The purpose of this study is to evaluate the effectiveness of a vaccine to delay or prevent recurrence of disease in patients with malignant pleural mesothelioma that has been surgically removed and treated with chemotherapy and radiation therapy. The vaccine is called the Wilms Tumor-1 (WT-1) vaccine. WT-1 is a protein in cancer cells that regulates gene expression and causes cell growth. Mesothelioma tumors generally have high levels of WT-1.
Patients in this study will be randomly assigned to one of two treatment groups. One group will receive non-specific immunotherapy with medications called montanide and GM-CSF. The other group will receive more specific immunotherapy with the WT-1 vaccine plus montanide and GM-CSF.
Both montanide and GM-CSF are commonly given with vaccines because they boost the immune response. Some researchers believe that this general increase in the immune system may have some effect in treating cancer.