Clinical Updates & Insights

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Our clinical updates provide you with timely information about Memorial Sloan Kettering’s new treatment approaches, key clinical trials, and innovations in detecting and treating many cancers.

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218 Clinical Updates found

Clinical Update

Neoadjuvant Chemotherapy May Affect Young Women’s Decisions to Pursue Fertility Preservation Counseling

Young women with breast cancer who receive neoadjuvant chemotherapy are more likely to decline referral to reproductive endocrinology and infertility specialists than women who receive adjuvant chemotherapy.

  • Tuesday, September 8, 2020

Clinical Update

Persistent Radiation-Induced Alopecia Has Distinctive Features and May Benefit from Treatment

Persistent radiation-induced alopecia in patients with primary central nervous system tumors or head and neck sarcomas is dose-dependent and has distinctive clinical and trichoscopic features, but can benefit from treatment.

  • Tuesday, September 8, 2020

Clinical Update

Select Patients with Thyroid Cancer May Not Require Prophylactic Central Compartment Neck Dissection

Select patients with papillary thyroid carcinoma with clinically involved lateral neck nodes may not require prophylactic central compartment neck dissection, enhancing quality of life.

  • Monday, August 17, 2020

Clinical Update

A Single Surviving Myeloma Cell Can Seed Accelerated Relapse

A single surviving myeloma cell can seed accelerated relapse, and more than 20 percent of nonsynonymous mutations at relapse may be induced by exposure to chemotherapy such as platinum and high-dose melphalan after autologous stem cell transplant.

  • Friday, August 14, 2020

Clinical Update

Review: Our Experience with Convection Enhanced Delivery for Diffuse Intrinsic Pontine Glioma

Convection enhanced delivery, an innovative technique that directly infuses a therapeutic agent into a brain tumor through a cannula, bypassing the blood-brain barrier, is safe and feasible for treating diffuse intrinsic pontine glioma in children.

  • Friday, August 14, 2020

Clinical Update

Two New Clinical Trials Increase Treatment Options for Mantle Cell Lymphoma Patients

Two important clinical trials to increase treatment options for mantle cell lymphoma patients are currently recruiting patients.

  • Friday, August 14, 2020

Clinical Update

What We’ve Learned by Sequencing 60,000 Samples with MSK-IMPACT

At Memorial Sloan Kettering Cancer Center, we have now analyzed more than 50,000 samples in our prospective cohort with MSK-IMPACT™.

  • Thursday, August 13, 2020

Clinical Update

Alterations in Driver Genes Predict Survival in Patients with Resected Pancreatic Ductal Adenocarcinoma

In patients with resected pancreatic ductal adenocarcinoma, alterations in KRAS and TP53 were associated with worse outcomes, whereas alterations in homologous recombination deficiency genes were associated with favorable prognoses.

  • Thursday, July 16, 2020

Clinical Update

Severity of COVID-19 in Patients with Lung Cancer: Not Driven by Cancer or Cancer Treatments

Our study, published recently in the Annals of Oncology, suggests that the greatest determinants of COVID-19 severity were patient features and comorbidities, such as a history of heavy smoking and chronic obstructive pulmonary disease (COPD).

  • Thursday, July 16, 2020

Clinical Update

CAR T Update Part 1: Learning and Opportunities in Hematologic Cancers

In our paper, published recently in the journal Expert Review of Hematology, we review the main challenges with current CD19-targeted CAR, obstacles to adopting CAR T cell therapy in solid tumors, and various strategies scientists are pursuing to overcome these issues.

  • Thursday, June 11, 2020