.
  • Do not share your drugs with others and do not take anyone else’s drugs.
  • Keep a list of all your drugs (prescription, natural products, vitamins, OTC) with you. Give this list to your doctor.
  • Talk with the doctor before starting any new drug, including prescription or OTC, natural products, or vitamins.
  • Some drugs may have another patient information leaflet. If you have any questions about this drug, please talk with your doctor, nurse, pharmacist, or other health care provider.
  • If you think there has been an overdose, call your poison control center or get medical care right away. Be ready to tell or show what was taken, how much, and when it happened.

Consumer Information Use and Disclaimer

This information should not be used to decide whether or not to take this medicine or any other medicine. Only the healthcare provider has the knowledge and training to decide which medicines are right for a specific patient. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about this medicine. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to this medicine. This information is not specific medical advice and does not replace information you receive from the healthcare provider. You must talk with the healthcare provider for complete information about the risks and benefits of using this medicine.

Last Reviewed Date

2016-11-03

Copyright

© 2016 Wolters Kluwer Clinical Drug Information, Inc. and its affiliates and/or licensors. All rights reserved.