Improvements in staging, advances in surgical technology, and enhanced appreciation for the heterogeneity of gastric cancer has led to significant progress in treating the disease. We have one of the nation’s highest surgical volumes for this cancer, performing approximately 100 gastrectomies annually (open and laparoscopic). Evidence indicates that our minimally invasive approach yields shorter hospital stays, decreased need for postoperative pain relief, and fewer postsurgical complications. Rates of recurrence-free survival at 36-month follow-up are similar to open surgery. We are one of the few NCI-designated cancer centers with a specific program in upper gastrointestinal tract cancers.