Ketoconazole (Topical

This information from Lexicomp® explains what you need to know about this medication, including what it’s used for, how to take it, its side effects, and when to call your healthcare provider.

Brand Names: US

Extina [DSC]; Ketodan; Nizoral A-D [OTC] [DSC]; Nizoral [DSC]; Xolegel [DSC]

Brand Names: Canada

Ketoderm

What is this drug used for?

  • It is used to treat fungal infections of the skin.
  • It is used to control seborrheic dermatitis.
  • It is used to treat dandruff.

What do I need to tell my doctor BEFORE I take this drug?

  • If you are allergic to this drug; any part of this drug; or any other drugs, foods, or substances. Tell your doctor about the allergy and what signs you had.

This drug may interact with other drugs or health problems.

Tell your doctor and pharmacist about all of your drugs (prescription or OTC, natural products, vitamins) and health problems. You must check to make sure that it is safe for you to take this drug with all of your drugs and health problems. Do not start, stop, or change the dose of any drug without checking with your doctor.

What are some things I need to know or do while I take this drug?

All products:

  • Tell all of your health care providers that you take this drug. This includes your doctors, nurses, pharmacists, and dentists.
  • If you are allergic to sulfites, talk with your doctor. Some products have sulfites.
  • Talk with your doctor before you use other drugs or products on your skin.
  • This drug may cause harm if swallowed. If this drug is swallowed, call a doctor or poison control center right away.
  • Tell your doctor if you are pregnant, plan on getting pregnant, or are breast-feeding. You will need to talk about the benefits and risks to you and the baby.

Cream, foam, and gel:

  • If you are breast-feeding, do not put this drug right on the nipple or the area right around it.

Foam and gel:

  • This drug may catch on fire. Do not use near an open flame or while smoking.

What are some side effects that I need to call my doctor about right away?

WARNING/CAUTION: Even though it may be rare, some people may have very bad and sometimes deadly side effects when taking a drug. Tell your doctor or get medical help right away if you have any of the following signs or symptoms that may be related to a very bad side effect:

All products:

  • Signs of an allergic reaction, like rash; hives; itching; red, swollen, blistered, or peeling skin with or without fever; wheezing; tightness in the chest or throat; trouble breathing, swallowing, or talking; unusual hoarseness; or swelling of the mouth, face, lips, tongue, or throat.

Foam:

  • Rash if the treated area is in the sun.

What are some other side effects of this drug?

All drugs may cause side effects. However, many people have no side effects or only have minor side effects. Call your doctor or get medical help if any of these side effects or any other side effects bother you or do not go away:

All products:

  • Burning.
  • Irritation where this drug was used.

Shampoo:

  • Takes curl out of hair.
  • Hair loss.
  • Change in color of hair.
  • Change in hair texture.
  • Itching.
  • Dry skin.

These are not all of the side effects that may occur. If you have questions about side effects, call your doctor. Call your doctor for medical advice about side effects.

You may report side effects to your national health agency.

You may report side effects to the FDA at 1-800-332-1088. You may also report side effects at https://www.fda.gov/medwatch.

How is this drug best taken?

Use this drug as ordered by your doctor. Read all information given to you. Follow all instructions closely.

Cream, foam, and gel:

  • Do not take this drug by mouth. Use on your skin only. Keep out of your mouth, nose, and eyes (may burn).
  • Do not put in the vagina.
  • Use as you have been told, even if your signs get better.
  • Wash your hands before and after use. If your hand is the treated area, do not wash your hand after use.
  • Clean affected part before use. Make sure to dry well.
  • Put a thin layer on the affected skin and rub in gently.
  • Do not use coverings (bandages, dressings) unless told to do so by the doctor.
  • If your skin is broken or swollen, talk with your doctor before using this drug. Some drugs are not for use on broken or swollen skin.

Foam:

  • Hold upright to use. Do not turn upside down.
  • Put the foam into the cap of the can or onto another cool surface. Do not place foam right in your hands because it will melt. Pick up a little foam with your fingertips and rub into the affected area until you cannot see the foam. If there is hair on the affected area, part the hair to put the foam on the skin instead of the hair.

Gel:

  • Do not bathe, shower, or swim for 3 hours after putting on.

Shampoo:

  • Do not take this drug by mouth. Use on your scalp and hair only. Keep out of your mouth, nose, ears, and eyes (may burn).
  • Use as you have been told, even if your signs get better.
  • Wet hair and scalp.
  • Put on enough shampoo to make a lather.
  • Lather well and leave on as you have been told.
  • Rinse well.
  • If your skin is broken or swollen, talk with your doctor before using this drug. Some drugs are not for use on broken or swollen skin.

What do I do if I miss a dose?

  • Use a missed dose as soon as you think about it.
  • If it is close to the time for your next dose, skip the missed dose and go back to your normal time.
  • Do not use 2 doses at the same time or extra doses.

How do I store and/or throw out this drug?

All products:

  • Store at room temperature. Do not refrigerate or freeze.
  • Store in a dry place. Do not store in a bathroom.
  • Keep all drugs in a safe place. Keep all drugs out of the reach of children and pets.
  • Throw away unused or expired drugs. Do not flush down a toilet or pour down a drain unless you are told to do so. Check with your pharmacist if you have questions about the best way to throw out drugs. There may be drug take-back programs in your area.

Foam and gel:

  • Protect from heat or open flame.

Foam:

  • Protect from heat and sunlight. Do not puncture or burn even if it seems empty.

Shampoo:

  • Protect from light.

General drug facts

  • If your symptoms or health problems do not get better or if they become worse, call your doctor.
  • Do not share your drugs with others and do not take anyone else’s drugs.
  • Some drugs may have another patient information leaflet. If you have any questions about this drug, please talk with your doctor, nurse, pharmacist, or other health care provider.
  • Some drugs may have another patient information leaflet. Check with your pharmacist. If you have any questions about this drug, please talk with your doctor, nurse, pharmacist, or other health care provider.
  • If you think there has been an overdose, call your poison control center or get medical care right away. Be ready to tell or show what was taken, how much, and when it happened.

Consumer Information Use and Disclaimer

This generalized information is a limited summary of diagnosis, treatment, and/or medication information. It is not meant to be comprehensive and should be used as a tool to help the user understand and/or assess potential diagnostic and treatment options. It does NOT include all information about conditions, treatments, medications, side effects, or risks that may apply to a specific patient. It is not intended to be medical advice or a substitute for the medical advice, diagnosis, or treatment of a health care provider based on the health care provider’s examination and assessment of a patient’s specific and unique circumstances. Patients must speak with a health care provider for complete information about their health, medical questions, and treatment options, including any risks or benefits regarding use of medications. This information does not endorse any treatments or medications as safe, effective, or approved for treating a specific patient. UpToDate, Inc. and its affiliates disclaim any warranty or liability relating to this information or the use thereof. The use of this information is governed by the Terms of Use, available at https://www.wolterskluwer.com/en/know/clinical-effectiveness-terms.

Last Reviewed Date

2024-03-29

Copyright

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Last Updated

Monday, December 12, 2022