Lymphoma Clinical Trials & Research

Our mission has always been a singular one: to care for and cure people with cancer. As part of this goal, we’ve worked for decades to find new treatments, and many of our innovations and approaches have set the standard for care. We won’t give up until we conquer cancer.

In fact, we’re currently studying new approaches to treating lymphoma, and we come closer to finding exciting solutions every day. One of the most important goals we have is to develop new and improved treatments for people with lymphoma who are not helped by standard treatments.

Our doctors are leading a large number of clinical trials to test new drugs and drug combinations. We’re on the hunt for genetic factors linked to lymphoma development and other strategies for improving treatment. These research studies are based on our growing understanding of how lymphoma is different from other cancers, and the research is increasingly “translational,” meaning that discoveries made in the lab are taken directly to our patients.

In other words, choosing MSK may give you access to new treatment options before they’re widely available elsewhere. We have extensive experience in matching patients with the right clinical trials that will benefit them the most.

We do research in:

  • New chemotherap​y approaches
    Our physicians are investigating the effectiveness of various combinations of chemotherapeutic agents and other drugs for non-Hodgkin lymphoma.
  • Pathway-directed (biologic) therapies
    Our investigators are testing drugs that are designed to interrupt or restrain the molecular processes that tumor cells require to grow and spread.
  • Immune strategies
    We’re testing investigational drugs aimed at encouraging the body’s immune system to identify and react against cancer cells.
  • Tumor-directed therapies (radiolabeled antibodies)
    Our researchers are investigating the effectiveness of antibodies (proteins that specifically target cancer cells and carry radioactive molecules) that can potentially kill cancer cells with radiation while minimizing exposure to the rest of the body.

Untreated (Newly Diagnosed)

A Phase IB Study of GDC-0199 (ABT-199 or Venetoclax) with R-CHOP or G-CHOP in Patients with B-Cell Non-Hodgkin Lymphoma
[Protocol 14-130]

Prior Treatment (Relapsed/Refractory)

A Phase II Study of IPI-145 in Patients with Persistent Slow-Growing Non-Hodgkin Lymphoma
Philip C. Caron
[Protocol 15-003]

A Phase IB/IIA Study of Carfilzomib, Romidepsin, and Lenalidomide in Patients with Recurrent or Persistent Lymphoma
Steven M. Horwitz
[Protocol 14-179]

A Phase IB Study of MPDL3280A plus Obinutuzumab in Patients with Recurrent or Persistent Lymphoma
M. Lia Palomba
[Protocol 14-220]

A Phase II Study of Mocetinostat in Patients with Diffuse Large B-cell Lymphoma or Follicular Lymphoma with Certain Mutations
[Protocol 14-106]

A Phase I Study of PRT062070 in Patients with Persistent or Recurrent Chronic Lymphocytic Leukemia, Small Cell Lymphocytic Leukemia, or B-Cell Non-Hodgkin Lymphoma
Paul A. Hamlin
[Protocol 14-023]

A Phase I Study of CPI-0610 in Patients with Progressive Lymphoma
Anas Younes
[Protocol 13-259]

A Phase IB Study of MK-3475 in Patients with Myelodysplastic Syndromes and Lymphoma
Craig H. Moskowitz
[Protocol 13-220]

A Phase Ib Study of Urelumab Given with Rituximab in Patients with Recurrent or Persistent Non-Hodgkin Lymphoma or Chronic Lymphocytic Leukemia
[Protocol 13-252]

A Phase IB Study of GDC-0199 (ABT-199 or Venetoclax) with R-CHOP or G-CHOP in Patients with B-Cell Non-Hodgkin Lymphoma
[Protocol 14-130]

A Phase I Study of IMGN529 in Patients with Recurrent or Persistent Non-Hodgkin Lymphoma
M. Lia Palomba
[Protocol 13-073]

A Phase I Study of SGN-CD19A in Patients with Relapsed or Refractory Non-Hodgkin Lymphoma
Craig H. Moskowitz
[Protocol 12-282]

A Phase I Study of PU-H71 in Patients with Advanced Cancer
John F. Gerecitano
[Protocol 11-041]

Untreated (Newly Diagnosed)

A Phase III Study of Ibrutinib (PCI-32765) plus R-CHOP Chemotherapy in Patients Newly Diagnosed with Diffuse Large B-Cell Lymphoma (DLBCL)
Anas Younes
[Protocol 13-146]

A Phase II Study of Dose-Adjusted EPOCH Chemotherapy with or without Rituximab in Patients with Untreated Burkitt Lymphoma, Diffuse Large B-Cell Lymphoma, or Plasmablastic Lymphoma
Ariela Noy
[Protocol 13-022]

A Phase IB Study of GDC-0199 (ABT-199 or Venetoclax) with R-CHOP or G-CHOP in Patients with B-Cell Non-Hodgkin Lymphoma
[Protocol 14-130]

Prior Treatment (Relapsed/Refractory)

A Phase IB/IIA Study of Carfilzomib, Romidepsin, and Lenalidomide in Patients with Recurrent or Persistent Lymphoma
Steven M. Horwitz
[Protocol 14-179]

A Phase IB Study of MPDL3280A plus Obinutuzumab in Patients with Recurrent or Persistent Lymphoma
M. Lia Palomba
[Protocol 14-220]

A Phase II Study of Mocetinostat in Patients with Diffuse Large B-cell Lymphoma or Follicular Lymphoma with Certain Mutations
[Protocol 14-106]

A Phase I Study of PRT062070 in Patients with Persistent or Recurrent Chronic Lymphocytic Leukemia, Small Cell Lymphocytic Leukemia, or B-Cell Non-Hodgkin Lymphoma
Paul A. Hamlin
[Protocol 14-023]

A Phase I Study of CPI-0610 in Patients with Progressive Lymphoma
Anas Younes
[Protocol 13-259]

A Phase IB Study of MK-3475 in Patients with Myelodysplastic Syndromes and Lymphoma
Craig H. Moskowitz
[Protocol 13-220]

A Phase Ib Study of Urelumab Given with Rituximab in Patients with Recurrent or Persistent Non-Hodgkin Lymphoma or Chronic Lymphocytic Leukemia
[Protocol 13-252]

A Phase I Study of CUDC-907 in Patients with Relapsed or Refractory Lymphoma or Multiple Myeloma
Anas Younes
[Protocol 13-045]

A Phase I Study of High-Dose Therapy and Autologous Stem Cell Transplantation Followed by Modified T Cells for Aggressive B-Cell Non-Hodgkin Lymphoma
Craig S. Sauter
[Protocol 12-117]

A Phase I Study of IMGN529 in Patients with Recurrent or Persistent Non-Hodgkin Lymphoma
M. Lia Palomba
[Protocol 13-073]

A Phase I Study of SGN-CD19A in Patients with Relapsed or Refractory Non-Hodgkin Lymphoma
Craig H. Moskowitz
[Protocol 12-282]

A Phase IB Study of GDC-0199 (ABT-199 or Venetoclax) with R-CHOP or G-CHOP in Patients with B-Cell Non-Hodgkin Lymphoma
[Protocol 14-130]

A Phase I Study of Ibrutinib plus Rituximab, Ifosfamide, Carboplatin, and Etoposide (R-ICE) in Patients with Recurrent or Persistent Diffuse Large B-Cell Lymphoma
Craig S. Sauter
[Protocol 14-145]

A Phase I Study of PU-H71 in Patients with Advanced Cancer
John F. Gerecitano
[Protocol 11-041]

A Phase I Study of Ibrutinib in Patients with Recurrent or Persistent T-Cell Lymphoma
Anita Kumar
[Protocol 14-227]

A Phase IB Study of MPDL3280A plus Obinutuzumab in Patients with Recurrent or Persistent Lymphoma
M. Lia Palomba
[Protocol 14-220]

A Phase I Study of MT-3724 for the Treatment of Relapsed B-cell Non-Hodgkin Lymphoma
Paul A. Hamlin
[Protocol 14-265]

A Phase I/II Study of IMO-8400 in Patients with Persistent or Recurrent Waldenstrom's Macroglobulinemia
M. Lia Palomba
[Protocol 14-078]

A Phase I Study of PRT062070 in Patients with Persistent or Recurrent Chronic Lymphocytic Leukemia, Small Cell Lymphocytic Leukemia, or B-Cell Non-Hodgkin Lymphoma
Paul A. Hamlin
[Protocol 14-023]

A Phase I Study of CPI-0610 in Patients with Progressive Lymphoma
Anas Younes
[Protocol 13-259]

A Phase Ib Study of Urelumab Given with Rituximab in Patients with Recurrent or Persistent Non-Hodgkin Lymphoma or Chronic Lymphocytic Leukemia
[Protocol 13-252]

A Phase I Study of High-Dose Therapy and Autologous Stem Cell Transplantation Followed by Modified T Cells for Aggressive B-Cell Non-Hodgkin Lymphoma
Craig S. Sauter
[Protocol 12-117]

A Phase I Study of CUDC-907 in Patients with Relapsed or Refractory Lymphoma or Multiple Myeloma
Anas Younes
[Protocol 13-045]

A Phase I Study of IMGN529 in Patients with Recurrent or Persistent Non-Hodgkin Lymphoma
M. Lia Palomba
[Protocol 13-073]

A Phase I Study of PU-H71 in Patients with Advanced Cancer
John F. Gerecitano
[Protocol 11-041]

A Phase I Study of Ibrutinib plus Rituximab, Ifosfamide, Carboplatin, and Etoposide (R-ICE) in Patients with Recurrent or Persistent Diffuse Large B-Cell Lymphoma
Craig S. Sauter
[Protocol 14-145]

A Phase IB Study of GDC-0199 (ABT-199 or Venetoclax) with R-CHOP or G-CHOP in Patients with B-Cell Non-Hodgkin Lymphoma
[Protocol 14-130]